2005
On the Effect of Prestin on the Electrical Breakdown of Cell Membranes
Navarrete EG, Santos-Sacchi J. On the Effect of Prestin on the Electrical Breakdown of Cell Membranes. Biophysical Journal 2005, 90: 967-974. PMID: 16299081, PMCID: PMC1367121, DOI: 10.1529/biophysj.105.064105.Peer-Reviewed Original ResearchConceptsTSA cellsWhole cell levelVoltage-dependent activityGuinea pig OHCsOuter hair cell motor proteinMotor proteinsPM domainsMaximum transmembrane potentialPrestin activityMembrane susceptibilityTransmembrane potentialCell membranePrestinTsA201 cellsBiophysical influencesMembrane stiffnessElectroporationCellsBasal portionSignificant resistanceMembrane capacitanceProteinElectromotilityAuditory sensitivitySusceptibility
2001
Furosemide alters nonlinear capacitance in isolated outer hair cells
Santos-Sacchi J, Wu M, Kakehata S. Furosemide alters nonlinear capacitance in isolated outer hair cells. Hearing Research 2001, 159: 69-73. PMID: 11520635, DOI: 10.1016/s0378-5955(01)00321-5.Peer-Reviewed Original ResearchConceptsOuter hair cellsWhole-cell patch-clamp techniqueHair cellsNormal cochlear functionIsolated outer hair cellsPatch-clamp techniqueOrgan of CortiLoop diureticsSensory dysfunctionHearing resultsCochlear functionEndolymphatic potentialFurosemideDirect effectHill coefficientPositive levelCellsDiureticsDysfunctionPresent results
1998
Effects of Lipophilic Ions on Outer Hair Cell Membrane Capacitance and Motility
Wu M, Santos-Sacchi J. Effects of Lipophilic Ions on Outer Hair Cell Membrane Capacitance and Motility. The Journal Of Membrane Biology 1998, 166: 111-118. PMID: 9841736, DOI: 10.1007/s002329900453.Peer-Reviewed Original ResearchTemperature dependence of outer hair cell nonlinear capacitance
Santos-Sacchi J, Huang G. Temperature dependence of outer hair cell nonlinear capacitance. Hearing Research 1998, 116: 99-106. PMID: 9508032, DOI: 10.1016/s0378-5955(97)00204-9.Peer-Reviewed Original Research
1994
Motility voltage sensor of the outer hair cell resides within the lateral plasma membrane.
Huang G, Santos-Sacchi J. Motility voltage sensor of the outer hair cell resides within the lateral plasma membrane. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 12268-12272. PMID: 7991617, PMCID: PMC45418, DOI: 10.1073/pnas.91.25.12268.Peer-Reviewed Original Research