2023
Trajectory of blood pressure after initiating anti-calcitonin gene-related peptide treatment of migraine: a target trial emulation from the veterans health administration
Wang K, Fenton B, Dao V, Guirguis A, Anthony S, Skanderson M, Sico J. Trajectory of blood pressure after initiating anti-calcitonin gene-related peptide treatment of migraine: a target trial emulation from the veterans health administration. The Journal Of Headache And Pain 2023, 24: 108. PMID: 37582724, PMCID: PMC10426172, DOI: 10.1186/s10194-023-01640-y.Peer-Reviewed Original ResearchConceptsAnti-CGRP treatmentVeterans Health AdministrationBlood pressureBP changesHealth AdministrationDiastolic BP changesExacerbation of hypertensionNumber of antihypertensivesIncidence of hypertensionHigher healthcare utilizationSystolic BP changeKaplan-Meier curvesBlood pressure readingsGene-related peptideTarget trial emulationYears of treatmentBlood pressure regulationHigh-quality real-world evidenceReal-world evidenceMixed-effects Poisson modelsChronic migraine diagnosisInverse probability weightsAntihypertension medicationsAntihypertensive medicationsBaseline hypertension
2022
Blood Pressure Trajectories and Outcomes for Veterans Presenting at VA Medical Centers with a Stroke or Transient Ischemic Attack
Arling G, Perkins A, Myers LJ, Sico JJ, Bravata DM. Blood Pressure Trajectories and Outcomes for Veterans Presenting at VA Medical Centers with a Stroke or Transient Ischemic Attack. The American Journal Of Medicine 2022, 135: 889-896.e1. PMID: 35292287, DOI: 10.1016/j.amjmed.2022.02.012.Peer-Reviewed Original ResearchConceptsSystolic blood pressure trajectoriesTransient ischemic attackSystolic blood pressureBlood pressure trajectoriesBlood pressureAntihypertensive medicationsIschemic attackPressure trajectoriesHigher systolic blood pressureLower systolic blood pressureCox proportional hazards modelBlood pressure reductionBlood pressure controlEmergency department visitsHazard of mortalityProportional hazards modelVA Medical CenterMedication intensificationCause mortalityVascular eventsIschemic strokeRetrospective cohortDepartment visitsHypertension managementIndex event
2012
Diagnosis and Treatment of Sleep Apnea in patients' homes: the rationale and methods of the "GoToSleep" randomized-controlled trial.
Bravata DM, Ferguson J, Miech EJ, Agarwal R, McClain V, Austin C, Struve F, Foresman B, Li X, Wang Z, Williams LS, Dallas MI, Couch CD, Sico J, Fragoso C, Matthias MS, Chumbler N, Myers J, Burrus N, Dube A, French DD, Schmid AA, Concato J, Yaggi HK. Diagnosis and Treatment of Sleep Apnea in patients' homes: the rationale and methods of the "GoToSleep" randomized-controlled trial. Journal Of Clinical Sleep Medicine 2012, 8: 27-35. PMID: 22334806, PMCID: PMC3266333, DOI: 10.5664/jcsm.1654.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureAuto-titrating continuous positive airway pressureTransient ischemic attackSleep apneaVeterans Health AdministrationCerebrovascular diseaseControl groupAntihypertensive medicationsIntervention groupPatient's homePressure continuous positive airway pressureUsual care control groupControl of hypertensionPositive airway pressureCare control groupLaboratory-based sleep studiesUndiagnosed sleep apneaBlood pressure assessmentInclusion of patientsRandomized-controlled trialBlood pressure measurementsHome-based polysomnographySleep laboratory polysomnographyOne-year study periodTherapeutic intervention strategies