2024
Mortality burden of pre‐treatment weight loss in patients with non‐small‐cell lung cancer: A systematic literature review and meta‐analysis
Bonomi P, Crawford J, Dunne R, Roeland E, Smoyer K, Siddiqui M, McRae T, Rossulek M, Revkin J, Tarasenko L. Mortality burden of pre‐treatment weight loss in patients with non‐small‐cell lung cancer: A systematic literature review and meta‐analysis. Journal Of Cachexia Sarcopenia And Muscle 2024, 15: 1226-1239. PMID: 38650388, PMCID: PMC11294038, DOI: 10.1002/jcsm.13477.Peer-Reviewed Original ResearchNon-small-cell lung cancerInternational consensus criteriaHazard ratioStatistical heterogeneityMeta-analysisWeight lossLung cancerSubgroup analysisPre-treatment weight lossAssociated with inferior survivalImpact of cachexiaKaplan-Meier curvesRandom-effects modelInferior survivalOverall survivalWorse survivalSurvival outcomesHigher mortality riskAdult patientsPoor prognosisClinical decision-makingClinical trialsMultivariate analysisCachexiaIndependent reviewers screened titles
2023
The mortality burden of cachexia in patients with non-small cell lung cancer: A meta-analysis.
Bonomi P, Crawford J, Dunne R, Roeland E, Smoyer K, Siddiqui M, McRae T, Rossulek M, Revkin J, Tarasenko L. The mortality burden of cachexia in patients with non-small cell lung cancer: A meta-analysis. Journal Of Clinical Oncology 2023, 41: e24075-e24075. DOI: 10.1200/jco.2023.41.16_suppl.e24075.Peer-Reviewed Original ResearchNon-small cell lung cancerInternational consensus criteriaCell lung cancerOverall survivalSubgroup analysisWeight lossLung cancerStatistical heterogeneityTreatment of NSCLCInferior overall survivalImpact of cachexiaRisk of mortalityFunnel plot analysisHigher mortality riskPrevious weight lossHigh statistical heterogeneitySystematic literature reviewRandom-effects modelBase-case analysisSubstantial publication biasMeta-analysis resultsPoor outcomeMortality burdenCachexiaMortality risk