2023
Current and Novel Biomarkers of Progression Risk in Children with Chronic Kidney Disease
Sandokji I, Xu Y, Denburg M, Furth S, Abraham A, Greenberg J. Current and Novel Biomarkers of Progression Risk in Children with Chronic Kidney Disease. Nephron 2023, 148: 1-10. PMID: 37232009, PMCID: PMC10840447, DOI: 10.1159/000530918.Peer-Reviewed Original ResearchChronic kidney diseaseCKD progressionKidney diseaseNovel biomarkersProgression of CKDLong-term adverse outcomesPediatric chronic kidney diseaseKidney function declineGlomerular filtration rateRisk of deathScreening studyCKD pathophysiologyFunction declineKidney biomarkersAdverse outcomesProgression riskFiltration rateClinical managementEarly recognitionClinical trialsPrognostic markerEarly diagnosisHigh riskClinical practicePromising biomarkerAssociation of Kidney Tubule Biomarkers With Cardiac Structure and Function in the Multiethnic Study of Atherosclerosis
Wettersten N, Katz R, Greenberg J, Gutierrez O, Lima J, Sarnak M, Schrauben S, Deo R, Bonventre J, Vasan R, Kimmel P, Shlipak M, Ix J. Association of Kidney Tubule Biomarkers With Cardiac Structure and Function in the Multiethnic Study of Atherosclerosis. The American Journal Of Cardiology 2023, 196: 11-18. PMID: 37086700, PMCID: PMC10204591, DOI: 10.1016/j.amjcard.2023.02.031.Peer-Reviewed Original ResearchConceptsPlasma soluble urokinase plasminogen activator receptorSoluble urokinase plasminogen activator receptorKidney tubule injuryCardiac structural abnormalitiesUrokinase plasminogen activator receptorCardiovascular diseasePlasminogen activator receptorLower LVEFTubule injurySystemic inflammationVentricular mass/volume ratioStructural abnormalitiesChitinase-3-like protein 1Activator receptorTwofold greater concentrationCardiac magnetic resonance imagingKidney tubule healthChronic kidney diseaseIncident cardiovascular diseaseGlomerular filtration rateVentricular ejection fractionProtein 1Chemoattractant protein-1Multi-Ethnic StudyAlpha-1-microglobulin
2022
Prenatal Metal Exposures and Associations with Kidney Injury Biomarkers in Children
Politis M, Yao M, Gennings C, Tamayo-Ortiz M, Valvi D, Kim-Schulze S, Qi J, Amarasiriwardena C, Pantic I, Tolentino M, Estrada-Gutierrez G, Greenberg J, Téllez-Rojo M, Wright R, Sanders A, Rosa M. Prenatal Metal Exposures and Associations with Kidney Injury Biomarkers in Children. Toxics 2022, 10: 692. PMID: 36422900, PMCID: PMC9699100, DOI: 10.3390/toxics10110692.Peer-Reviewed Original ResearchKidney injury biomarkersInjury biomarkersKidney biomarkersGamma-induced protein 10Glomerular filtration rateBirth cohort studyAlpha-1-microglobulinQuantile sum (WQS) regressionPrenatal metal exposureKidney injuryCohort studyUrinary CdPregnant womenSecond trimesterKidney diseasePrenatal exposureFiltration rateCystatin CUrinary metalsNull associationProtein 10A1MMetal exposureBiomarkersProtein 1