2011
Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians
Li D, Zhao H, Gelernter J. Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians. Human Genetics 2011, 131: 725-737. PMID: 22102315, PMCID: PMC3548401, DOI: 10.1007/s00439-011-1116-4.Peer-Reviewed Original ResearchConceptsAlcohol dependenceAlcohol-induced liver diseaseStrong associationCase-control studyPathogenesis of ADSub-group analysisStrong protective effectRandom-effects modelP-valueAldehyde dehydrogenase 2 geneLiver diseaseMedical illnessMedical diseasesProtective effectAlcohol abuseLys alleleAcetaldehyde metabolismAsian populationsStatistical significanceStrict criteriaALDH2 geneEffects modelAssociationDiseaseDominant model
2006
Diplotype Trend Regression Analysis of the ADH Gene Cluster and the ALDH2 Gene: Multiple Significant Associations with Alcohol Dependence
Luo X, Kranzler HR, Zuo L, Wang S, Schork NJ, Gelernter J. Diplotype Trend Regression Analysis of the ADH Gene Cluster and the ALDH2 Gene: Multiple Significant Associations with Alcohol Dependence. American Journal Of Human Genetics 2006, 78: 973-987. PMID: 16685648, PMCID: PMC1474098, DOI: 10.1086/504113.Peer-Reviewed Original ResearchConceptsADH gene clusterGene clusterAldehyde dehydrogenase geneStructured association analysisConventional association methodsALDH2 geneAlcohol dehydrogenaseAdh geneDehydrogenase geneAssociation analysisSusceptibility lociGenesRisk genesFunctional variantsDisease allelesFunctional complexityCase-control sampleAncestry informative markersHardy-Weinberg equilibrium testDisequilibrium measuresMultiple significant associationsAllelesAlcohol-metabolizing enzymesConventional case-control comparisonsUnlinked ancestry-informative markers