2024
Urine Biomarkers of Kidney Tubule Health and Risk of Incident CKD in Persons Without Diabetes: The ARIC, MESA, and REGARDS Studies
Amatruda J, Katz R, Rebholz C, Sarnak M, Gutierrez O, Schrauben S, Greenberg J, Coresh J, Cushman M, Waikar S, Parikh C, Schelling J, Jogalekar M, Bonventre J, Vasan R, Kimmel P, Ix J, Shlipak M, Consortium C. Urine Biomarkers of Kidney Tubule Health and Risk of Incident CKD in Persons Without Diabetes: The ARIC, MESA, and REGARDS Studies. Kidney Medicine 2024, 6: 100834. PMID: 38826568, PMCID: PMC11141432, DOI: 10.1016/j.xkme.2024.100834.Peer-Reviewed Original ResearchAssociated with incident chronic kidney diseaseIncident chronic kidney diseaseChronic kidney diseaseUrine MCP-1Meta-analysisUrine biomarkersMCP-1A1M concentrationsMultivariable Cox proportional hazards regressionRisk of chronic kidney diseaseRisk of incident chronic kidney diseaseCox proportional hazards regressionIndependent of eGFRPrevalent chronic kidney diseaseCohort of adultsMeta-analysis of resultsA1MLong follow-up periodEarly chronic kidney diseaseFollow-up periodProportional hazards regressionUrine A1MARIC participantsREGARDS studyHealth markers
2023
Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study
de Fontnouvelle C, Zappitelli M, Thiessen-Philbrook H, Jia Y, Kimmel P, Kaufman J, Devarajan P, Parikh C, Greenberg J. Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study. Pediatric Nephrology 2023, 38: 2851-2860. PMID: 36790467, DOI: 10.1007/s00467-023-05886-1.Peer-Reviewed Original ResearchConceptsCyanotic heart diseaseChronic kidney diseaseEGFR declineCardiac surgeryHeart diseaseUrine uromodulinMedian eGFRIL-18Study visitGraphical abstractA higher resolution versionLong-term chronic kidney diseaseGlomerular filtration rate declineFaster eGFR declineIL-18 concentrationsLower median eGFRSurgical complexity scoreAcyanotic heart diseaseCongenital heart diseaseSubgroup of childrenTubular healthOverall cohortClinical factorsUrine biomarkersKidney diseaseUrinary biomarkers
2021
Urine Biomarkers of Kidney Tubule Health, Injury, and Inflammation are Associated with Progression of CKD in Children
Greenberg JH, Abraham AG, Xu Y, Schelling JR, Feldman HI, Sabbisetti VS, Ix JH, Jogalekar MP, Coca S, Waikar SS, Shlipak MG, Warady BA, Vasan RS, Kimmel PL, Bonventre JV, Denburg M, Parikh CR, Furth S, Consortium O. Urine Biomarkers of Kidney Tubule Health, Injury, and Inflammation are Associated with Progression of CKD in Children. Journal Of The American Society Of Nephrology 2021, 32: 2664-2677. PMID: 34544821, PMCID: PMC8722795, DOI: 10.1681/asn.2021010094.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlbuminuriaAlpha-GlobulinsBiomarkersChemokine CCL2ChildChitinase-3-Like Protein 1CreatinineDisease ProgressionEpidermal Growth FactorFemaleFollow-Up StudiesGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansKidney TubulesMaleNephritisProspective StudiesRenal Insufficiency, ChronicConceptsUrine KIM-1CKD progressionUrine biomarkersMicroglobulin concentrationsHighest quartileKIM-1MCP-1High riskRapid kidney function declineBiomarker concentrationsEGF concentrationsKidney tubule healthNovel urine biomarkersUrine biomarker concentrationsKidney function declineProgression of CKDUrine creatinine concentrationIdentification of childrenTubular healthMultivariable adjustmentComposite outcomeTubular injuryPrimary outcomeFunction declineStudy enrollment