2022
Neuroanatomical and psychological considerations in temporal lobe epilepsy
DeFelipe J, DeFelipe-Oroquieta J, Furcila D, Muñoz-Alegre M, Maestú F, Sola R, Blázquez-Llorca L, Armañanzas R, Kastanaskaute A, Alonso-Nanclares L, Rockland K, Arellano J. Neuroanatomical and psychological considerations in temporal lobe epilepsy. Frontiers In Neuroanatomy 2022, 16: 995286. PMID: 36590377, PMCID: PMC9794593, DOI: 10.3389/fnana.2022.995286.Peer-Reviewed Original ResearchTemporal lobe epilepsyBrain samplesLobe epilepsyEpileptic patientsBrain tissuePutative anatomical substratesTypes of patientsAbnormal brain functioningHippocampal sclerosisEpilepsy surgeryTLE patientsEpileptic tissuePsychopathological alterationsFocal epilepsyNormal histologyIndividual variabilityCritical patient informationMedical characteristicsPatientsAnatomical substratePost-surgical performancePsychological alterationsNeuropsychological evaluationEpilepsySubstantial individual variability
2004
CA1 Hippocampal Neuronal Loss in Familial Alzheimer's Disease Presenilin‐1 E280A Mutation Is Related to Epilepsy
Velez‐Pardo C, Arellano J, Cardona‐Gomez P, Del Rio M, Lopera F, De Felipe J. CA1 Hippocampal Neuronal Loss in Familial Alzheimer's Disease Presenilin‐1 E280A Mutation Is Related to Epilepsy. Epilepsia 2004, 45: 751-756. PMID: 15230697, DOI: 10.1111/j.0013-9580.2004.55403.x.Peer-Reviewed Original ResearchConceptsHippocampal neuronal lossNeuronal lossCA1 fieldAlzheimer's diseaseFAD patientsEpileptic seizuresPresenilin-1 E280A mutationMesial temporal lobe structuresAppearance of epilepsyCA1 hippocampal regionNeuronal cell lossSubpopulation of patientsFamilial AD patientsTemporal lobe structuresPresenilin 1 mutationNeuronal depopulationHippocampal sclerosisAD pathologyAD patientsNeurofibrillary tanglesEpilepsy patientsHippocampal regionHippocampal formationPatientsCoronal sections
2002
A Model of Human Cortical Microcircuits for the Study of the Development of Epilepsy
Sánchez-Montañés M, Lago-Fernández L, Castellanos N, Merchán-Pérez Á, Arellano J, DeFelipe J. A Model of Human Cortical Microcircuits for the Study of the Development of Epilepsy. Lecture Notes In Computer Science 2002, 2415: 248-253. DOI: 10.1007/3-540-46084-5_41.Peer-Reviewed Original ResearchDevelopment of epilepsyChandelier cellsDevelopment of seizuresHuman neocortical tissueHuman cortical microcircuitsBrain lesionsInhibitory interneuronsNeocortical tissueCortical circuitryEpileptogenic regionEpileptic patientsStructural abnormalitiesEpilepsyCortical microcircuitsSpecific alterationsCell typesCellsPatientsSeizuresThe neuropathology of temporal lobe epilepsy: primary and secondary changes in the cortical circuits and epileptogenicity.
DeFelipe Oroquieta J, Arellano J, Alonso L, Muñoz A. The neuropathology of temporal lobe epilepsy: primary and secondary changes in the cortical circuits and epileptogenicity. Revista De Neurologia 2002, 34: 401-8. PMID: 12040509, DOI: 10.33588/rn.3405.2001403.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyPrimary epileptogenic regionEpileptogenic regionEpileptic activitySynaptic reorganizationLobe epilepsySpecific anatomical connectionsMesial sclerosisNeuronal lossPerilesional areaCommon pathologyInitial lesionCortical circuitsHippocampal formationNeuronal circuitsAnatomical connectionsCortical tissueSecondary changesEpilepsySimilar changesLesionsGliosisEpileptogenicitySclerosisPatients
2001
Microtubule-associated protein 2 phosphorylation is decreased in the human epileptic temporal lobe cortex
Sánchez C, Arellano J, Rodríguez-Sánchez P, Avila J, DeFelipe J, Díez-Guerra F. Microtubule-associated protein 2 phosphorylation is decreased in the human epileptic temporal lobe cortex. Neuroscience 2001, 107: 25-33. PMID: 11744243, DOI: 10.1016/s0306-4522(01)00338-4.Peer-Reviewed Original ResearchConceptsEpileptic patientsMAP2 phosphorylationEpileptiform activityKynurenic acidTemporal lobe epileptic patientsNeuronal cytoskeletonSeizure-like activityTemporal lobe cortexNeuronal cell deathRat hippocampal neuronsProtein 2 phosphorylationNeuronal damageSeizure activityGlutamate receptorsHippocampal neuronsNeuronal activityBiopsy samplesSynaptic plasticityPatientsElectrocorticogram activityNeuronal processesExperimental modelAbnormal patternsImmunocytochemical analysisPhosphorylated epitopes