2022
Parental Age and Childhood Risk for Cerebral Palsy in California
Zhou L, Meng Q, von Ehrenstein O, Xiao J, Gao Y, Wu Y, Ritz B, Liew Z. Parental Age and Childhood Risk for Cerebral Palsy in California. The Journal Of Pediatrics 2022, 255: 147-153.e6. PMID: 36372095, PMCID: PMC10121738, DOI: 10.1016/j.jpeds.2022.10.039.Peer-Reviewed Original ResearchConceptsCerebral palsyPaternal ageGreater riskPreterm birthMaternal ageParental ageRisk of CPYoung maternal ageBirth certificate recordsCase-control studyTime of deliveryChildren of mothersOlder paternal ageCP diagnosisPreterm deliveryOffspring riskCertificate recordsCP casesCP riskSingleton controlsAge 20Older mothersAge 25Older ageChildhood risk
2021
Associations of parental birth characteristics with autism spectrum disorder (ASD) risk in their offspring: a population-based multigenerational cohort study in Denmark
Xiao J, Gao Y, Yu Y, Toft G, Zhang Y, Luo J, Xia Y, Chawarska K, Olsen J, Li J, Liew Z. Associations of parental birth characteristics with autism spectrum disorder (ASD) risk in their offspring: a population-based multigenerational cohort study in Denmark. International Journal Of Epidemiology 2021, 50: 485-495. PMID: 33411909, PMCID: PMC8128455, DOI: 10.1093/ije/dyaa246.Peer-Reviewed Original ResearchConceptsBirth characteristicsAutism spectrum disorder (ASD) riskCohort studyOdds ratioNationwide register-based cohort studySociodemographic factorsRegister-based cohort studyOffspring of mothersConfidence intervalsASD riskHealth-related factorsExposure risk factorsDisorder riskLogistic regression modelsOffspring of parentsPerinatal factorsPreterm birthFather-child pairsLow birthweightVery pretermEpidemiological evidenceRisk factorsHigh riskElevated riskPaternal factors
2020
Association of Grandparental and Parental Age at Childbirth With Autism Spectrum Disorder in Children
Gao Y, Yu Y, Xiao J, Luo J, Zhang Y, Tian Y, Zhang J, Olsen J, Li J, Liew Z. Association of Grandparental and Parental Age at Childbirth With Autism Spectrum Disorder in Children. JAMA Network Open 2020, 3: e202868. PMID: 32293683, PMCID: PMC7160691, DOI: 10.1001/jamanetworkopen.2020.2868.Peer-Reviewed Original ResearchConceptsGrandparental ageAdvanced parental ageParental ageOdds ratioDanish national health registriesMaternal age 40 yearsMultigenerational cohortASD riskDanish Psychiatric Central RegisterAutism spectrum disorderNational health registriesAge 40 yearsAge 50 yearsPsychiatric Central RegisterRisk of ASDLogistic regression analysisPaternal grandmotherTime of birthCentral RegisterCohort studyHealth registriesMaternal ageSingleton childrenMAIN OUTCOMESpectrum disorder