Stiffening of the human proximal pulmonary artery with increasing age
Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.Peer-Reviewed Original ResearchConceptsProximal pulmonary arteriesPulmonary arteryAge-related stiffeningRight ventricular ejection fractionVentricular ejection fractionMean wall thicknessEjection fractionNo significant differenceSystemic circulationLuminal caliberDiffusing capacityArterial stiffeningIncreasing ageSignificant differenceDistensionArteryWall thicknessAdverse effectsWall strainVessel diameterCyclic biaxial strainOrgan donorsAgeMicrostructural remodelingRemodeling of Murine Branch Pulmonary Arteries Under Chronic Hypoxia and Short-Term Normoxic Recovery.
Ramachandra A, Jiang B, Jennings I, Manning E, Humphrey J. Remodeling of Murine Branch Pulmonary Arteries Under Chronic Hypoxia and Short-Term Normoxic Recovery. Journal Of Biomechanical Engineering 2024, 146 PMID: 38421341, DOI: 10.1115/1.4064967.Peer-Reviewed Original ResearchWeeks of hypoxiaBranch pulmonary arteriesWeeks of normoxic recoveryPulmonary arteryEndothelial cell responsesSmooth muscleChronic hypoxiaNormoxic recoveryPulmonary arterial remodelingCell responsesProximal pulmonary arteriesLongitudinal changesHypoxia-induced changesC57BL/6J micePulmonary pathologyThin collagen fibersArterial remodelingBiaxial mechanicsCircumferential stressEnergy storageNormal valuesHypoxiaWeeksVascular adaptationFraction of cytoplasmA Systematic Comparison of Normal Structure and Function of the Greater Thoracic Vessels
Ramachandra A, Cavinato C, Humphrey J. A Systematic Comparison of Normal Structure and Function of the Greater Thoracic Vessels. Annals Of Biomedical Engineering 2024, 52: 958-966. PMID: 38227167, DOI: 10.1007/s10439-023-03432-6.Peer-Reviewed Original ResearchThoracic vesselsVena cavaThoracic aortaCongenital heart surgeryRight pulmonary arterySuperior vena cavaInferior vena cavaRight subclavian arteryThoracic inferior vena cavaWild-type miceAscending thoracic aortaDescending thoracic aortaPulmonary arterySubclavian arteryHeart surgerySurgical interventionVasoactive responsesVenous circulationThoracicCavaNormal structureAortaArteryBiomechanical propertiesVascular system