2003
Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampus
Arellano J, Muñoz A, Ballesteros-Yáñez I, Sola R, DeFelipe J. Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampus. Brain 2003, 127: 45-64. PMID: 14534159, DOI: 10.1093/brain/awh004.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCalbindinsCarrier ProteinsDentate GyrusEpilepsy, Temporal LobeFemaleGABA Plasma Membrane Transport ProteinsHippocampusHumansImmunoenzyme TechniquesInterneuronsMaleMembrane ProteinsMembrane Transport ProteinsMiddle AgedNeural Cell Adhesion Molecule L1Organic Anion TransportersParvalbuminsPresynaptic TerminalsS100 Calcium Binding Protein GSialic AcidsTerminology as TopicConceptsCalbindin D-28kChandelier cellsDentate gyrusProtein parvalbuminHippocampal formationSclerotic hippocampusGABAergic circuitsNeuron lossPyramidal layerCalcium-binding protein parvalbuminBasket formationImpairment of GABANormal hippocampal formationHuman epileptic hippocampusTemporal lobe epilepsyCortical pyramidal cellsAxon initial segmentNeural cell adhesion moleculeGABA transporter 1PV-immunoreactiveHippocampal sclerosisClinical characteristicsEpileptic hippocampusLobe epilepsyDifferent hippocampal fields
2002
A Model of Human Cortical Microcircuits for the Study of the Development of Epilepsy
Sánchez-Montañés M, Lago-Fernández L, Castellanos N, Merchán-Pérez Á, Arellano J, DeFelipe J. A Model of Human Cortical Microcircuits for the Study of the Development of Epilepsy. Lecture Notes In Computer Science 2002, 2415: 248-253. DOI: 10.1007/3-540-46084-5_41.Peer-Reviewed Original ResearchDevelopment of epilepsyChandelier cellsDevelopment of seizuresHuman neocortical tissueHuman cortical microcircuitsBrain lesionsInhibitory interneuronsNeocortical tissueCortical circuitryEpileptogenic regionEpileptic patientsStructural abnormalitiesEpilepsyCortical microcircuitsSpecific alterationsCell typesCellsPatientsSeizures
2001
Pyramidal cell axons show a local specialization for GABA and 5‐HT inputs in monkey and human cerebral cortex
DeFelipe J, Arellano J, Gómez A, Azmitia E, Muñoz A. Pyramidal cell axons show a local specialization for GABA and 5‐HT inputs in monkey and human cerebral cortex. The Journal Of Comparative Neurology 2001, 433: 148-155. PMID: 11283956, DOI: 10.1002/cne.1132.Peer-Reviewed Original ResearchConceptsChandelier cell axon terminalsGamma-aminobutyric acidPyramidal cell axonsCerebral cortexPyramidal cellsAxon terminalsCell axonsHuman cerebral cortexDouble-labeling experimentsPowerful inhibitory mechanismChandelier cellsMonkey neocortexGABAergic interneuronsImmunoreactive fibersSerotonin receptorsSerotonin afferentsAxonal specializationsParacrine mannerLayers IISynaptic connectionsImmunocytochemical methodsProximal portionInhibitory mechanismClose appositionConfocal laser microscopy