2024
Urine Biomarkers for Diabetic Kidney Disease Progression
Schrauben S, Ix J, Shlipak M, Dobre M, Gutierrez O, Sarnak M, Ricardo A, Coca S, Greenberg J, Waikar S, Parikh C, Cohen D, Hsu C, Taliercio J, Schelling J, Rao P, Kimmel P, Bonventre J. Urine Biomarkers for Diabetic Kidney Disease Progression. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.202430q60j6p. DOI: 10.1681/asn.202430q60j6p.Peer-Reviewed Original ResearchDefining Kidney Health Dimensions and Their Associations with Adverse Outcomes in Persons with Diabetes and CKD
Peschard V, Scherzer R, Katz R, Sarnak M, Ascher S, Lash J, Schrauben S, Parikh C, Ilori T, Kimmel P, Coca S, Gutierrez O, Ramachandran V, Sondheimer J, Cheung K, Bonventre J, Levitan E, Schelling J, Taliercio J, Rao P, Greenberg J, Chen J, Estrella M, Ix J, Shlipak M. Defining Kidney Health Dimensions and Their Associations with Adverse Outcomes in Persons with Diabetes and CKD. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024fkhmb714. DOI: 10.1681/asn.2024fkhmb714.Peer-Reviewed Original ResearchAdverse Long-Term Outcomes following AKI in Hospitalized Children: A Meta-Analysis
Meena J, Ali S, Kamran D, Sabeeh D, Ajoy H, Greenberg J, Robinson C, Yadav J, Chanchlani R. Adverse Long-Term Outcomes following AKI in Hospitalized Children: A Meta-Analysis. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024ta54spsj. DOI: 10.1681/asn.2024ta54spsj.Peer-Reviewed Original ResearchLong-Term Kidney Outcomes after Pediatric Acute Kidney Injury
Robinson C, Jeyakumar N, Luo B, Askenazi D, Deep A, Garg A, Goldstein S, Greenberg J, Mammen C, Nash D, Parekh R, Silver S, Thabane L, Wald R, Zappitelli M, Chanchlani R. Long-Term Kidney Outcomes after Pediatric Acute Kidney Injury. Journal Of The American Society Of Nephrology 2024, 35: 1520-1532. PMID: 39018120, PMCID: PMC11543010, DOI: 10.1681/asn.0000000000000445.Peer-Reviewed Original ResearchAcute kidney replacement therapyAcute kidney injuryKidney replacement therapyLong-term kidney replacement therapyChronic kidney diseasePediatric acute kidney injuryHospital CompareAcute kidney injury survivorsKidney injuryProvincial administrative health databasesLong-term chronic kidney diseaseLong-term risk of chronic kidney diseaseLong-term kidney outcomesMajor Adverse Kidney EventsHospitalized childrenAdministrative health databasesRisk of chronic kidney diseaseIntensive care unit admissionIncident chronic kidney diseaseAdverse kidney eventsRetrospective cohort studyPediatric AKI survivorsLong-term riskNeonatal statusPropensity score matchingUrine Biomarkers of Kidney Tubule Health and Risk of Incident CKD in Persons Without Diabetes: The ARIC, MESA, and REGARDS Studies
Amatruda J, Katz R, Rebholz C, Sarnak M, Gutierrez O, Schrauben S, Greenberg J, Coresh J, Cushman M, Waikar S, Parikh C, Schelling J, Jogalekar M, Bonventre J, Vasan R, Kimmel P, Ix J, Shlipak M, Consortium C. Urine Biomarkers of Kidney Tubule Health and Risk of Incident CKD in Persons Without Diabetes: The ARIC, MESA, and REGARDS Studies. Kidney Medicine 2024, 6: 100834. PMID: 38826568, PMCID: PMC11141432, DOI: 10.1016/j.xkme.2024.100834.Peer-Reviewed Original ResearchAssociated with incident chronic kidney diseaseIncident chronic kidney diseaseChronic kidney diseaseUrine MCP-1Meta-analysisUrine biomarkersMCP-1A1M concentrationsMultivariable Cox proportional hazards regressionRisk of chronic kidney diseaseRisk of incident chronic kidney diseaseCox proportional hazards regressionIndependent of eGFRPrevalent chronic kidney diseaseCohort of adultsMeta-analysis of resultsA1MLong follow-up periodEarly chronic kidney diseaseFollow-up periodProportional hazards regressionUrine A1MARIC participantsREGARDS studyHealth markersIs mild dehydration a risk for progression of childhood chronic kidney disease?
Le Page A, Johnson E, Greenberg J. Is mild dehydration a risk for progression of childhood chronic kidney disease? Pediatric Nephrology 2024, 39: 3177-3191. PMID: 38632124, PMCID: PMC11413076, DOI: 10.1007/s00467-024-06332-6.Peer-Reviewed Original ResearchChronic kidney diseaseChronic kidney disease aetiologyKidney diseaseGraphical abstractA higher resolution versionMild dehydrationRisk of CKD progressionConcentrating capacityChronic kidney disease populationFrequency of dehydrationChildhood chronic kidney diseaseImpact renal functionRisk of complicationsLow fluid intakeAssessment of dehydrationChronic kidney disease outcomesHyperfiltration injuryRandomised controlled trialsArginine vasopressinRenal functionCKD progressionFluid intakeTreatment planningAdequate hydrationRisk factorsControlled trialsCOVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes
Aklilu A, Kumar S, Nugent J, Yamamoto Y, Coronel-Moreno C, Kadhim B, Faulkner S, O’Connor K, Yasmin F, Greenberg J, Moledina D, Testani J, Wilson F. COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes. JAMA Internal Medicine 2024, 184: 414-423. PMID: 38407862, PMCID: PMC10897825, DOI: 10.1001/jamainternmed.2023.8225.Peer-Reviewed Original ResearchCOVID-19-associated acute kidney injuryCOVID-19-associated AKIAcute kidney injuryMulticenter cohort studyKidney function declineKidney functionKidney injuryCohort studyKidney outcomes of patientsIncidence of acute kidney injuryLong-term kidney outcomesHistorical cohort of patientsMultivariate time-to-event analysesPositive influenza ALongitudinal multicenter cohort studyWorsening kidney functionOutcomes of patientsAdverse kidney eventsCohort of patientsComposite of mortalityMarkers of illness severityAdult hospitalized patientsBaseline comorbidity scoreTime-to-event analysisFunctional decline
2023
Urine Proteomic Profiling and Insights into CKD Progression in Children
Greenberg J, Lee A, Coresh J, Warady B, Ix J, Furth S, Denburg M. Urine Proteomic Profiling and Insights into CKD Progression in Children. Journal Of The American Society Of Nephrology 2023, 34: 823-823. DOI: 10.1681/asn.20233411s1823b.Peer-Reviewed Original ResearchDecoding the Association Between Body Composition in Preterm Birth and Hypertension in Childhood—Reply
Nugent J, Sharifi M, Greenberg J. Decoding the Association Between Body Composition in Preterm Birth and Hypertension in Childhood—Reply. JAMA Pediatrics 2023, 177: 1239-1240. PMID: 37695615, DOI: 10.1001/jamapediatrics.2023.3519.Peer-Reviewed Original ResearchLong-Term Outcomes After Pediatric Non-Dialysis-Treated AKI: A Population-Based Cohort Study
Robinson C, Jeyakumar N, Askenazi D, Deep A, Garg A, Goldstein S, Greenberg J, Mammen C, Nash D, Parekh R, Silver S, Wald R, Zappitelli M, Chanchlani R. Long-Term Outcomes After Pediatric Non-Dialysis-Treated AKI: A Population-Based Cohort Study. Journal Of The American Society Of Nephrology 2023, 34: 232-232. DOI: 10.1681/asn.20233411s1232a.Peer-Reviewed Original ResearchRecent ambient temperature and fine particulate matter (PM2.5) exposure is associated with urinary kidney injury biomarkers in children
Politis M, Gutiérrez-Avila I, Just A, Pizano-Zárate M, Tamayo-Ortiz M, Greenberg J, Téllez-Rojo M, Sanders A, Rosa M. Recent ambient temperature and fine particulate matter (PM2.5) exposure is associated with urinary kidney injury biomarkers in children. The Science Of The Total Environment 2023, 907: 168119. PMID: 37884142, PMCID: PMC10842020, DOI: 10.1016/j.scitotenv.2023.168119.Peer-Reviewed Original ResearchConceptsDistributed lag nonlinear modelParticulate matterAverage PM<sub>2.5</sub>Satellite-based spatio-temporal modelUrinary kidney injury biomarkersFine particulate matterExposure to ambient temperatureAir pollutionAerodynamic diameterBirth cohort studySpatio-temporal modelParticipating residentsCohort studyLimited researchEnvironmental exposuresMean temperatureDaily mean temperatureVisitsDaily temperatureAmbient temperatureMatterExposurePM2.5Linear regressionPollutionAssociations of Exposure to Urinary Metals with Kidney Injury Biomarkers among Pre-adolescent Children: A Cross-Sectional Study
Politis M, Yao M, Gennings C, Ortiz M, Amarasiriwardena C, Pantic I, Tolentino M, Gutierrez G, Greenberg J, Rojo M, Sanders A, Rosa M. Associations of Exposure to Urinary Metals with Kidney Injury Biomarkers among Pre-adolescent Children: A Cross-Sectional Study. ISEE Conference Abstracts 2023, 2023 DOI: 10.1289/isee.2023.vo-032.Peer-Reviewed Original ResearchEffect Measure Modification by Birth Weight on the Association Between Overweight or Obesity and Hypertension in Children and Adolescents
Nugent J, Lu Y, Deng Y, Sharifi M, Greenberg J. Effect Measure Modification by Birth Weight on the Association Between Overweight or Obesity and Hypertension in Children and Adolescents. JAMA Pediatrics 2023, 177: 735-737. PMID: 37155182, PMCID: PMC10167596, DOI: 10.1001/jamapediatrics.2023.0799.Peer-Reviewed Original ResearchAssociations of Biomarkers of Kidney Tubule Health, Injury, and Inflammation with Left Ventricular Hypertrophy in Children with CKD
Jiang K, Greenberg J, Abraham A, Xu Y, Schelling J, Feldman H, Schrauben S, Waikar S, Shlipak M, Wettersten N, Coca S, Vasan R, Gutierrez O, Ix J, Warady B, Kimmel P, Bonventre J, Parikh C, Mitsnefes M, Denburg M, Furth S, Ramachandran V, Schelling J, Denburg M, Furth S, Warady B, Bonventre J, Waikar S, Sabbisetti V, Coresh J, Grams M, Rebholz C, Abraham A, Parikh C, Coca S, Rhee E, Kimmel P, Kusek J, Rovin B, Shlipak M, Sarnak M, Gutiérrez O, Ix J, Dubin R, Hostetter T, Deo R, Feldman H, Xie D, Shou H, Ballard S, Whitehead K, Collins H, Greenberg J, Ganz P. Associations of Biomarkers of Kidney Tubule Health, Injury, and Inflammation with Left Ventricular Hypertrophy in Children with CKD. Kidney360 2023, 4: 1039-1047. PMID: 37303083, PMCID: PMC10476681, DOI: 10.34067/kid.0000000000000183.Peer-Reviewed Original ResearchConceptsKidney injury molecule-1Left ventricular hypertrophyUrine KIM-1Injury molecule-1Chemoattractant protein-1Ventricular hypertrophyAlpha-1-microglobulinHigher plasmaLVH prevalenceHigh prevalenceMolecule-1Urine kidney injury molecule-1Urine monocyte chemoattractant protein-1Soluble urokinase-type plasminogen activator receptorTumor necrosis factor receptor 2Monocyte chemoattractant protein-1Kidney tubule healthNecrosis factor receptor 2Pathophysiology of LVHUrine MCP-1Multivariable-adjusted modelsMCP-1 concentrationsBody mass indexProtein 1Child Cohort StudyA randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes
Wilson F, Yamamoto Y, Martin M, Coronel-Moreno C, Li F, Cheng C, Aklilu A, Ghazi L, Greenberg J, Latham S, Melchinger H, Mansour S, Moledina D, Parikh C, Partridge C, Testani J, Ugwuowo U. A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes. Nature Communications 2023, 14: 2826. PMID: 37198160, PMCID: PMC10192367, DOI: 10.1038/s41467-023-38532-3.Peer-Reviewed Original ResearchConceptsAcute kidney injuryUsual care groupKidney injuryCare groupAcute Kidney Injury OutcomesAlert groupNon-steroidal anti-inflammatory drugsComposite of progressionHours of randomizationMedications of interestAldosterone system inhibitorsClasses of medicationsProton pump inhibitorsRandomized clinical trialsAnti-inflammatory drugsClinical decision support systemNephrotoxic medicationsHospitalized adultsDiscontinuation ratesCertain medicationsPrimary outcomeSubstantial morbiditySystem inhibitorsPump inhibitorsParallel groupCurrent and Novel Biomarkers of Progression Risk in Children with Chronic Kidney Disease
Sandokji I, Xu Y, Denburg M, Furth S, Abraham A, Greenberg J. Current and Novel Biomarkers of Progression Risk in Children with Chronic Kidney Disease. Nephron 2023, 148: 1-10. PMID: 37232009, PMCID: PMC10840447, DOI: 10.1159/000530918.Peer-Reviewed Original ResearchChronic kidney diseaseCKD progressionKidney diseaseNovel biomarkersProgression of CKDLong-term adverse outcomesPediatric chronic kidney diseaseKidney function declineGlomerular filtration rateRisk of deathScreening studyCKD pathophysiologyFunction declineKidney biomarkersAdverse outcomesProgression riskFiltration rateClinical managementEarly recognitionClinical trialsPrognostic markerEarly diagnosisHigh riskClinical practicePromising biomarkerHypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children
Nugent J, Ghazi L, Yamamoto Y, Bakhoum C, Wilson F, Greenberg J. Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children. Journal Of The American Heart Association 2023, 12: e029059. PMID: 37119062, PMCID: PMC10227226, DOI: 10.1161/jaha.122.029059.Peer-Reviewed Original ResearchConceptsAcute kidney injuryBlood pressure variabilityBlood pressure measurementsHospitalized childrenKidney injuryBlood pressurePressure variabilityIncident acute kidney injuryTime-updated Cox modelsMean blood pressureEnd-organ complicationsAnalysis of hypertensionAKI riskConclusions HypertensionHypertension thresholdInpatient hypertensionNormotensive patientsOrgan complicationsNonpharmacologic interventionsRetrospective cohortPediatric inpatientsMultivariable modelPediatric encountersHypertensionCox modelAssociation of Kidney Tubule Biomarkers With Cardiac Structure and Function in the Multiethnic Study of Atherosclerosis
Wettersten N, Katz R, Greenberg J, Gutierrez O, Lima J, Sarnak M, Schrauben S, Deo R, Bonventre J, Vasan R, Kimmel P, Shlipak M, Ix J. Association of Kidney Tubule Biomarkers With Cardiac Structure and Function in the Multiethnic Study of Atherosclerosis. The American Journal Of Cardiology 2023, 196: 11-18. PMID: 37086700, PMCID: PMC10204591, DOI: 10.1016/j.amjcard.2023.02.031.Peer-Reviewed Original ResearchConceptsPlasma soluble urokinase plasminogen activator receptorSoluble urokinase plasminogen activator receptorKidney tubule injuryCardiac structural abnormalitiesUrokinase plasminogen activator receptorCardiovascular diseasePlasminogen activator receptorLower LVEFTubule injurySystemic inflammationVentricular mass/volume ratioStructural abnormalitiesChitinase-3-like protein 1Activator receptorTwofold greater concentrationCardiac magnetic resonance imagingKidney tubule healthChronic kidney diseaseIncident cardiovascular diseaseGlomerular filtration rateVentricular ejection fractionProtein 1Chemoattractant protein-1Multi-Ethnic StudyAlpha-1-microglobulinAssociation of clinical characteristics with urine uromodulin in children with chronic kidney disease
Faulkner S, Matheson M, Greenberg J, Garimella P, Furth S, Ix J, Bakhoum C. Association of clinical characteristics with urine uromodulin in children with chronic kidney disease. Pediatric Nephrology 2023, 38: 3859-3862. PMID: 36988691, PMCID: PMC10528151, DOI: 10.1007/s00467-023-05947-5.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseUrine uromodulinUromodulin levelsGlomerular diseaseKidney diseaseEtiology of CKDGraphical abstractA higher resolution versionOlder ageMultivariable linear regressionAge-specific referenceGreater kidney sizeHigh urine concentrationsRelationship of ageConclusionsAmong childrenTubular healthClinical characteristicsMedian eGFRMedian agePrimary outcomeKidney functionKidney sizeMultivariable modelChild CohortUrine concentrationsHealthy adultsDoes This Child With High Blood Pressure Have Secondary Hypertension?
Nugent J, Jiang K, Funaro M, Saran I, Young C, Ghazi L, Bakhoum C, Wilson F, Greenberg J. Does This Child With High Blood Pressure Have Secondary Hypertension? JAMA 2023, 329: 1012-1021. PMID: 36976276, DOI: 10.1001/jama.2023.3184.Peer-Reviewed Original ResearchConceptsBlood pressure loadAmbulatory blood pressure monitoringSecondary hypertensionBlood pressure monitoringPrimary hypertensionFamily historyBlood pressurePressure monitoringDiastolic blood pressure loadSystolic blood pressure loadSerum uric acid concentrationAmbulatory blood pressureHigh blood pressureHistory of prematurityPrimary care clinicsRisk of biasNumber of patientsDatabases of MEDLINEDiagnostic Accuracy Studies toolLower body weightRandom-effects modelingUric acid concentrationWeb of ScienceLikelihood ratioAsymptomatic presentation