2024
Cellular Mechanisms Underlying the Pathogenetic Role of the Primary Cilium in Pulmonary Arterial Hypertension
Melnikov A, Solymosi P, Pennitz P, Schupp J, Nouailles G, Perret P, Gallo K, Hegemann N, Nambiar Veetil N, Klepetko W, Sinn K, Erfinanda L, Simmons S, Kucherenko M, Knosalla C, Preissner R, Kwapiszewska G, Witzenrath M, Kuebler W. Cellular Mechanisms Underlying the Pathogenetic Role of the Primary Cilium in Pulmonary Arterial Hypertension. 2024, a6790-a6790. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6790.Peer-Reviewed Original ResearchPulmonary arterial hypertensionArterial hypertensionPathogenetic roleCellular mechanismsPrimary ciliaHypertension
2023
Effects of sotatercept on lung diffusion capacity and blood gases in patients with pulmonary arterial hypertension
Olsson K, Fuge J, Park D, Kamp J, Brod T, Harrigfeld B, Schupp J, Hoeper M. Effects of sotatercept on lung diffusion capacity and blood gases in patients with pulmonary arterial hypertension. European Respiratory Journal 2023, 62: 2301070. PMID: 37474157, DOI: 10.1183/13993003.01070-2023.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionLung diffusion capacityArterial hypertensionDiffusion capacityRight heart functionRight ventricular afterloadSmall pulmonary vesselsVentricular afterloadBlood gasesPulmonary vesselsHeart functionRare diseaseHypertensionPatientsSotaterceptProgressive increaseSymptomsVariable alterationsDisease symptomsGas exchangeAfterloadDiseaseSeverity
2022
A Morphomolecular Approach to Alveolar Capillary Dysplasia
Kamp J, Neubert L, Ackermann M, Stark H, Plucinski E, Shah H, Janciauskiene S, Bergmann A, Schmidt G, Welte T, Haverich A, Werlein C, Braubach P, Laenger F, Schwerk N, Olsson K, Fuge J, Park D, Schupp J, Hoeper M, Kuehnel M, Jonigk D. A Morphomolecular Approach to Alveolar Capillary Dysplasia. American Journal Of Pathology 2022, 192: 1110-1121. PMID: 35649494, DOI: 10.1016/j.ajpath.2022.05.004.Peer-Reviewed Original ResearchConceptsAlveolar capillary dysplasiaHigh prevalencePersistent pulmonary arterial hypertensionPulmonary arterial hypertension groupC motif chemokine receptor 4CXCR4 ligand CXCL12Pulmonary arterial hypertensionEndothelial tyrosine kinase receptorHypoxia-inducible factor-1αChemokine receptor 4Anti-angiogenic agentsIntussusceptive angiogenesisArterial hypertensionHypertension groupTyrosine kinase receptorsFatal outcomeHealthy controlsReceptor 4Ligand CXCL12Vascular remodelingMicrovascular corrosion castsACD groupMicrovascular morphologyFactor-1αExome sequencing