Jaya Prakash Golla, PhD
Associate Research Scientist (Endocrinology)Cards
About
Research
Publications
2023
Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition
Sakuma I, Gaspar R, Luukkonen P, Kahn M, Zhang D, Zhang X, Murray S, Golla J, Vatner D, Samuel V, Petersen K, Shulman G. Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2312666120. PMID: 38127985, PMCID: PMC10756285, DOI: 10.1073/pnas.2312666120.Peer-Reviewed Original Research
2022
Lipidomics and Redox Lipidomics Indicate Early Stage Alcohol‐Induced Liver Damage
Koelmel JP, Tan WY, Li Y, Bowden JA, Ahmadireskety A, Patt AC, Orlicky DJ, Mathé E, Kroeger NM, Thompson DC, Cochran JA, Golla JP, Kandyliari A, Chen Y, Charkoftaki G, Guingab‐Cagmat J, Tsugawa H, Arora A, Veselkov K, Kato S, Otoki Y, Nakagawa K, Yost RA, Garrett TJ, Vasiliou V. Lipidomics and Redox Lipidomics Indicate Early Stage Alcohol‐Induced Liver Damage. Hepatology Communications 2022, 6: 513-525. PMID: 34811964, PMCID: PMC8870008, DOI: 10.1002/hep4.1825.Peer-Reviewed Original ResearchConceptsAlcoholic fatty liver diseaseEthanol-treated miceFatty liver diseaseAlcohol consumption altersRegulation of triglycerideLiver lipidomeRegulation of phosphatidylcholineHepatic inflammationLiver biopsyLiver diseaseComprehensive time-course studyLiver damageHistological signsEarly biomarkersHistological markersMouse modelTime-course studyLiver tissueTriglyceridesHistological analysisEarly detectionLipid accumulationLiverMajor lipid classesDiet model
2021
Molecular Mechanisms of Alcohol-Induced Colorectal Carcinogenesis
Johnson CH, Golla JP, Dioletis E, Singh S, Ishii M, Charkoftaki G, Thompson DC, Vasiliou V. Molecular Mechanisms of Alcohol-Induced Colorectal Carcinogenesis. Cancers 2021, 13: 4404. PMID: 34503214, PMCID: PMC8431530, DOI: 10.3390/cancers13174404.Peer-Reviewed Original ResearchColorectal cancerColorectal carcinogenesisChronic alcohol consumptionMost CRC patientsSporadic colorectal cancerGenetic risk factorsEffects of alcoholBacterial translocationCRC patientsFamilial cancer syndromeIntestinal permeabilityRisk factorsAlcohol consumptionCancer syndromesCRC modelMechanisms of alcoholAlcohol metabolitesGermline mutationsOne-carbon metabolismExact mechanismReactive oxygen speciesSporadic cancersCarcinogenesisImmunosuppressionCancerImpaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function
Thompson B, Chen Y, Davidson EA, Garcia-Milian R, Golla JP, Apostolopoulos N, Orlicky DJ, Schey K, Thompson DC, Vasiliou V. Impaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function. The Ocular Surface 2021, 22: 190-203. PMID: 34425299, PMCID: PMC8560581, DOI: 10.1016/j.jtos.2021.08.010.Peer-Reviewed Original ResearchConceptsHEK293T cellsEye developmentGSH biosynthesisTransactivation activityPax6 functionReactive oxygen speciesSubsequent gene ontologyCell identity genesButhionine sulfoximineEpithelial cell identityRNA-seq analysisIngenuity Pathway AnalysisKey upstream regulatorIdentity genesCell identityGene OntologyRNA-seqImmune response genesBioinformatics analysisResponse genesGlutathione biosynthesisLens morphogenesisMolecular consequencesUpstream regulatorMicrophthalmia phenotypeIdentification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach
Charkoftaki G, Golla JP, Santos-Neto A, Orlicky DJ, Garcia-Milian R, Chen Y, Rattray NJW, Cai Y, Wang Y, Shearn CT, Mironova V, Wang Y, Johnson CH, Thompson DC, Vasiliou V. Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach. Toxicological Sciences 2021, 183: 338-351. PMID: 33693819, PMCID: PMC8921626, DOI: 10.1093/toxsci/kfab030.Peer-Reviewed Original ResearchConceptsDX exposureBile acid quantificationRepair responseBDF-1 miceDNA damageDose-dependent DNA damageEffects of exposureHistopathological studySubchronic exposureImmunohistochemical analysisLiver carcinogenLiver carcinogenicityLiver transcriptomicsDrinking waterMetabolomic profilingMicePotential mechanismsLiverEnvironmental chemicalsState maximum contaminant levelToxic effectsCell deathExposureOxidative stress responsePresent study
2020
Interplay between APC and ALDH1B1 in a newly developed mouse model of colorectal cancer
Golla JP, Kandyliari A, Tan WY, Chen Y, Orlicky DJ, Thompson DC, Shah YM, Vasiliou V. Interplay between APC and ALDH1B1 in a newly developed mouse model of colorectal cancer. Chemico-Biological Interactions 2020, 331: 109274. PMID: 33007288, PMCID: PMC9201852, DOI: 10.1016/j.cbi.2020.109274.Peer-Reviewed Original ResearchConceptsColorectal cancerColonic adenomasPresent preliminary studyMouse modelConsecutive daysLarge colonic adenomaPresence of adenomasApc mouse modelColon tumor growthMouse xenograft modelColon epithelial cellsFurther mechanistic studiesCancer mortalityKO miceLeading causeColorectal adenomasCRC developmentImmunohistochemical analysisXenograft modelTumor growthColorectal tumorigenesisAdenomasExpression scoreMale ApcMiceScience of superstimulation
Golla JP, Golla SK, Shelling AN. Science of superstimulation. Fertility And Sterility 2020, 114: 504-505. PMID: 32912611, DOI: 10.1016/j.fertnstert.2020.07.015.Peer-Reviewed Original ResearchAntiproliferative activity of protein hydrolysates derived from fish by-products on human colon and breast cancer cells.
Kandyliari A, Golla J, Chen Y, Papandroulakis N, Kapsokefalou M, Vasiliou V. Antiproliferative activity of protein hydrolysates derived from fish by-products on human colon and breast cancer cells. Proceedings Of The Nutrition Society 2020, 79: e282. DOI: 10.1017/s002966512000230x.Peer-Reviewed Original ResearchBreast cancer cellsCancer cellsColo320 cellsGrowth inhibitionAdenocarcinoma cellsHuman colonAntiproliferative activityHuman colorectal adenocarcinoma cellsColorectal adenocarcinoma cellsHuman breast adenocarcinoma cellsDietary guidelinesBreast adenocarcinoma cellsSignificant growth inhibitionWilcoxon Signed RanksHuman cancer cellsGilthead sea breamBeneficial effectsMean percentageConsumption of fishHealth benefitsSignificant antiproliferative activityStatistical significanceMTT assayCellular proliferationPreliminary dataNutrient Composition and Fatty Acid and Protein Profiles of Selected Fish By-Products
Kandyliari A, Mallouchos A, Papandroulakis N, Golla JP, Lam TT, Sakellari A, Karavoltsos S, Vasiliou V, Kapsokefalou M. Nutrient Composition and Fatty Acid and Protein Profiles of Selected Fish By-Products. Foods 2020, 9: 190. PMID: 32075005, PMCID: PMC7074476, DOI: 10.3390/foods9020190.Peer-Reviewed Original ResearchProtein profilesNicotinamide adenine dinucleotide dehydrogenaseSignificant protein sourceSubunit 8Fish speciesAbundant proteinsFatty acidsNutrient compositionSubunit epsilonFishFish samplesProcessing of fishProtein sourceNutritional valueNutritive contentEicosenoic acidValuable sourceAcidAquacultureSpeciesProteinDehydrogenaseGood sourceNutrientsEpsilon
2019
Integrated multi-omics approach reveals a role of ALDH1A1 in lipid metabolism in human colon cancer cells
Charkoftaki G, Thompson DC, Golla JP, Garcia-Milian R, Lam TT, Engel J, Vasiliou V. Integrated multi-omics approach reveals a role of ALDH1A1 in lipid metabolism in human colon cancer cells. Chemico-Biological Interactions 2019, 304: 88-96. PMID: 30851239, PMCID: PMC7988342, DOI: 10.1016/j.cbi.2019.02.030.Peer-Reviewed Original Research