2013
A Transcriptional and Metabolic Signature of Primary Aneuploidy Is Present in Chromosomally Unstable Cancer Cells and Informs Clinical Prognosis
Sheltzer J. A Transcriptional and Metabolic Signature of Primary Aneuploidy Is Present in Chromosomally Unstable Cancer Cells and Informs Clinical Prognosis. Cancer Research 2013, 73: 6401-6412. PMID: 24041940, PMCID: PMC3901577, DOI: 10.1158/0008-5472.can-13-0749.Peer-Reviewed Original ResearchConceptsChromosomal instabilityPrimary cellsUnstable cancer cellsAneuploid cellsSubset of genesProliferation-independent mannerHigh mitotic activityCancer cell linesAggressive diseasePoor prognosisClinical prognosisTypes of aneuploidyPrimary aneuploidyCellular stressAbnormal karyotypeTranscriptional alterationsHuman patientsTCA cycle fluxCancerMetabolic signaturesAneuploid cancersTranscriptional signatureCancer cellsCancer linesMitotic activity
2012
Transcriptional consequences of aneuploidy
Sheltzer J, Torres E, Dunham M, Amon A. Transcriptional consequences of aneuploidy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 12644-12649. PMID: 22802626, PMCID: PMC3411958, DOI: 10.1073/pnas.1209227109.Peer-Reviewed Original ResearchConceptsConsequences of aneuploidyRelated gene expression patternsAneuploid cellsSimilar cellular pathwaysGene expression patternsGene expression dataDiverse organismsDifferent organismsTranscriptional consequencesDifferent chromosomesCell physiologyCellular pathwaysExpression patternsGene expressionCell cycleExpression dataDifferent aneuploidiesAntiproliferative responseCell proliferationGenesOrganismsSpeciesAneuploidySpecific chromosomal aberrationsChromosomal aberrations
2011
The aneuploidy paradox: costs and benefits of an incorrect karyotype
Sheltzer J, Amon A. The aneuploidy paradox: costs and benefits of an incorrect karyotype. Trends In Genetics 2011, 27: 446-453. PMID: 21872963, PMCID: PMC3197822, DOI: 10.1016/j.tig.2011.07.003.Peer-Reviewed Original ResearchConceptsCell proliferationRole of aneuploidyHallmarks of cancerExperimental evolutionEnhanced proliferative capacityCellular phenotypesChromosomal instabilityAneuploid cellsNormal cellsKaryotypic imbalancesProliferative capacityAneuploidyDiverse effectsProliferationCellsPhenotypeMicroorganismsKaryotypeHallmark