2024
Selective utilization of glucose metabolism guides mammalian gastrulation
Cao D, Bergmann J, Zhong L, Hemalatha A, Dingare C, Jensen T, Cox A, Greco V, Steventon B, Sozen B. Selective utilization of glucose metabolism guides mammalian gastrulation. Nature 2024, 634: 919-928. PMID: 39415005, PMCID: PMC11499262, DOI: 10.1038/s41586-024-08044-1.Peer-Reviewed Original ResearchConceptsCellular metabolismMammalian gastrulationHexosamine biosynthetic pathwayTranscription factor networksCellular signaling pathwaysSignaling morphogensGlucose metabolismCellular programmeBiosynthetic pathwayFate acquisitionCell fateHousekeeping natureGenetic mechanismsMesoderm migrationFactor networksERK activationExpression patternsSignaling pathwayDevelopmental processesStem cell modelCell typesSpecialized functionsDevelopmental contextMammalian embryosMouse embryos
2023
Colonization of Honey Bee Digestive Tracts by Environmental Yeast Lachancea thermotolerans Is Naturally Occurring, Temperature Dependent, and Impacts the Microbiome of Newly Emerged Bees
Kogan H, Elikan A, Glaser K, Bergmann J, Raymond L, Prado-Irwin S, Snow J. Colonization of Honey Bee Digestive Tracts by Environmental Yeast Lachancea thermotolerans Is Naturally Occurring, Temperature Dependent, and Impacts the Microbiome of Newly Emerged Bees. Microbiology Spectrum 2023, 11: e05194-22. PMID: 36790179, PMCID: PMC10100982, DOI: 10.1128/spectrum.05194-22.Peer-Reviewed Original ResearchHoney bee healthBee healthHoney beesYeast Lachancea thermotoleransHoney bee midgutLachancea thermotoleransEnvironmental yeastHoney bee diseasesHoney bee coloniesDigestive tractAssociation of fungiAgricultural pollinationBee midgutCritical pollinatorsBee diseasesYeast speciesFungal speciesYoung beesColony temperatureBeesYeastEnvironmental stressorsMicrobial attackL. thermotoleransEcological settings
2022
Hoxa5 Activity Across the Lateral Somitic Frontier Regulates Development of the Mouse Sternum
Mitchel K, Bergmann JM, Brent AE, Finkelstein TM, Schindler KA, Holzman MA, Jeannotte L, Mansfield JH. Hoxa5 Activity Across the Lateral Somitic Frontier Regulates Development of the Mouse Sternum. Frontiers In Cell And Developmental Biology 2022, 10: 806545. PMID: 35557949, PMCID: PMC9086245, DOI: 10.3389/fcell.2022.806545.Peer-Reviewed Original ResearchLateral somitic frontierLateral plate mesodermSkeletal patterningTissue-specific contributionsPlate mesodermEmbryonic precursorsGenetic controlProper developmentHOXA5 expressionEmbryonic sourcesRegulate DevelopmentSkeletal phenotypeConditional deletionEmbryological informationMultiple rolesMesodermSkeletal systemHoxSomitesTheriansPrimordiaAdditive roleRegulatorDeletionMost aspects
2021
HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation
Holzman MA, Ryckman A, Finkelstein TM, Landry-Truchon K, Schindler KA, Bergmann JM, Jeannotte L, Mansfield JH. HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation. Frontiers In Cell And Developmental Biology 2021, 9: 632303. PMID: 33732701, PMCID: PMC7959767, DOI: 10.3389/fcell.2021.632303.Peer-Reviewed Original ResearchSkeletal muscle fateNull mutant embryosBAT developmentBrown adipocyte differentiationEmbryonic day 12.5Muscle fateBrown adipose tissueSkeletal muscleMutant embryosHOXA5 proteinLipid droplet morphologyForelimb levelEmbryonic developmentMolecular roleMuscle developmentLineage tracingMuscle patterningCommon progenitorDependent regulationMuscle phenotypeAdipocyte differentiationMultiple tissuesConditional deletionDay 12.5Progenitors
2018
HOXA5 protein expression and genetic fate mapping show lineage restriction in the developing musculoskeletal system
Holzman MA, Bergmann JM, Feldman M, Landry-Truchon K, Jeannotte L, Mansfield JH. HOXA5 protein expression and genetic fate mapping show lineage restriction in the developing musculoskeletal system. The International Journal Of Developmental Biology 2018, 62: 785-796. PMID: 30604848, PMCID: PMC8783609, DOI: 10.1387/ijdb.180214jm.Peer-Reviewed Original ResearchConceptsLateral plate mesodermHOXA5 expressionSkeletal patterningPlate mesodermNon-cell autonomous functionCell-autonomous roleProtein expressionSatellite cell lineageLineage restrictionGenetic lineagesEmbryonic cellsCell lineagesLateral sclerotomeTissue specificitySomite stageSkeletal developmentLineagesAutonomous roleDirect roleMusculoskeletal morphologyTissue typesMesodermHOXA5SomitesAutonomous functions