2022
Neuroanatomical and psychological considerations in temporal lobe epilepsy
DeFelipe J, DeFelipe-Oroquieta J, Furcila D, Muñoz-Alegre M, Maestú F, Sola R, Blázquez-Llorca L, Armañanzas R, Kastanaskaute A, Alonso-Nanclares L, Rockland K, Arellano J. Neuroanatomical and psychological considerations in temporal lobe epilepsy. Frontiers In Neuroanatomy 2022, 16: 995286. PMID: 36590377, PMCID: PMC9794593, DOI: 10.3389/fnana.2022.995286.Peer-Reviewed Original ResearchTemporal lobe epilepsyBrain samplesLobe epilepsyEpileptic patientsBrain tissuePutative anatomical substratesTypes of patientsAbnormal brain functioningHippocampal sclerosisEpilepsy surgeryTLE patientsEpileptic tissuePsychopathological alterationsFocal epilepsyNormal histologyIndividual variabilityCritical patient informationMedical characteristicsPatientsAnatomical substratePost-surgical performancePsychological alterationsNeuropsychological evaluationEpilepsySubstantial individual variability
2002
A Model of Human Cortical Microcircuits for the Study of the Development of Epilepsy
Sánchez-Montañés M, Lago-Fernández L, Castellanos N, Merchán-Pérez Á, Arellano J, DeFelipe J. A Model of Human Cortical Microcircuits for the Study of the Development of Epilepsy. Lecture Notes In Computer Science 2002, 2415: 248-253. DOI: 10.1007/3-540-46084-5_41.Peer-Reviewed Original ResearchDevelopment of epilepsyChandelier cellsDevelopment of seizuresHuman neocortical tissueHuman cortical microcircuitsBrain lesionsInhibitory interneuronsNeocortical tissueCortical circuitryEpileptogenic regionEpileptic patientsStructural abnormalitiesEpilepsyCortical microcircuitsSpecific alterationsCell typesCellsPatientsSeizuresThe neuropathology of temporal lobe epilepsy: primary and secondary changes in the cortical circuits and epileptogenicity.
DeFelipe Oroquieta J, Arellano J, Alonso L, Muñoz A. The neuropathology of temporal lobe epilepsy: primary and secondary changes in the cortical circuits and epileptogenicity. Revista De Neurologia 2002, 34: 401-8. PMID: 12040509, DOI: 10.33588/rn.3405.2001403.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyPrimary epileptogenic regionEpileptogenic regionEpileptic activitySynaptic reorganizationLobe epilepsySpecific anatomical connectionsMesial sclerosisNeuronal lossPerilesional areaCommon pathologyInitial lesionCortical circuitsHippocampal formationNeuronal circuitsAnatomical connectionsCortical tissueSecondary changesEpilepsySimilar changesLesionsGliosisEpileptogenicitySclerosisPatients