2024
Treating Migraine Patients With Cardiovascular Risks
Wang K, Sico J. Treating Migraine Patients With Cardiovascular Risks. Neurology 2024, 103: e210196. PMID: 39621947, DOI: 10.1212/wnl.0000000000210196.Peer-Reviewed Original ResearchNonaspirin nonsteroidal anti-inflammatory drugsCardiovascular safety profileSafety profileCardiovascular eventsCardiovascular riskIncreased riskIncreased risk of ischemic eventsRisk of ischemic eventsNonsteroidal anti-inflammatory drugsExclusion of patientsAdverse cardiovascular eventsMyocardial infractionRisk of acute cardiovascular eventsEffective acute treatmentTreat migraine patientsRisk of myocardial infractionCOX-2 inhibitorsAnti-inflammatory drugsAcute cardiovascular eventsMigraine patientsAcute treatmentIschemic eventsManaging cardiovascular riskRandomized trialsCOX-2After the Stroke (Secondary Prevention)
Bottomley S, Picagli J, Sico J. After the Stroke (Secondary Prevention). 2024, 445-457. DOI: 10.1007/978-3-031-66289-8_37.Peer-Reviewed Original ResearchThe Interdisciplinary Stroke Team
Bottomley S, Sico J. The Interdisciplinary Stroke Team. 2024, 417-430. DOI: 10.1007/978-3-031-66289-8_35.Peer-Reviewed Original Research2023 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline for the Management of Headache.
Sico J, Antonovich N, Ballard-Hernandez J, Buelt A, Grinberg A, Macedo F, Pace I, Reston J, Sall J, Sandbrink F, Skop K, Stark T, Vogsland R, Wayman L, Ford A. 2023 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline for the Management of Headache. Annals Of Internal Medicine 2024 PMID: 39467289, DOI: 10.7326/annals-24-00551.Peer-Reviewed Original ResearchClinical practice guidelinesU.S. Department of Veterans AffairsTension-type headacheDepartment of Veterans AffairsVeterans AffairsManagement of headacheCalcitonin gene-related peptidePractice guidelinesEpisodic migraineDefense Clinical Practice GuidelinesPrimary care cliniciansManagement of tension-type headacheRevised CPGTreatment of tension-type headacheDepartment of Defense Clinical Practice GuidelinesChronic tension-type headacheCalcitonin gene-related peptide monoclonal antibodiesTreatment of acute migrainePrevention of chronic migraineAerobic exerciseCare cliniciansPreventing episodic migrainePhysical therapyNonpharmacological interventionsSecondary headache disordersCharacteristics of men and women with medically diagnosed cluster headache in a national integrated healthcare system: A Veterans Health Administration cohort study
Seng E, Burish M, Fenton B, Schindler E, Zhou B, Phadke M, Skanderson M, Best R, Lipton R, Sico J. Characteristics of men and women with medically diagnosed cluster headache in a national integrated healthcare system: A Veterans Health Administration cohort study. Headache The Journal Of Head And Face Pain 2024, 64: 1273-1284. PMID: 39400858, DOI: 10.1111/head.14842.Peer-Reviewed Original ResearchVeterans Health AdministrationElectronic health recordsEHR dataHealthcare systemInternational Classification of Diseases (ICD)-9Integrated healthcare systemNational integrated healthcare systemFiscal yearHospital-based systemClinic-based studyProportion of womenCompared to menLongitudinal cohort of patientsIndividual medical recordsRates of suicidal ideationCH diagnosisStratified prevalenceHealth recordsTobacco useMental healthHealth AdministrationPain diagnosisInternational ClassificationPeriod prevalenceOutpatient visitsComparison of clinical pharmacist practitioners’ headache care roles across clinical contexts within the Veterans Health Administration: Optimizing pharmacist integration
Goldman R, Damush T, Guirguis A, Datre O, Baird S, Sico J. Comparison of clinical pharmacist practitioners’ headache care roles across clinical contexts within the Veterans Health Administration: Optimizing pharmacist integration. Headache The Journal Of Head And Face Pain 2024 PMID: 39269026, DOI: 10.1111/head.14834.Peer-Reviewed Original ResearchVeterans Health AdministrationClinical pharmacist practitionersVHA facilitiesHeadache careCare teamEnhance patient outcomesPharmacist practitionersSpecialist servicesHealth AdministrationPracticing pharmacistsQualitative studyCross-sectional qualitative studyAdvanced practice pharmacistBehavior change skillsPatient outcomesSpecialty care servicesNon-formulary medicationsReading of transcriptsPharmacist integrationPrimary carePain teamCaring roleCare servicesHeadache neurologistPhysician educationOpen Burn Pit Exposure in Headache Disorder and Migraine
Sico J, Anthony S, Phadke M, Wang K, Skanderson M, Ney J, Seng E, Shapiro R, Sandbrink F, Scholten J, Graham G, Martini S, Fenton B. Open Burn Pit Exposure in Headache Disorder and Migraine. JAMA Network Open 2024, 7: e2431522. PMID: 39230902, PMCID: PMC11375476, DOI: 10.1001/jamanetworkopen.2024.31522.Peer-Reviewed Original ResearchConceptsBurn pit exposureVeterans Health Administration electronic health recordPit exposureHeadache disordersAdministration electronic health recordAnalytic sampleVeterans Health Administration facilitiesBurn pitsCohort studyVeterans Health AdministrationElectronic health recordsDose-dependent associationUS DepartmentHealth recordsRegistry participantsMilitary exposuresRetrospective cohort studyHealth AdministrationMain OutcomesHealth conditionsAdministration facilitiesRegistry questionnaireHighest quartilesIncident outcomesVeteransHeadache Specialists’ Perceptions of the Role of Health Psychologists in Headache Management: A Qualitative Study
Takagishi S, Grinberg A, Lindsey H, Goldman R, Baird S, Burrone L, Sico J, Damush T. Headache Specialists’ Perceptions of the Role of Health Psychologists in Headache Management: A Qualitative Study. Cureus 2024, 16: e56175. PMID: 38618328, PMCID: PMC11015910, DOI: 10.7759/cureus.56175.Peer-Reviewed Original ResearchPrescription Drug Prices: An AAN Position Statement.
Santoro J, Sico J, Burke J, Sarkar K, Turbes M, Evans D, Jordan J. Prescription Drug Prices: An AAN Position Statement. Neurology 2024, 102: e209132. PMID: 38335469, DOI: 10.1212/wnl.0000000000209132.Peer-Reviewed Original ResearchConceptsHigh cost of medicationNeurological disordersDevelopment of novel therapeuticsNeurological diseasesOrphan Drug ActTherapeutic optionsCost of medicationsHigh-value careCost of prescription drugsPrescription drug pricesRare diseaseTreat rare diseasesPatientsNovel therapeuticsTreat neurological disordersDrug ActCost containment effortsChronic neurological conditionsEffective prescription medicationsMedicationPrescriber accessPrescription medicationsTherapyHealthcare systemApproval pathwayReal-world analysis of two ischaemic stroke and TIA systolic blood pressure goals on 12-month mortality and recurrent vascular events
Sico J, Hu X, Myers L, Levine D, Bravata D, Arling G. Real-world analysis of two ischaemic stroke and TIA systolic blood pressure goals on 12-month mortality and recurrent vascular events. Stroke And Vascular Neurology 2024, 9: svn-2023-002759. PMID: 38191185, DOI: 10.1136/svn-2023-002759.Peer-Reviewed Original ResearchTransient ischemic attackSystolic blood pressureVeterans Administration Medical CenterStroke/transient ischemic attackIntensive SBP goalRecurrent vascular eventsCardiovascular eventsVascular eventsSBP goalSBP groupRecurrent stroke/transient ischemic attackMultivariable Cox proportional hazards regressionGoal systolic blood pressureIndex emergency department visitStroke/TIA patientsSystolic blood pressure goalAverage systolic blood pressureLower systolic blood pressureCox proportional hazards regressionBlood pressure goalsRecurrent cerebrovascular eventsRetrospective cohort studyEmergency department visitsProportional hazards regressionSignificant higher riskChronic headaches after traumatic brain injury: Diagnostic complexity associated with increased cost.
McGeary D, Swan A, Kennedy E, Dismuke-Greer C, McGeary C, Sico J, Amuan M, Manhapra A, Bouldin E, Watson P, Kenney K, Myers M, Werner J, Mitchell J, Carlson K, Delgado R, Esmaeili A, Pugh M. Chronic headaches after traumatic brain injury: Diagnostic complexity associated with increased cost. Neurorehabilitation 2024, 55: 303-317. PMID: 39422976, DOI: 10.3233/nre-230277.Peer-Reviewed Original ResearchTraumatic brain injuryChronic headacheTraumatic brain injury diagnosisPost-9/11-era veteransPost-traumatic headacheAssociated with higher costsCare burdenBrain injuryHealthcare costsHeadache diagnosisEra veteransClinical characteristicsHeadache disordersHigher expendituresCareVeteransIndividual headachesHigh costHeadacheIntensive treatmentRefractory headacheOutcomesDiagnosisInjuryConfounding
2023
Studying classic psychedelics for the management of headache disorders: Considerations for Veterans
Schindler E, Sico J. Studying classic psychedelics for the management of headache disorders: Considerations for Veterans. Journal Of Military Veteran And Family Health 2023, 9: 88-95. DOI: 10.3138/jmvfh-2023-0006.Peer-Reviewed Original ResearchHeadache disordersCluster headacheLysergic acid diethylamideTreatment optionsBrain injuryTherapeutic effectAcid diethylamideTraumatic brain injuryConventional treatment optionsTrials of psilocybinMilitary membersPoor qualityPsychedelic drugsSummary PatientsHead traumaAvailable treatmentsHeadache managementHeadache treatmentCommon conditionHigh riskSide effectsSignificant disabilityHeadacheMore researchPoor efficacyCommon Pathways of Epileptogenesis in Patients With Epilepsy Post–Brain Injury
Misra S, Khan E, Lam T, Mazumder R, Gururangan K, Hickman L, Goswami V, Funaro M, Eldem E, Sansing L, Sico J, Quinn T, Liebeskind D, Montaner J, Kwan P, Mishra N. Common Pathways of Epileptogenesis in Patients With Epilepsy Post–Brain Injury. Neurology 2023, 101: e2243-e2256. PMID: 37550071, PMCID: PMC10727219, DOI: 10.1212/wnl.0000000000207749.Peer-Reviewed Original ResearchConceptsStandardized mean differencePoststroke epilepsyBrain injuryGenetic susceptibilityDisparate time pointsRisk of epileptogenesisLate-onset seizuresDevelopment of epilepsyBlood glucose levelsTraumatic brain injuryMean biomarker levelsIndividual genetic susceptibilityWeb of ScienceReported biomarkersPrimary outcomeEpileptogenic processBiofluid biomarkersBias assessmentBiomarker levelsCommon biological pathwaysEnrichment analysisGlucose levelsHigh riskPrognostic studiesEpilepsyThe Headache Psychologists’ Role in Pediatric and Adult Headache Care: A Qualitative Study of Expert Practitioners
Grinberg A, Damush T, Lindsey H, Burrone L, Baird S, Takagishi S, Snyder I, Goldman R, Sico J, Seng E. The Headache Psychologists’ Role in Pediatric and Adult Headache Care: A Qualitative Study of Expert Practitioners. Journal Of Clinical Psychology In Medical Settings 2023, 31: 359-367. PMID: 37839060, PMCID: PMC11102355, DOI: 10.1007/s10880-023-09972-2.Peer-Reviewed Original ResearchBehavioral treatmentBehavioral interventionsTreatment contentCognitive behavioral therapyEvidence-based behavioral interventionsEvidence-based behavior change interventionsBehavioral therapyBehaviour change interventionsRelaxation trainingPsychologistsSemi-structured interviewsHeadache activityStandalone optionChange interventionsHeadache careOpen-ended questionsParticipantsStandalone treatmentHeadache disordersBrief durationHeadache treatmentExpert practitionersMedical settingsPurposive sampleSuccessful referralChanges in opioid prescribing in veterans with headache during the COVID‐19 pandemic: A regression discontinuity in time analysis
Wang K, Fenton B, Skanderson M, Black A, Becker W, Seng E, Anthony S, Guirguis A, Altalib H, Kimber A, Lorenze N, Scholten J, Graham G, Sandbrink F, Sico J. Changes in opioid prescribing in veterans with headache during the COVID‐19 pandemic: A regression discontinuity in time analysis. Headache The Journal Of Head And Face Pain 2023, 63: 1295-1303. PMID: 37596904, DOI: 10.1111/head.14605.Peer-Reviewed Original ResearchMorphine equivalent daily dosesVeterans Health AdministrationNumber of prescriptionsOpioid prescribingOpioid prescriptionsLong-term opioid therapyMME/dayRetrospective cohort studyEquivalent daily dosesCOVID-19 pandemicOpioid therapyPre-pandemic periodCohort studyDaily doseChronic painOutpatient visitsPrevious diagnosisDaily dosesMean ageSubgroup analysisHeadache disordersOpioid accessHealth AdministrationPrescribingCoronavirus diseaseTrajectory of blood pressure after initiating anti-calcitonin gene-related peptide treatment of migraine: a target trial emulation from the veterans health administration
Wang K, Fenton B, Dao V, Guirguis A, Anthony S, Skanderson M, Sico J. Trajectory of blood pressure after initiating anti-calcitonin gene-related peptide treatment of migraine: a target trial emulation from the veterans health administration. The Journal Of Headache And Pain 2023, 24: 108. PMID: 37582724, PMCID: PMC10426172, DOI: 10.1186/s10194-023-01640-y.Peer-Reviewed Original ResearchConceptsAnti-CGRP treatmentVeterans Health AdministrationBlood pressureBP changesHealth AdministrationDiastolic BP changesExacerbation of hypertensionNumber of antihypertensivesIncidence of hypertensionHigher healthcare utilizationSystolic BP changeKaplan-Meier curvesBlood pressure readingsGene-related peptideTarget trial emulationYears of treatmentBlood pressure regulationHigh-quality real-world evidenceReal-world evidenceMixed-effects Poisson modelsChronic migraine diagnosisInverse probability weightsAntihypertension medicationsAntihypertensive medicationsBaseline hypertensionLongitudinal Care Patterns and Utilization Among Patients With New-Onset Neck Pain by Initial Provider Specialty
Fenton J, Fang S, Ray M, Kennedy J, Padilla K, Amundson R, Elton D, Haldeman S, Lisi A, Sico J, Wayne P, Romano P. Longitudinal Care Patterns and Utilization Among Patients With New-Onset Neck Pain by Initial Provider Specialty. Spine 2023, 48: 1409-1418. PMID: 37526092, DOI: 10.1097/brs.0000000000004781.Peer-Reviewed Original ResearchConceptsNeck painProvider specialtyTherapeutic interventionsCare patternsPain visitsInitial visitOptum Labs Data WarehouseDiagnostic imagingAcute back painAcute neck painPlurality of patientsRetrospective cohort studyElectronic health record dataLarge national cohortInvasive therapeutic interventionsHealth record dataCohort studyMajor surgeryBack painOutpatient visitsNational cohortPrimary careTherapeutic injectionsEmergency physiciansBACKGROUND DATADevelopment and validation of a model predicting mild stroke severity on admission using electronic health record data
Waddell K, Myers L, Perkins A, Sico J, Sexson A, Burrone L, Taylor S, Koo B, Daggy J, Bravata D. Development and validation of a model predicting mild stroke severity on admission using electronic health record data. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107255. PMID: 37473533, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107255.Peer-Reviewed Original ResearchConceptsInitial stroke severityStroke severityElectronic health record dataHealth record dataSevere strokeIschemic strokeStroke careSample patientsMortality risk stratificationRecord dataVeterans Affairs hospitalMild stroke severityMultiple logistic regressionObservational cohortStroke outcomeIndependent predictorsRisk stratificationEHR data elementsPrimary analysisLogistic regressionStrokeValidation sampleSeverityPotent modifierEHR dataCalcitonin Gene–Related Peptide Monoclonal Antibodies and Risk of SARS-CoV-2 Infection and Severe COVID-19 Outcomes Among Veterans With Migraine Disorder
Wang K, Fenton B, Deng Y, Anthony S, Dao V, Schindler E, Lipton R, Guirguis A, Skanderson M, Seng E, Sico J. Calcitonin Gene–Related Peptide Monoclonal Antibodies and Risk of SARS-CoV-2 Infection and Severe COVID-19 Outcomes Among Veterans With Migraine Disorder. JAMA Network Open 2023, 6: e2326371. PMID: 37523183, PMCID: PMC10391301, DOI: 10.1001/jamanetworkopen.2023.26371.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptideSARS-CoV-2 infectionSevere COVID-19 outcomesCGRP mAbsMechanical ventilationSupplemental oxygenCOVID-19 outcomesSARS-CoV-2Cohort studyCGRP antagonistMAIN OUTCOMEMigraine disordersPositive SARS-CoV-2 test resultSARS-CoV-2 test resultsCOVID-19Protocol hazard ratiosRetrospective cohort studyMonoclonal antibody treatmentGene-related peptideLikelihood of hospitalizationCourse of diseasePeptide monoclonal antibodyElectronic health recordsNeuroimmune modulatorCumulative incidenceMigraine screening in English and Spanish
Lipton R, Sico J, Seng E. Migraine screening in English and Spanish. Headache The Journal Of Head And Face Pain 2023, 63: 843-845. PMID: 37140197, DOI: 10.1111/head.14520.Peer-Reviewed Original Research