2019
Computational modeling predicts immuno-mechanical mechanisms of maladaptive aortic remodeling in hypertension
Latorre M, Bersi MR, Humphrey JD. Computational modeling predicts immuno-mechanical mechanisms of maladaptive aortic remodeling in hypertension. International Journal Of Engineering Science 2019, 141: 35-46. PMID: 32831391, PMCID: PMC7437922, DOI: 10.1016/j.ijengsci.2019.05.014.Peer-Reviewed Original ResearchAortic remodelingBlood pressure elevationCentral artery stiffnessMajor risk factorCommon mouse modelsBasic science studiesUncontrolled hypertensionIndicators of diseaseAortic stiffeningPressure elevationAdventitial fibrosisArtery stiffnessAortic growthRisk factorsAbdominal aortaCardiovascular diseaseMouse modelTherapeutic strategiesHypertensionAortic wallCompensatory increaseInflammationFibrosisDiseaseMarked increase
2016
Excessive Adventitial Remodeling Leads to Early Aortic Maladaptation in Angiotensin-Induced Hypertension
Bersi M, Bellini C, Wu J, Montaniel KR, Harrison DG, Humphrey JD. Excessive Adventitial Remodeling Leads to Early Aortic Maladaptation in Angiotensin-Induced Hypertension. Hypertension 2016, 67: 890-896. PMID: 27001298, PMCID: PMC4833633, DOI: 10.1161/hypertensionaha.115.06262.Peer-Reviewed Original ResearchConceptsAngiotensin II infusion modelAngiotensin-Induced HypertensionMost clinical assessmentsIntimal-medial thickeningWild-type miceNormal mechanical functionBlood pressureArterial stiffeningThoracic aortaInflammatory responseClinical assessmentEnd organsExuberant productionBlood flowCentral arteriesAdventitial collagenHypertensionWall stressExcessive accumulationInfusion modelMechanical functionWeeksCollagen resultsInflammationArtery