2015
Malaria Parasites Produce Volatile Mosquito Attractants
Kelly M, Su CY, Schaber C, Crowley JR, Hsu FF, Carlson JR, Odom AR. Malaria Parasites Produce Volatile Mosquito Attractants. MBio 2015, 6: 10.1128/mbio.00235-15. PMID: 25805727, PMCID: PMC4453533, DOI: 10.1128/mbio.00235-15.Peer-Reviewed Original ResearchConceptsMalaria parasitesMalaria mosquito vector Anopheles gambiaeNonphotosynthetic plastid organelleMosquito vector Anopheles gambiaeMalaria parasite Plasmodium falciparumIsoprenoid biosynthesis pathwayParasite Plasmodium falciparumTransmission-blocking strategiesPlastid organelleBiosynthesis pathwayVolatile signalsOdorant receptorsCultured malaria parasitesVolatile chemical profilesMammalian hostsMosquito attractantsAnopheles gambiaeChemical signalsHost attractionMolecular identityMetabolic pathwaysVolatile odorantsParasitesGlobal health concernPlasmodium falciparum
2005
Coexpression of Two Functional Odor Receptors in One Neuron
Goldman AL, van Naters W, Lessing D, Warr CG, Carlson JR. Coexpression of Two Functional Odor Receptors in One Neuron. Neuron 2005, 45: 661-666. PMID: 15748842, DOI: 10.1016/j.neuron.2005.01.025.Peer-Reviewed Original Research
2003
Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster
Robertson HM, Warr CG, Carlson JR. Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14537-14542. PMID: 14608037, PMCID: PMC304115, DOI: 10.1073/pnas.2335847100.Peer-Reviewed Original ResearchConceptsMolecular evolutionDrosophila melanogasterGustatory receptor proteinsAlternative splice formsN-terminal exonsGR geneChemoreceptor genesTandem clustersAncestral intronsAncient superfamilyDrosophila genomeIntron evolutionDivergent cladesAdditional intronPolymorphic pseudogenesInsect chemoreceptorCommon ancestorAlternative splicingPhylogenetic analysisGR familyOdorant receptorsSplice formsX chromosomeSugar trehaloseIntrons
1999
A Novel Family of Divergent Seven-Transmembrane Proteins Candidate Odorant Receptors in Drosophila
Clyne P, Warr C, Freeman M, Lessing D, Kim J, Carlson J. A Novel Family of Divergent Seven-Transmembrane Proteins Candidate Odorant Receptors in Drosophila. Neuron 1999, 22: 327-338. PMID: 10069338, DOI: 10.1016/s0896-6273(00)81093-4.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsPOU domain transcription factorLarge multigene familyCandidate odorant receptorsTransmembrane domain proteinGenomic sequence databasesSubset of ORNsDomain proteinsMultigene familyAntennal developmentOdorant receptorsTranscription factorsSequence databasesInitiate expressionOlfactory organOdorant specificityNovel familyDifferent membersReceptor neuronsReceptor moleculesInsectsMutantsValuable modelGenesOlfactory system