2017
Single-chromosome Gains Commonly Function as Tumor Suppressors
Sheltzer J, Ko J, Replogle J, Burgos N, Chung E, Meehl C, Sayles N, Passerini V, Storchova Z, Amon A. Single-chromosome Gains Commonly Function as Tumor Suppressors. Cancer Cell 2017, 31: 240-255. PMID: 28089890, PMCID: PMC5713901, DOI: 10.1016/j.ccell.2016.12.004.Peer-Reviewed Original ResearchConceptsSingle chromosome gainsSingle extra chromosomeEffects of aneuploidyHallmarks of cancerEvolutionary flexibilityFitness defectsEuploid cellsTumor suppressorExtra chromosomeEuploid counterpartsOncogenic pathwaysProlonged growthChromosomal alterationsCancer developmentCell linesTrisomic cellsImproved fitnessAneuploidyTrisomic cell lineCellsChromosomesSuppressorAdditional chromosomal alterationsGrowthTumorigenesis
2011
The aneuploidy paradox: costs and benefits of an incorrect karyotype
Sheltzer J, Amon A. The aneuploidy paradox: costs and benefits of an incorrect karyotype. Trends In Genetics 2011, 27: 446-453. PMID: 21872963, PMCID: PMC3197822, DOI: 10.1016/j.tig.2011.07.003.Peer-Reviewed Original ResearchConceptsCell proliferationRole of aneuploidyHallmarks of cancerExperimental evolutionEnhanced proliferative capacityCellular phenotypesChromosomal instabilityAneuploid cellsNormal cellsKaryotypic imbalancesProliferative capacityAneuploidyDiverse effectsProliferationCellsPhenotypeMicroorganismsKaryotypeHallmark