Featured Publications
Transcatheter Aortic Valve Replacement in Low-risk Patients With Bicuspid Aortic Valve Stenosis
Forrest JK, Ramlawi B, Deeb GM, Zahr F, Song HK, Kleiman NS, Chetcuti SJ, Michelena HI, Mangi AA, Skiles JA, Huang J, Popma JJ, Reardon MJ. Transcatheter Aortic Valve Replacement in Low-risk Patients With Bicuspid Aortic Valve Stenosis. JAMA Cardiology 2020, 6: 50-57. PMID: 33031491, PMCID: PMC7542521, DOI: 10.1001/jamacardio.2020.4738.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementBicuspid aortic valve stenosisAortic valve replacementAortic valve stenosisLow-risk patientsDevice success rateValve replacementValve stenosisCause mortalityRandomized trialsAmerican Heart Association/American CollegeSevere bicuspid aortic valve stenosisHigh device success rateLow surgical risk patientsPrespecified primary end pointPrimary efficacy end pointEnd pointBicuspid aortic stenosisMean AV gradientThoracic Surgeons scoreEfficacy end pointPrimary end pointLow surgical riskMild paravalvular leakNew permanent pacemakerPropensity-Matched Outcomes Comparing TAVR in Bicuspid vs Surgery in Tricuspid Aortic Valve Stenosis
Deeb G, Yakubov S, Reardon M, Ramlawi B, Chetcuti S, Kleiman N, Zahr F, Song H, Gada H, Mumtaz M, Ito S, Huang J, Forrest J. Propensity-Matched Outcomes Comparing TAVR in Bicuspid vs Surgery in Tricuspid Aortic Valve Stenosis. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 2: 100525. PMID: 39132531, PMCID: PMC11307701, DOI: 10.1016/j.jscai.2022.100525.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementSurgical aortic valve replacementAortic valve stenosisTricuspid aortic valve stenosisBicuspid aortic valve stenosisAortic valve replacementSAVR patientsValve replacementValve stenosisEvolut Low Risk trialIndependent clinical events committeeLow-risk trialsSerious adverse eventsSevere aortic regurgitationClinical events committeeLow surgical riskLow-risk patientsIndependent core laboratoryEffective orifice areaTAVR groupValve gradientAdverse eventsAortic regurgitationSurgical riskEvents committee
2024
Transcatheter versus surgical aortic valve replacement in lower-risk patients: an updated meta-analysis of randomised controlled trials
Reddy R, Howard J, Reardon M, Thyregod H, Jorgensen T, Toff W, Forrest J, Leon M, Ahmad Y. Transcatheter versus surgical aortic valve replacement in lower-risk patients: an updated meta-analysis of randomised controlled trials. European Heart Journal 2024, 45: ehae666.2456. DOI: 10.1093/eurheartj/ehae666.2456.Peer-Reviewed Original ResearchLower-risk patientsIndividual patient dataFollow-upNo significant differenceClinical outcomesPairwise random-effects meta-analysesNew-onset atrial fibrillationLong-term clinical outcomesSurgical aortic valve replacementKaplan-Meier survival curvesMeta-analysis of randomised controlled trialsLow-surgical riskMeta-analysesAortic valve reinterventionReconstructed individual patient dataLow surgical riskAortic valve replacementFollow-up durationSevere aortic stenosisMeta-analysisSignificant differenceCox proportional hazards regressionComposite of deathKaplan-Meier plotsLonger-term follow-up3-Year Outcomes From the Evolut Low Risk TAVR Bicuspid Study
Zahr F, Ramlawi B, Reardon M, Deeb G, Yakubov S, Song H, Kleiman N, Chetcuti S, Gada H, Mumtaz M, Leung S, Merhi W, Rovin J, DeFrain M, Muppala M, Kauten J, Rajagopal V, Huang J, Ito S, Forrest J. 3-Year Outcomes From the Evolut Low Risk TAVR Bicuspid Study. JACC Cardiovascular Interventions 2024, 17: 1667-1675. PMID: 39048253, DOI: 10.1016/j.jcin.2024.05.017.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisBicuspid Aortic Valve DiseaseBioprosthesisFemaleHeart Valve DiseasesHeart Valve ProsthesisHemodynamicsHumansMaleMiddle AgedPostoperative ComplicationsProspective StudiesProsthesis DesignRecovery of FunctionRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsTranscatheter aortic valve replacementRates of all-cause mortalityAll-cause mortalityAortic stenosisThoracic Surgeons Predicted Risk of Mortality scoreThoracic Surgeons Predicted RiskSevere paravalvular aortic regurgitationBicuspid aortic valve anatomyRisk of Mortality scoreEchocardiographic core laboratoryLow-surgical risk patientsAortic valve anatomyKaplan-Meier ratesLow surgical riskClinical events committeeAortic valve replacementSevere aortic stenosisParavalvular aortic regurgitationPermanent pacemaker implantationBicuspid aortic stenosisFavorable hemodynamic performanceEvaluated 3 yearsAttempted implantEchocardiographic outcomesAortic regurgitation
2023
Three-year outcomes following transcatheter versus surgical aortic valve replacement in younger, low surgical risk patients with severe aortic stenosis
Modine T, Tchetche D, Van Mieghem N, Huang J, Forrest J, Reardon M. Three-year outcomes following transcatheter versus surgical aortic valve replacement in younger, low surgical risk patients with severe aortic stenosis. European Heart Journal 2023, 44: ehad655.1713. DOI: 10.1093/eurheartj/ehad655.1713.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationSevere aortic stenosisSelf-expanding transcatheter aortic valve implantationLow-risk patientsAortic stenosisRisk patientsLower riskCause mortalityPrimary endpointYounger patientsLower incidenceLow surgical risk patientsSurgical aortic valve replacementGreater paravalvular regurgitationSurgical risk patientsAortic stenosis patientsAortic valve replacementIntermediate-term outcomesLow surgical riskAortic valve implantationThree-Year OutcomesEffective orifice areaYears of ageAortic gradientEchocardiographic outcomes
2019
Gender-Related Differences in Transcatheter Aortic Valve Implantation
Stair B, Forrest J. Gender-Related Differences in Transcatheter Aortic Valve Implantation. 2019, 189-200. DOI: 10.1007/978-3-030-05912-5_16.Peer-Reviewed Original ResearchSurgical aortic valve replacementTranscatheter aortic valve implantationAortic valve implantationValve implantationSevere symptomatic aortic stenosisSymptomatic aortic stenosisAortic valve replacementLow surgical riskChronic pressure overloadStandard of careCardiovascular disease statesGender-related differencesTAVR studiesValve replacementAortic stenosisSurgical riskAdverse outcomesPressure overloadRisk factorsTreatment outcomesFemale genderFemale heartsPatientsDisease statesImpact of gender