2024
AT1b receptors contribute to regional disparities in angiotensin II mediated aortic remodelling in mice
Cavinato C, Spronck B, Caulk A, Murtada S, Humphrey J. AT1b receptors contribute to regional disparities in angiotensin II mediated aortic remodelling in mice. Journal Of The Royal Society Interface 2024, 21: 20240110. PMID: 39192727, PMCID: PMC11350382, DOI: 10.1098/rsif.2024.0110.Peer-Reviewed Original ResearchConceptsAngiotensin II infusionAT1B receptorsII infusionAngiotensin IIChronic angiotensin II infusionDays of angiotensin II infusionWild-typeAortas of WTSmooth muscle contractilityDescending thoracic aortaAngiotensin II signalingInflammatory cell responseRenin-angiotensin systemRegulating blood pressureAngII infusionAortic remodelingCell biological changesImmunohistological changesIndependent of sexMuscle contractilityMale miceMouse modelAbdominal aortaArterial remodelingBlood pressureMultiscale computational model of aortic remodeling following postnatal disruption of TGFβ signaling
Estrada A, Irons L, Tellides G, Humphrey J. Multiscale computational model of aortic remodeling following postnatal disruption of TGFβ signaling. Journal Of Biomechanics 2024, 169: 112152. PMID: 38763809, PMCID: PMC11141772, DOI: 10.1016/j.jbiomech.2024.112152.Peer-Reviewed Original ResearchAdult aortaTGFB signalingSmooth muscle cellsAortic remodelingCardiac-inducedMouse modelNormal mechanical loadingMuscle cellsPostnatal developmentHemodynamic loadNormal loadAortaMechanical homeostasisMechanical loadingMultiscale computational modelIncreasing loadLoadCell signalingGene productsStructural integrityCentral Artery Hemodynamics in Angiotensin II-Induced Hypertension and Effects of Anesthesia
Hopper S, Weiss D, Mikush N, Jiang B, Spronck B, Cavinato C, Humphrey J, Figueroa C. Central Artery Hemodynamics in Angiotensin II-Induced Hypertension and Effects of Anesthesia. Annals Of Biomedical Engineering 2024, 52: 1051-1066. PMID: 38383871, PMCID: PMC11418744, DOI: 10.1007/s10439-024-03440-0.Peer-Reviewed Original ResearchEffects of angiotensin II infusionMouse-to-mouse variationAngiotensin II-induced hypertensionRegional vascular structuresII-induced hypertensionAngiotensin II-infused miceAngiotensin II infusionWild-type miceDescending thoracic aortaGroups of miceSuprarenal abdominal aortaEffects of hypertensionCentral arterial stiffnessDepressed hemodynamicsII infusionIndicator of hypertensionSystemic hypertensionRenovascular diseaseCardiac functionInduced hypertensionDistal aortaThoracic aortaEffects of anesthesiaMouse modelAbdominal aorta
2019
Computational modeling predicts immuno-mechanical mechanisms of maladaptive aortic remodeling in hypertension
Latorre M, Bersi MR, Humphrey JD. Computational modeling predicts immuno-mechanical mechanisms of maladaptive aortic remodeling in hypertension. International Journal Of Engineering Science 2019, 141: 35-46. PMID: 32831391, PMCID: PMC7437922, DOI: 10.1016/j.ijengsci.2019.05.014.Peer-Reviewed Original ResearchAortic remodelingBlood pressure elevationCentral artery stiffnessMajor risk factorCommon mouse modelsBasic science studiesUncontrolled hypertensionIndicators of diseaseAortic stiffeningPressure elevationAdventitial fibrosisArtery stiffnessAortic growthRisk factorsAbdominal aortaCardiovascular diseaseMouse modelTherapeutic strategiesHypertensionAortic wallCompensatory increaseInflammationFibrosisDiseaseMarked increase
2017
Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms
Bellini C, Bersi MR, Caulk AW, Ferruzzi J, Milewicz DM, Ramirez F, Rifkin DB, Tellides G, Yanagisawa H, Humphrey JD. Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms. Journal Of The Royal Society Interface 2017, 14: 20161036. PMID: 28490606, PMCID: PMC5454287, DOI: 10.1098/rsif.2016.1036.Peer-Reviewed Original ResearchConceptsGenetic mutationsExtracellular matrix proteinsTransmembrane receptorsCytoskeletal proteinsMatrix proteinsWild-type controlsBiomechanical phenotypeDysfunctional mechanosensingExtracellular matrixDiverse mouse modelsSmooth muscle cellsMutationsMuscle cellsProteinAorta of miceMurine modelCellsMechanosensingElastic fiber integrityMouse modelMechanoregulationStructural integrityPhenotypeIntracellularIntegrity
2014
Myh 11 R 247 C / R 247 C mutations increase thoracic aorta vulnerability to intramural damage despite a general biomechanical adaptivity
Bellini C, Wang S, Milewicz DM, Humphrey JD. Myh 11 R 247 C / R 247 C mutations increase thoracic aorta vulnerability to intramural damage despite a general biomechanical adaptivity. Journal Of Biomechanics 2014, 48: 113-121. PMID: 25433566, PMCID: PMC4283495, DOI: 10.1016/j.jbiomech.2014.10.031.Peer-Reviewed Original ResearchConceptsThoracic aortaSevere vascular phenotypeAortic aneurysmContractile proteinsLocalized poolsMedial smooth muscle cellsEpigenetic factorsGenetic studiesThoracic aortic diseaseThoracic aortic aneurysmSmooth muscle cellsSuch mutationsMutationsC mutationAortic dissectionAortic diseaseHistopathologic characteristicsMuscle cellsRisk factorsGlycosaminoglycans/proteoglycansNormal adaptationMouse modelNormal biomechanicsAortic structureAorta