2002
Spaceflight Induces Changes in the Synaptic Circuitry of the Postnatal Developing Neocortex
DeFelipe J, Arellano J, Merchán-Pérez A, González-Albo M, Walton K, Llinás R. Spaceflight Induces Changes in the Synaptic Circuitry of the Postnatal Developing Neocortex. Cerebral Cortex 2002, 12: 883-891. PMID: 12122037, DOI: 10.1093/cercor/12.8.883.Peer-Reviewed Original ResearchConceptsLayers II/IIISynaptic circuitrySynaptic densityFlight animalsLaminar-specific mannerLower synaptic densityDensity of synapsesDays of spaceflightAsymmetrical synapsesCortical synapsesLayer IVCortical synaptogenesisLong-term spaceflightControl animalsDeveloping NeocortexAdult patternCortical organizationNeocortical circuitrySynapsesGround control animalsMonth periodSignificant differencesFuture long-term spaceflightsAnimalsNeocortical representationsSynaptically Released Acetylcholine Evokes Ca2+Elevations in Astrocytes in Hippocampal Slices
Araque A, Martín E, Perea G, Arellano J, Buño W. Synaptically Released Acetylcholine Evokes Ca2+Elevations in Astrocytes in Hippocampal Slices. Journal Of Neuroscience 2002, 22: 2443-2450. PMID: 11923408, PMCID: PMC6758296, DOI: 10.1523/jneurosci.22-07-02443.2002.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsAstrocytesCalciumCholinergic FibersDiagonal Band of BrocaElectric StimulationGlutamic AcidHippocampusIn Vitro TechniquesIntracellular FluidNeurons, AfferentNeurotransmitter AgentsPatch-Clamp TechniquesRatsRats, WistarReceptors, GlutamateReceptors, MuscarinicSeptum of BrainSignal TransductionSynapsesConceptsAstrocytic responseIntracellular Ca2Stratum oriens/alveusHippocampal stratum oriensOriens/alveusMuscarinic cholinergic receptorsGlutamate receptor antagonistsGlutamate transporter activityWhole-cell membrane currentsDifferent brain areasLevels of astrocytesCholinergic receptorsHippocampal astrocytesMuscarinic receptorsCholinergic activityReceptor antagonistStratum oriensAcetylcholine actsCholinergic afferentsAxonal inputsHippocampal slicesDiagonal bandGlial cellsTransporter antagonistsBrain slices
2001
Microtubule-associated protein 2 phosphorylation is decreased in the human epileptic temporal lobe cortex
Sánchez C, Arellano J, Rodríguez-Sánchez P, Avila J, DeFelipe J, Díez-Guerra F. Microtubule-associated protein 2 phosphorylation is decreased in the human epileptic temporal lobe cortex. Neuroscience 2001, 107: 25-33. PMID: 11744243, DOI: 10.1016/s0306-4522(01)00338-4.Peer-Reviewed Original ResearchConceptsEpileptic patientsMAP2 phosphorylationEpileptiform activityKynurenic acidTemporal lobe epileptic patientsNeuronal cytoskeletonSeizure-like activityTemporal lobe cortexNeuronal cell deathRat hippocampal neuronsProtein 2 phosphorylationNeuronal damageSeizure activityGlutamate receptorsHippocampal neuronsNeuronal activityBiopsy samplesSynaptic plasticityPatientsElectrocorticogram activityNeuronal processesExperimental modelAbnormal patternsImmunocytochemical analysisPhosphorylated epitopes
1999
Variation in the spatial relationship between parvalbumin immunoreactive interneurones and pyramidal neurones in rat somatosensory cortex
Elston G, DeFelipe J, Arellano J, del Carmen Gonzilez-Albo M, Rosa M. Variation in the spatial relationship between parvalbumin immunoreactive interneurones and pyramidal neurones in rat somatosensory cortex. Neuroreport 1999, 10: 2975-2979. PMID: 10549808, DOI: 10.1097/00001756-199909290-00019.Peer-Reviewed Original ResearchConceptsPyramidal neuronesLayer VLucifer YellowSomatosensory cortexLayer IIICell bodiesRat primary somatosensory cortexTangential cortical slicesPrimary somatosensory cortexImmunoreactive cell bodiesBasal dendritic fieldsRat somatosensory cortexCombination of antibodiesReceptive field propertiesDendritic territoriesCortical slicesInhibitory modulationDendritic fieldsCortical neuronesIntracellular injectionNeuronesCortexConfocal microscopyFunctional implicationsSlices