Featured Publications
Increasing the resilience of plant immunity to a warming climate
Kim JH, Castroverde CDM, Huang S, Li C, Hilleary R, Seroka A, Sohrabi R, Medina-Yerena D, Huot B, Wang J, Nomura K, Marr SK, Wildermuth MC, Chen T, MacMicking JD, He SY. Increasing the resilience of plant immunity to a warming climate. Nature 2022, 607: 339-344. PMID: 35768511, PMCID: PMC9279160, DOI: 10.1038/s41586-022-04902-y.Peer-Reviewed Original ResearchConceptsSalicylic acidTranscription factorsSA productionPlant immune systemEffector-triggered immunityPlant growth temperatureFamily transcription factorsAspects of plantImmune transcription factorsElevated growth temperaturesPlant immunityArabidopsis thalianaBiosynthetic genesBasal immunityPlant growthSA receptorsCBP60Disease triangleWarming climateImpaired recruitmentGrowth temperatureAnimal lifeExtreme weather conditionsSARD1Climate changeInterferon-induced guanylate-binding proteins: Guardians of host defense in health and disease
Tretina K, Park ES, Maminska A, MacMicking JD. Interferon-induced guanylate-binding proteins: Guardians of host defense in health and disease. Journal Of Experimental Medicine 2019, 216: 482-500. PMID: 30755454, PMCID: PMC6400534, DOI: 10.1084/jem.20182031.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsColitisGTP-Binding ProteinsHost-Parasite InteractionsHost-Pathogen InteractionsHumansInflammasomesInflammationInterferonsVertebratesConceptsGuanylate-binding proteinsNumerous host cell typesHost cell typesImportant human diseasesCritical rheostatBasic biologyMicrobial pathogensHost defense activitiesHuman diseasesSimilar functionsCell typesHomeostatic settingsGTPasesInnate immunityDefense activitiesHost defenseInflammatory syndromeNeoplastic diseaseClinical approachTissue damageBacterial infectionsCentral orchestratorDiseaseIFNRheostatInterferon-induced guanylate-binding proteins in inflammasome activation and host defense
Kim BH, Chee JD, Bradfield CJ, Park ES, Kumar P, MacMicking JD. Interferon-induced guanylate-binding proteins in inflammasome activation and host defense. Nature Immunology 2016, 17: 481-489. PMID: 27092805, PMCID: PMC4961213, DOI: 10.1038/ni.3440.Peer-Reviewed Original ResearchCellular Self-Defense: How Cell-Autonomous Immunity Protects Against Pathogens
Randow F, MacMicking JD, James LC. Cellular Self-Defense: How Cell-Autonomous Immunity Protects Against Pathogens. Science 2013, 340: 701-706. PMID: 23661752, PMCID: PMC3863583, DOI: 10.1126/science.1233028.Peer-Reviewed Original ResearchMeSH KeywordsCell LineageHost-Pathogen InteractionsHumansImmunity, CellularInfectionsRibonucleoproteinsToxoplasma
2019
Cell-autonomous immunity by IFN-induced GBPs in animals and plants
Huang S, Meng Q, Maminska A, MacMicking JD. Cell-autonomous immunity by IFN-induced GBPs in animals and plants. Current Opinion In Immunology 2019, 60: 71-80. PMID: 31176142, PMCID: PMC6800610, DOI: 10.1016/j.coi.2019.04.017.Peer-Reviewed Original ResearchConceptsGuanylate binding proteinsHost cell interiorCell-autonomous immunitySensory hubMammalian cytosolAnimal kingdomDownstream effectorsDirect bactericidal activityHost cellsBinding proteinCell interiorBacterial pathogensPlantsRecruitment platformDefensive repertoireArabidopsisOrthologuesGTPasesPhytopathogensBacterial colonizationMicrobesCytosolEffectorsProteinColonization
2017
Bacteria disarm host-defence proteins
MacMicking JD. Bacteria disarm host-defence proteins. Nature 2017, 551: 303-304. PMID: 29072295, DOI: 10.1038/nature24157.Peer-Reviewed Original Research