2024
Genomic surveillance of malaria parasites in an indigenous community in the Peruvian Amazon
Cabrera-Sosa L, Nolasco O, Kattenberg J, Fernandez-Miñope C, Valdivia H, Barazorda K, Arévalo de los Rios S, Rodriguez-Ferrucci H, Vinetz J, Rosanas-Urgell A, Van geertruyden J, Gamboa D, Delgado-Ratto C. Genomic surveillance of malaria parasites in an indigenous community in the Peruvian Amazon. Scientific Reports 2024, 14: 16291. PMID: 39009685, PMCID: PMC11250820, DOI: 10.1038/s41598-024-66925-x.Peer-Reviewed Original ResearchConceptsPassive case detectionPf parasitesPersistent malaria transmissionPfhrp2/3 gene deletionsDeep sequencing assaySulfadoxine-pyrimethamineMalaria casesMalaria eliminationPlasmodium vivaxMalaria parasitesMalaria transmissionP. falciparumResistance mutationsImported infectionsMalariaPopulation genetic indicesSequencing assayCase detectionGene deletionPV populationResistance markersGenetic diversityPeruvian AmazonGenomic surveillanceGenetic indicesEffect of spatiotemporal variables on abundance, biting activity and parity of Nyssorhynchus darlingi (Diptera: Culicidae) in peri-Iquitos, Peru
Bickersmith S, Saavedra M, Prussing C, Lange R, Morales J, Alava F, Vinetz J, Gamboa D, Moreno M, Conn J. Effect of spatiotemporal variables on abundance, biting activity and parity of Nyssorhynchus darlingi (Diptera: Culicidae) in peri-Iquitos, Peru. Malaria Journal 2024, 23: 112. PMID: 38641572, PMCID: PMC11031940, DOI: 10.1186/s12936-024-04940-z.Peer-Reviewed Original ResearchConceptsMalaria transmissionBreeding site availabilityPresence of Plasmodium vivaxDry seasonBiting behaviorRisk of malaria transmissionMalaria-endemic regionsHuman malaria casesPlasmodium falciparum sporozoitesRainy seasonCommunity typesNyssorhynchus darlingiRates of parityReal-time PCRAmazonian PeruP. vivaxMalaria casesPlasmodium vivaxHuman landing catchesP. falciparumEffect of seasonMosquito behaviorConclusionsThese dataDaily survivalDarlingi
2021
Integrating Parasitological and Entomological Observations to Understand Malaria Transmission in Riverine Villages in the Peruvian Amazon
Rosas-Aguirre A, Moreno M, Moreno-Gutierrez D, Llanos-Cuentas A, Saavedra M, Contreras-Mancilla J, Barboza J, Alava F, Aguirre K, Carrasco G, Prussing C, Vinetz J, Conn JE, Speybroeck N, Gamboa D. Integrating Parasitological and Entomological Observations to Understand Malaria Transmission in Riverine Villages in the Peruvian Amazon. The Journal Of Infectious Diseases 2021, 223: s99-s110. PMID: 33906225, PMCID: PMC8079135, DOI: 10.1093/infdis/jiaa496.Peer-Reviewed Original ResearchConceptsMalaria prevalenceMalaria transmissionRiverine villagesMalaria risk factorsMalaria transmission dynamicsSubmicroscopic infectionsLocal epidemiologyPolymerase chain reactionIncidence rateRisk factorsHigh prevalenceMalaria casesTreat interventionMalaria strategyPlasmodium vivaxPrevalenceChain reactionTransmission dynamicsAdult AnophelesHigh heterogeneity
2016
Epidemiology of Plasmodium vivax Malaria in Peru
Rosas-Aguirre A, Gamboa D, Manrique P, Conn JE, Moreno M, Lescano AG, Sanchez JF, Rodriguez H, Silva H, Llanos-Cuentas A, Vinetz JM. Epidemiology of Plasmodium vivax Malaria in Peru. American Journal Of Tropical Medicine And Hygiene 2016, 95: 133-144. PMID: 27799639, PMCID: PMC5201219, DOI: 10.4269/ajtmh.16-0268.Peer-Reviewed Original ResearchConceptsMalaria transmissionP. vivaxMalaria controlPlasmodium falciparum malaria casesMicroscopy-confirmed casesP. vivax malaria transmissionFalciparum malaria casesPlasmodium vivax malariaVivax malaria transmissionPublic health problemGlucose-6-phosphate dehydrogenase deficiencyFuture malaria controlImplementation of surveillanceCombination therapyVivax malariaClinical trialsMalaria casesPlasmodium vivaxElimination effortsHealth problemsP. falciparumMosquito transmissionDehydrogenase deficiencyVivaxOngoing surveillance activities