2024
Exitron splicing of odor receptor genes in Drosophila
Shang X, Talross G, Carlson J. Exitron splicing of odor receptor genes in Drosophila. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2320277121. PMID: 38507450, PMCID: PMC10990081, DOI: 10.1073/pnas.2320277121.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAnimalsDrosophilaOdorantsProtein IsoformsReceptors, OdorantRNA SplicingConceptsExitron splicingOdorant receptor genesCases of alternative splicingCanonical open reading framesExpression of odorant receptor genesFunction of olfactory systemReceptor geneProtein-coding exonsOpen reading frameAlternative splicing eventsOlfactory receptor neuronsAlternative polyadenylationReading frameExon-intronEncode proteinsSplicing eventsAlternative splicingNon-coding RNAsStable proteinsPheromone receptorsReceptor neuronsOptogenetic activationPheromone stimulationSplicingNeuronal activity
2023
Diverse mechanisms of taste coding in Drosophila
Dweck H, Carlson J. Diverse mechanisms of taste coding in Drosophila. Science Advances 2023, 9: eadj7032. PMID: 37976361, PMCID: PMC10656072, DOI: 10.1126/sciadv.adj7032.Peer-Reviewed Original ResearchThe rich non-coding RNA landscape of the Drosophila antenna
Talross G, Carlson J. The rich non-coding RNA landscape of the Drosophila antenna. Cell Reports 2023, 42: 112482. PMID: 37167060, PMCID: PMC10431215, DOI: 10.1016/j.celrep.2023.112482.Peer-Reviewed Original ResearchConceptsDrosophila antennaPheromone-sensing neuronsLong non-coding RNAsNon-coding RNAsDrosophila olfactory systemRole of lncRNAsMultiple complex behaviorsRNA landscapeOlfactory receptor neuronsNeuronal lncRNAsNeural developmentLncRNAsReceptor neuronsModel systemPheromonal responsesOlfactory systemCritical roleNeuron mapNervous systemRNACombination of lncRNAsSpeciationNeuronsRole
2022
Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii
Wang W, Dweck H, Talross G, Zaidi A, Gendron J, Carlson J. Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii. ELife 2022, 11: e81703. PMID: 36398882, PMCID: PMC9674340, DOI: 10.7554/elife.81703.Peer-Reviewed Original ResearchConceptsEgg-laying preferenceTaste organsAgricultural pestsDrosophila suzukiiChannel genesStiff substratesDrosophilaTaste sensillaReceptor geneMechanosensory cuesFruit sugarsGenesMechanosensationTaste sensationBitter taste sensationSpeciesEggsSweet taste sensationMajor subsetSuzukiiPestsSugarsElectrophysiological responsesWeak preferenceVariety of changesIr56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila
Dweck HKM, Talross GJS, Luo Y, Ebrahim SAM, Carlson JR. Ir56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila. Current Biology 2022, 32: 1776-1787.e4. PMID: 35294865, PMCID: PMC9050924, DOI: 10.1016/j.cub.2022.02.063.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDrosophilaDrosophila melanogasterDrosophila ProteinsSodium ChlorideTasteTaste PerceptionConceptsSalt tasteBitter-sensing neuronsStop codonLoss of functionNumber of speciesIonotropic receptorsIonotropic receptor familyN-terminal regionReceptor familyNeuronsDrosophila speciesPremature stop codonTaste modalitiesAncient functionGR familySalt responseSense codonsMolecular basisAtypical memberSalt detectionModalitiesCodonSensory modalitiesDrosophilaBehavioral responses
2021
Sight of parasitoid wasps accelerates sexual behavior and upregulates a micropeptide gene in Drosophila
Ebrahim SAM, Talross GJS, Carlson JR. Sight of parasitoid wasps accelerates sexual behavior and upregulates a micropeptide gene in Drosophila. Nature Communications 2021, 12: 2453. PMID: 33907186, PMCID: PMC8079388, DOI: 10.1038/s41467-021-22712-0.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsAnimals, Genetically ModifiedBeta-Carotene 15,15'-MonooxygenaseCarnivoryDrosophilaDrosophila melanogasterDrosophila ProteinsDrosophila simulansFemaleFertilityGene Expression RegulationMaleNeuronsPattern Recognition, VisualReceptors, Ionotropic GlutamateReceptors, OdorantSexual Behavior, AnimalWaspsConceptsWasp speciesParasitoid waspsParasitoid wasp speciesInsect speciesAdult DrosophilaInsect worldMating behaviorMutational analysisGene expressionFemale fliesWaspsGenesDrosophilaSpeciesFliesDramatic upregulationDefensive responsesWidespread deathVisual circuitsInsectsMicropeptidesBehavioral responsesNervous systemHundreds of thousandsUnexpected responsesEvolutionary shifts in taste coding in the fruit pest Drosophila suzukii
Dweck HK, Talross GJ, Wang W, Carlson JR. Evolutionary shifts in taste coding in the fruit pest Drosophila suzukii. ELife 2021, 10: e64317. PMID: 33616529, PMCID: PMC7899650, DOI: 10.7554/elife.64317.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological EvolutionDrosophilaFragariaFruitOvipositionSensillaSpecies SpecificityTasteConceptsFruit pest Drosophila suzukiiRipe fruitPest Drosophila suzukiiEvolutionary shiftsBitter compoundsLays eggsAgricultural pestsDrosophila suzukiiBitter taste perceptionDrosophilaTaste sensillaSpeciesPhysiological responsesReduced expressionEggsTaste organsSensillaOverripe fruitsFruitTranscriptomeTaste codingSuzukiiMutantsLabellumPests
2019
Molecular Logic and Evolution of Bitter Taste in Drosophila
Dweck HKM, Carlson JR. Molecular Logic and Evolution of Bitter Taste in Drosophila. Current Biology 2019, 30: 17-30.e3. PMID: 31839451, PMCID: PMC6946858, DOI: 10.1016/j.cub.2019.11.005.Peer-Reviewed Original ResearchRobust olfactory responses in the absence of odorant binding proteins
Xiao S, Sun JS, Carlson JR. Robust olfactory responses in the absence of odorant binding proteins. ELife 2019, 8: e51040. PMID: 31651397, PMCID: PMC6814364, DOI: 10.7554/elife.51040.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalDrosophilaOdorantsOlfactory PerceptionReceptors, OdorantSensillaSmellConceptsOdorant binding proteinsOlfactory responsesBinding proteinAntennae of insectsHydrophobic odorantsSensilla typesOlfactory physiologyOlfactory sensillaFunctional typesBasiconic sensillaOBPsAntennal basiconic sensillaOdor receptorsSensillaProteinDiverse chemicalsInsectsOdorantsMutantsBehavioral responsesGenesOvipositionPhysiologyHigh levelsResponse
2016
Bitter taste receptors confer diverse functions to neurons
Delventhal R, Carlson JR. Bitter taste receptors confer diverse functions to neurons. ELife 2016, 5: e11181. PMID: 26880560, PMCID: PMC4764594, DOI: 10.7554/elife.11181.Peer-Reviewed Original Research
2008
A New Drosophila POU Gene, pdm3, Acts in Odor Receptor Expression and Axon Targeting of Olfactory Neurons
Tichy AL, Ray A, Carlson JR. A New Drosophila POU Gene, pdm3, Acts in Odor Receptor Expression and Axon Targeting of Olfactory Neurons. Journal Of Neuroscience 2008, 28: 7121-7129. PMID: 18614681, PMCID: PMC2572001, DOI: 10.1523/jneurosci.2063-08.2008.Peer-Reviewed Original ResearchConceptsPOU genesOlfactory receptor neuronsAxon targetingReceptor gene choiceClasses of ORNsReceptor expressionGenetic interactionsGene choiceGene codesORN classesPdm3Genetic analysisMutational analysisOdor responsesMolecular mechanismsGenesOlfactory neuronsReceptor neuronsIndividual receptorsDifferential activationOlfactory systemProper transmissionExpressionFunctional organizationTargetingTranslation of Sensory Input into Behavioral Output via an Olfactory System
Kreher SA, Mathew D, Kim J, Carlson JR. Translation of Sensory Input into Behavioral Output via an Olfactory System. Neuron 2008, 59: 110-124. PMID: 18614033, PMCID: PMC2496968, DOI: 10.1016/j.neuron.2008.06.010.Peer-Reviewed Original ResearchA Regulatory Code for Neuron-Specific Odor Receptor Expression
Ray A, van Naters W, Carlson JR. A Regulatory Code for Neuron-Specific Odor Receptor Expression. PLOS Biology 2008, 6: e125. PMID: 18846726, PMCID: PMC2430909, DOI: 10.1371/journal.pbio.0060125.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsORN classesAxon guidance genesOdor receptorsAmino acid sequenceMost olfactory receptor neuronsReceptor gene regulationDrosophila speciesPhylogenetic approachGene regulationGenome sequenceTranscription factorsIndividual olfactory receptor neuronsRegulatory elementsAcid sequenceChemosensory organsRegulatory codeGenetic analysisMaxillary palpsGenesLarge repertoireReceptor neuronsReceptor geneExpressionNeuron map
2007
Receptors and Neurons for Fly Odors in Drosophila
van Naters W, Carlson JR. Receptors and Neurons for Fly Odors in Drosophila. Current Biology 2007, 17: 606-612. PMID: 17363256, PMCID: PMC1876700, DOI: 10.1016/j.cub.2007.02.043.Peer-Reviewed Original ResearchConceptsCis-vaccenyl acetateOlfactory receptor neuronsTrichoid sensillaAnti-aphrodisiac pheromoneReceptor gene familyVirgin femalesVivo expression systemGene familyMate recognitionMating partnersDrosophila antennaExpression systemORN populationCellular basisReceptor neuronsYield responseSensillaMale extractsElectrophysiological analysisFood odorsReceptorsDrosophilaMajor typesPheromoneFemalesThe molecular basis of CO2 reception in Drosophila
Kwon JY, Dahanukar A, Weiss LA, Carlson JR. The molecular basis of CO2 reception in Drosophila. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 3574-3578. PMID: 17360684, PMCID: PMC1805529, DOI: 10.1073/pnas.0700079104.Peer-Reviewed Original ResearchConceptsMolecular basisVivo expression systemChemoreceptor genesHigher eukaryotesChemosensory receptorsInsect pestsChemosensory neuronsGene confersExpression systemLarge familyGr63aDrosophilaCO2 receptionGr21aInsectsMosquito vectorsIdentification of agentsEukaryotesPestsReceptorsGenesLarvaeIdentificationYellow feverConfersMechanisms of Odor Receptor Gene Choice in Drosophila
Ray A, van Naters Wv, Shiraiwa T, Carlson JR. Mechanisms of Odor Receptor Gene Choice in Drosophila. Neuron 2007, 53: 353-369. PMID: 17270733, PMCID: PMC1986798, DOI: 10.1016/j.neuron.2006.12.010.Peer-Reviewed Original ResearchConceptsReceptor gene choiceOlfactory receptor neuronsGene choiceNegative regulatory elementAsymmetric segregationAlternative splicingNegative feedback regulationSingle geneTranscription factorsORN classesRegulatory elementsCombinatorial codeDicistronic mRNACommon progenitorMutational analysisDrosophilaRegulatory factorsOlfactory organFeedback regulationOdor receptorsReceptor neuronsReceptor geneGenesNeuron mapReceptor repertoire
2005
The Molecular Basis of Odor Coding in the Drosophila Larva
Kreher SA, Kwon JY, Carlson JR. The Molecular Basis of Odor Coding in the Drosophila Larva. Neuron 2005, 46: 445-456. PMID: 15882644, DOI: 10.1016/j.neuron.2005.04.007.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsDrosophila larvaeMolecular basisVivo expression systemDifferent olfactory systemsFamily of receptorsSingle olfactory receptor neuronsLarval brainSpecificity mapsLarval antennal lobeExpression systemMolecular mechanismsOdor codingOdor receptorsReceptor neuronsIndividual receptorsAntennal lobeLongstanding observationGenesOlfactory systemLarvaeBreadth of tuningSingle glomerulusReceptorsOdor information
2004
The Molecular Basis of Odor Coding in the Drosophila Antenna
Hallem EA, Ho MG, Carlson JR. The Molecular Basis of Odor Coding in the Drosophila Antenna. Cell 2004, 117: 965-979. PMID: 15210116, DOI: 10.1016/j.cell.2004.05.012.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsDrosophila antennaMolecular basisOdorant receptor repertoireFunctional analysisReceptor repertoireOlfactory organOdor codingReceptor neuronsIndividual receptorsSame cellsReceptor transductionNumber of receptorsNeuron mapReceptorsRepertoireBreadth of tuningTransductionDifferent odorantsInhibitory responsesOdorantsElectrophysiological recordingsNeuronsCellsVivo
2003
Integrating the Molecular and Cellular Basis of Odor Coding in the Drosophila Antenna
Dobritsa AA, van Naters W, Warr CG, Steinbrecht RA, Carlson JR. Integrating the Molecular and Cellular Basis of Odor Coding in the Drosophila Antenna. Neuron 2003, 37: 827-841. PMID: 12628173, DOI: 10.1016/s0896-6273(03)00094-1.Peer-Reviewed Original ResearchConceptsAb3A neuronsEctopic expressionTransgenic rescue experimentsWild-type cellsDrosophila olfactory systemOdor ligandsDeletion mutantsDrosophila antennaCells identifiesGene expressionRescue experimentsCellular mapsSexual dimorphismReceptor gene expressionCellular basisOr22aOdor receptorsReceptor geneSingle cellsGenesOlfactory systemExpressionOdor codingDendritic membraneCells
2001
A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila
Dahanukar A, Foster K, van der Goes van Naters W, Carlson J. A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila. Nature Neuroscience 2001, 4: 1182-1186. PMID: 11704765, DOI: 10.1038/nn765.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, Genetically ModifiedBase SequenceBehavior, AnimalCodonDose-Response Relationship, DrugDrosophilaFood, FormulatedGene DeletionGene Expression RegulationGenetic LinkageGTP-Binding ProteinsMaleMutationNeurons, AfferentPhenotypeProtein BiosynthesisReceptors, Cell SurfaceSucroseTasteTrehaloseX ChromosomeConceptsGR geneG protein-coupled receptor genesSugar trehaloseG protein-mediated signalingDrosophila genome databaseTransgenic rescue experimentsProtein-mediated signalingSpecificity of expressionGenome databaseTaste receptorsDifferent mutantsRescue experimentsGenesLarge familyGr5aDrosophilaFunctional evidenceReceptor geneGR receptorsTaste ligandsGustatory neuronsTaste neuronsTrehaloseReceptorsFamily members