Featured Publications
Adverse Childhood Experiences (ACEs) in Unhoused Children Increase Odds of Psychiatric Illness, Physical Illness, and Psychiatric Admission
Pan, E.J., Liu, J.C., Zha, A.C. et al. Adverse Childhood Experiences (ACEs) in Unhoused Children Increase Odds of Psychiatric Illness, Physical Illness, and Psychiatric Admission. Journ Child Adol Trauma (2024). https://doi.org/10.1007/s40653-023-00608-zPeer-Reviewed Original ResearchRegular cannabis use is associated with history of childhood and lifetime trauma in a non-clinical community sample
Bassir Nia A, Weleff J, Fogelman N, Nourbakhsh S, Sinha R. Regular cannabis use is associated with history of childhood and lifetime trauma in a non-clinical community sample. Journal Of Psychiatric Research 2023, 159: 159-164. PMID: 36736285, PMCID: PMC10024801, DOI: 10.1016/j.jpsychires.2023.01.036.Peer-Reviewed Original ResearchConceptsMajor life eventsChildhood traumaLife eventsChildhood Trauma QuestionnaireLifetime traumaCannabis useNon-clinical community sampleChronic stressNeurobiology of stressRegular cannabis useGender differencesRegular useSelf-report questionnairesRecent life eventsPotential gender differencesCross-sectional studyUrine drug testingLife traumaLogistic regression analysisAdversity indexCommunity sampleCannabis usersTrauma QuestionnaireHigh rateSubstance useKey Updates to Understanding Roles of Childhood Trauma in Overall Health.
Weleff J, Potter D. Key Updates to Understanding Roles of Childhood Trauma in Overall Health. The AMA Journal Of Ethic 2023, 25: e116-122. PMID: 36754073, DOI: 10.1001/amajethics.2023.116.Peer-Reviewed Original ResearchClinical Presentations and Treatment of Phenibut Toxicity and Withdrawal: A Systematic Literature Review.
Weleff J, Kovacevich A, Burson J, Nero N, Anand A. Clinical Presentations and Treatment of Phenibut Toxicity and Withdrawal: A Systematic Literature Review. J Addict Med 2023 PMID: 36745903, DOI: 10.1097/ADM.0000000000001141.Peer-Reviewed Original ResearchEmergency services utilization by patients with alcohol‐associated hepatitis: An analysis of national trends
Sengupta S, Anand A, Lopez R, Weleff J, Wang P, Bellar A, Attaway A, Welch N, Dasarathy S. Emergency services utilization by patients with alcohol‐associated hepatitis: An analysis of national trends. Alcohol Clinical And Experimental Research 2024, 48: 98-109. PMID: 38193831, PMCID: PMC10783841, DOI: 10.1111/acer.15223.Peer-Reviewed Original ResearchAlcohol-associated hepatitisNationwide Emergency Department SampleEmergency departmentRate of ED visitsED visitsLiver diseaseProportion of young patientsComplications of liver diseaseSeverity of diseaseED utilizationAH diagnosisPrimary AHPatients seeking careOutcome of ED visitsYounger patientsHighest rate of ED visitsEmergency Department SampleSevere formHospitalized patientsTemporal trendsPatientsEmergency service utilizationED utilization ratesRate of visitsLogistic regressionThe Zero Suicide Model in Addiction Treatment Settings: Recognizing the Need for Feasibility and Implementation Data
Arakelian M, Barnett B, Weleff J. The Zero Suicide Model in Addiction Treatment Settings: Recognizing the Need for Feasibility and Implementation Data. Psychiatric Services 2023, 75: 378-380. PMID: 37933133, DOI: 10.1176/appi.ps.20230175.Peer-Reviewed Original ResearchConceptsAddiction treatment settingsTreatment settingsZero SuicideSubstance use disordersZero Suicide modelAddiction outcomesUse disorderSuicide modelsAddiction treatmentHealth care settingsAddictionHealth care systemSuicide preventionSuicideImplement best practicesCare settingsCare systemOpen ForumIncreased riskBest practicesHealthDisordersSetsResearchCliniciansReported firearm access among patients admitted to a dual diagnosis medically-assisted withdrawal unit over five years
Weleff, J., Butler, R.S., Streem, D, & Barnett, B.S. Reported firearm access among patients admitted to a dual diagnosis medically-assisted withdrawal unit over five years. Drug and Alcohol Dependence Reports. 2022. 2, 100034. DOI: https://doi.org/10.1016/j.dadr.2022.100034Peer-Reviewed Original ResearchDysregulation of the endogenous cannabinoid system following opioid exposure
Mohammad Aghaei A, Saali A, Canas M, Weleff J, D'Souza D, Angarita G, Bassir Nia A. Dysregulation of the endogenous cannabinoid system following opioid exposure. Psychiatry Research 2023, 330: 115586. PMID: 37931479, PMCID: PMC10842415, DOI: 10.1016/j.psychres.2023.115586.Peer-Reviewed Original ResearchConceptsEndocannabinoid systemECS componentsBrain regionsNovel neurobiological targetsTreatment of OUDEndogenous opioid systemOpioid-related deathsEndogenous cannabinoid systemSpecific brain regionsECS dysregulationOpioid exposureOUD treatmentOpioid systemCannabinoid systemNeurobiological targetsNew medicationsPreclinical literatureCannabinoid receptorsEndogenous ligandTherapeutic potentialStudy typePresent potential targetsExposure protocolOpioidsPreclinical researchRace, economic status, and disparities in the receipt of benzodiazepine prescriptions in a large primary care sample
Dore S, Weleff J, Anand A, Thompson N, Barnett B. Race, economic status, and disparities in the receipt of benzodiazepine prescriptions in a large primary care sample. General Hospital Psychiatry 2023, 85: 28-34. PMID: 37729721, DOI: 10.1016/j.genhosppsych.2023.09.002.Peer-Reviewed Original ResearchConceptsAmerican patientsAsian American patientsPatient characteristicsBenzodiazepine prescriptionsWhite patientsCohort of patientsEconomic statusMultivariate logistic regressionAfrican American patientsPrescription of benzodiazepinesLow-income zip codesPatient's economic statusPrimary care contextPrimary care samplePrimary care visitsPrimary care clinicsLower-income patientsRetrospective studyPrescribed benzodiazepinesPatientsBenzodiazepinesCare sampleBenzodiazepine prescribingCare clinicsCare visitsClinical Presentations and Treatment of Phenibut Toxicity and Withdrawal: A Systematic Literature Review
Weleff J, Kovacevich A, Burson J, Nero N, Anand A. Clinical Presentations and Treatment of Phenibut Toxicity and Withdrawal: A Systematic Literature Review. Journal Of Addiction Medicine 2023, 17: 407-417. PMID: 37579098, DOI: 10.1097/adm.0000000000001141.Peer-Reviewed Original ResearchConceptsWithdrawal casesClinical presentationConcomitant substance useLength of hospital stayAverage length of hospital staySystematic treatment protocolCochrane Library databasesAtypical antipsychoticsComprehensive literature searchSubstance useAddictive agentHospital stayPublished casesBenzodiazepinesPhenibutLibrary databasesToxicity casesAntipsychoticsTreatment protocolsPsychosisWithdrawalMultiple medicationsAverage ageMental statusMovement disordersAn Analysis of Benzodiazepine Prescribing to Primary Care Patients in a Large Healthcare System from 2019-2020
Weleff J, Anand A, Squeri M, Sieke R, Thompson N, Barnett B. An Analysis of Benzodiazepine Prescribing to Primary Care Patients in a Large Healthcare System from 2019-2020. Journal Of Psychoactive Drugs 2023, 56: 245-256. PMID: 36940298, DOI: 10.1080/02791072.2023.2191610.Peer-Reviewed Original ResearchConceptsBenzodiazepine prescribingBenzodiazepine prescriptionsPrimary care visitsPrimary care patientsPrimary care providersEffect sizePrimary care settingPost-lockdownBenzodiazepine prescribing ratesMultivariate logistic regressionCare visitsCare providersCare settingsPrescription receiptRetrospective cohort studyCare patientsRacial disparitiesPrescribing ratesNational ratesHealthcare systemAdult patientsDiagnosis codesCocaine use disorderCohort studyPrescribingWhy Harm Reduction and Equity Are Ethical Imperatives in Opioid Use Disorder Care.
Weleff J. Why Harm Reduction and Equity Are Ethical Imperatives in Opioid Use Disorder Care. The AMA Journal Of Ethic 2024, 26: e509-511. PMID: 38958418, DOI: 10.1001/amajethics.2024.509.Peer-Reviewed Original Research
2024
Navigating new norms: Addiction specialists' perspectives on opioid use disorder treatments and policy challenges in the fentanyl era
Weleff J, Christian N, Wang J, Singh M, De Aquino J, Saxon A, Vassallo G. Navigating new norms: Addiction specialists' perspectives on opioid use disorder treatments and policy challenges in the fentanyl era. American Journal On Addictions 2024 PMID: 39364597, DOI: 10.1111/ajad.13653.Peer-Reviewed Original ResearchSlow-release oral morphineOpioid use disorderBarriers to OUD treatmentAddiction specialistsOpioid use disorder managementUse disorderOUD treatmentThird-line monotherapyFisher's exact testOpioid use disorder treatmentOff-label prescribingOral morphineAgonist opioidsOpioid agonistsOpioid-related overdoseTherapeutic optionsWithdrawal symptomsNovel therapiesExact testOpioidMOUD prescribingSynthetic opioidsClinical practiceClinical approachCompare respondent characteristicsOverlooked Benefits, Risks, and Assumptions of AI Integration in Pediatric Care—Reply
Pratt N, Madhavan R, Weleff J. Overlooked Benefits, Risks, and Assumptions of AI Integration in Pediatric Care—Reply. JAMA Pediatrics 2024, 178: 953-953. PMID: 39037831, DOI: 10.1001/jamapediatrics.2024.2290.Peer-Reviewed Original ResearchInductive thematic analysis of healthcare qualitative interviews using open-source large language models: How does it compare to traditional methods?
Mathis W, Zhao S, Pratt N, Weleff J, De Paoli S. Inductive thematic analysis of healthcare qualitative interviews using open-source large language models: How does it compare to traditional methods? Computer Methods And Programs In Biomedicine 2024, 255: 108356. PMID: 39067136, DOI: 10.1016/j.cmpb.2024.108356.Peer-Reviewed Original ResearchLanguage modelThematic analysisInductive thematic analysisQualitative thematic analysisGenerative artificial intelligenceSemi-structured interviewsLocal hardwareArtificial intelligenceHealth informationReal worldPsychiatric settingsHuman codingQualitative interviewsQualitative dataEvaluation methodologyQuantify similarityRobust themesThemesResearch settingsTraditional methodsEngineering techniquesInterviewsEvaluation methodQualitative researchCorpus of interviewsWernicke’s encephalopathy treated with high dose intravenous thiamine: a case report
Alamir M, Cantu-Weinstein A, Branning R, Weleff J, Anand A. Wernicke’s encephalopathy treated with high dose intravenous thiamine: a case report. Journal Of Addictive Diseases 2024, ahead-of-print: 1-6. PMID: 38946394, DOI: 10.1080/10550887.2024.2365002.Peer-Reviewed Original ResearchAlcohol use disorderWernicke's encephalopathyIV thiamineSymptoms of Wernicke's encephalopathySevere alcohol use disorderFirst-line treatmentLow-risk treatmentTreat neurological symptomsUse disorderHigh-doseCognitive dysfunctionCase reportStandard treatmentNeurological symptomsTreatment guidelinesOptimal doseHigh dosesThiamine deficiencyMental statusDoseChronic malnourishmentTreatmentSymptomsWernickeOphthalmoplegiaPrevalence of Patient Suicide and Its Impact on Health Care Professionals: A Systematic Review
Jupina M, Mercer M, Weleff J, Hackett L, Nunes J, Sebastian D, Anand A. Prevalence of Patient Suicide and Its Impact on Health Care Professionals: A Systematic Review. Psychiatric Services 2024, 75: 999-1008. PMID: 39350634, DOI: 10.1176/appi.ps.20230351.Peer-Reviewed Original ResearchPerceived Risk of Trying Lysergic Acid Diethylamide in the United States from 2015 to 2019: Are Americans Assessing Lysergic Acid Diethylamide's Risk Profile More Favorably?
Barnett B, Anand A, Dewey E, Smith D, Nayak S, Bruckman D, Weleff J. Perceived Risk of Trying Lysergic Acid Diethylamide in the United States from 2015 to 2019: Are Americans Assessing Lysergic Acid Diethylamide's Risk Profile More Favorably? Psychedelic Medicine 2024, 2: 74-86. DOI: 10.1089/psymed.2023.0027.Peer-Reviewed Original ResearchNational Survey on Drug Use and HealthDrug Use and HealthLysergic acid diethylamideUnited StatesSurvey yearSexual minoritiesYear suicide attemptMale genderRespondents' ageScholarly workAcid diethylamideMultivariate modelRisk profileGenderPerceived riskHigher education levelProportion of respondentsEducation levelStatistically significant associationGeneral publicPsychological distressReply to Sato et al. Letter to the Editor: Diagnosis and treatment of Wernicke's encephalopathy: A systematic literature review
Cantu-Weinstein A, Weleff J, Nero N, Anand A. Reply to Sato et al. Letter to the Editor: Diagnosis and treatment of Wernicke's encephalopathy: A systematic literature review. General Hospital Psychiatry 2024, 90: 189-190. PMID: 38852009, DOI: 10.1016/j.genhosppsych.2024.05.012.Peer-Reviewed Original ResearchChanges in Emergency Department Utilization in Vulnerable Populations After COVID-19 Shelter-in-Place Orders
Wang P, Anand A, Bena J, Morrison S, Weleff J. Changes in Emergency Department Utilization in Vulnerable Populations After COVID-19 Shelter-in-Place Orders. Cureus 2024, 16: e60556. PMID: 38887338, PMCID: PMC11182374, DOI: 10.7759/cureus.60556.Peer-Reviewed Original ResearchSocial determinants of healthSubstance use disordersElectronic medical recordsED utilizationEmergency departmentMH disordersDocumenting social determinants of healthMental healthVulnerable populationsDeterminants of healthRate of hospital admissionsEmergency department utilizationHistory of mental healthIntegrated healthcare systemMedical recordsCompare emergency departmentShelter-in-placeIncreased ED utilizationLogistic regression modelsCOVID-19 shelter-in-placePatients' medical recordsED careSocial determinantsPublic health crisisZ codes