Jeremy Puthumana, MD, MS
Clinical FellowDownloadHi-Res Photo
About
Titles
Clinical Fellow
Departments & Organizations
- ABIM Physician-Scientist Research Pathway
- Internal Medicine
Education & Training
- Resident
- Yale New Haven Hospital
- MD
- Yale School of Medicine
- MS
- Yale University
- BS
- Yale University
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jeremy Puthumana's published research.
Chirag Parikh, MD, PhD, FACP
Pramod Mistry, MBBS, PhD, MA, MD
TuKiet Lam, PhD, BS
Publications
2024
Systematic Review and Meta-Analysis of Urine Neutrophil Gelatinase–Associated Lipocalin for Acute Kidney Injury in Cirrhosis
Puthumana J, Lugon N, Xu Y, Deng Y, Mistry P, Parikh C, Consortium T, Angeli P, Belcher J, Gambino C, Salaheldin M, Treepraertsuk S. Systematic Review and Meta-Analysis of Urine Neutrophil Gelatinase–Associated Lipocalin for Acute Kidney Injury in Cirrhosis. Kidney International Reports 2024, 9: 2278-2281. PMID: 39081737, PMCID: PMC11284356, DOI: 10.1016/j.ekir.2024.04.050.Peer-Reviewed Original ResearchAltmetric
2014
Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation
Shibata S, Arroyo JP, Castañeda-Bueno M, Puthumana J, Zhang J, Uchida S, Stone KL, Lam TT, Lifton RP. Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 15556-15561. PMID: 25313067, PMCID: PMC4217463, DOI: 10.1073/pnas.1418342111.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAdaptor Proteins, Signal TransducingAmino Acid SequenceAngiotensin IIAnimalsCarrier ProteinsCell LineHumansKidneyMice, Inbred C57BLMicrofilament ProteinsMolecular Sequence DataPhosphorylationPhosphoserineProtein BindingProtein Kinase CProtein Serine-Threonine KinasesProteolysisSignal TransductionConceptsRenal salt reabsorptionAngiotensin IIVolume depletionSalt reabsorptionNormal physiologic responseProtein kinase CAII administrationBlood pressureCardiovascular diseaseGlobal burdenPhysiologic responsesCullin 3Kinase CNaCl cotransporterReabsorptionHuman genetic studiesSecretionHypertensionNormal mechanismsWNK4 degradationMissense mutationsSerine 433WNK4Inverse relationshipCultured cells
2013
Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4
Shibata S, Zhang J, Puthumana J, Stone KL, Lifton RP. Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 7838-7843. PMID: 23576762, PMCID: PMC3651502, DOI: 10.1073/pnas.1304592110.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCarrier ProteinsChlorocebus aethiopsCOS CellsCullin ProteinsElectrolytesGene Expression RegulationHomeostasisHumansIntracellular Signaling Peptides and ProteinsMicrofilament ProteinsMinor Histocompatibility AntigensMutationPotassium Channels, Inwardly RectifyingProtein BindingProtein Serine-Threonine KinasesProteomicsPseudohypoaldosteronismUbiquitinUbiquitinationWNK Lysine-Deficient Protein Kinase 1ConceptsPseudohypoaldosteronism type IICullin 3Disease-causing mutationsWNK4 levelsE3 ubiquitin ligase complexUbiquitin ligase complexDominant disease-causing mutationsRare Mendelian syndromePHAII-causing mutationsLigase complexTarget ubiquitinationUbiquitinationRenal salt reabsorptionMolecular explanationMendelian syndromesSpecific substratesCell surfaceWNK4Renal outer medullaryMutationsProtein levelsKelchKLHL3Specific roleElectrolyte homeostasisSun protection practices among melanoma survivors
Puthumana J, Ferrucci L, Mayne S, Lannin D, Chagpar A. Sun protection practices among melanoma survivors. [abstract] Cancer Research. 2013;73(8 Suppl):1365.Peer-Reviewed Original Research