2021
Evaluating public acceptability of a potential Lyme disease vaccine using a population-based, cross-sectional survey in high incidence areas of the United States
Hook SA, Hansen AP, Niesobecki SA, Meek JI, Bjork JKH, Kough EM, Peterson MS, Schiffman EK, Rutz HJ, Rowe AJ, White JL, Peel JL, Biggerstaff BJ, Hinckley AF. Evaluating public acceptability of a potential Lyme disease vaccine using a population-based, cross-sectional survey in high incidence areas of the United States. Vaccine 2021, 40: 298-305. PMID: 34895785, DOI: 10.1016/j.vaccine.2021.11.065.Peer-Reviewed Original ResearchConceptsLyme disease vaccineDisease vaccineSurvey-weighted descriptive statisticsMultivariable multinomial logistic regression modelsCross-sectional studyLyme disease incidenceHigh incidence areaCross-sectional surveyLogistic regression modelsSafety concernsMultinomial logistic regression modelsVaccine uptakeAdults 45Vaccine parametersVaccine candidatesVaccine attitudesPrevention optionsHealthcare providersWeb-based surveyVaccineSociodemographic characteristicsIncidence areaLyme diseaseDisease incidenceIncidenceHospital-acquired influenza in the United States, FluSurv-NET, 2011–2012 through 2018–2019
Cummings C, O’Halloran A, Azenkot T, Reingold A, Alden N, Meek J, Anderson E, Ryan P, Kim S, McMahon M, McMullen C, Spina N, Bennett N, Billing L, Thomas A, Schaffner W, Talbot H, George A, Reed C, Garg S. Hospital-acquired influenza in the United States, FluSurv-NET, 2011–2012 through 2018–2019. Infection Control And Hospital Epidemiology 2021, 43: 1447-1453. PMID: 34607624, DOI: 10.1017/ice.2021.392.Peer-Reviewed Original ResearchConceptsHospital-acquired influenzaInfluenza-associated hospitalizationsHA influenzaHospital infection control measuresInfluenza Hospitalization Surveillance NetworkFacility-based testingPositive test dateRespiratory symptom onsetAnnual influenza vaccinationHA casesInfection control measuresSymptom onset dateCross-sectional studyYears of agePopulation-based ratesInfluenza vaccinationClinical characteristicsICU careSymptom onsetInfluenza vaccineMechanical ventilationSevere outcomesPatient outcomesInfluenza casesHospitalizationMorbidity and Mortality Among Adults Experiencing Homelessness Hospitalized With COVID-19
Cha S, Henry A, Montgomery M, Laws R, Pham H, Wortham J, Garg S, Kim L, Mosites E, Chai S, Kawasaki B, Meek J, Anderson E, Weigel A, Ryan P, Kim S, Como-Sabetti K, Torres S, Muse A, Bennett N, Billing L, Sutton M, Talbot H, Risk I. Morbidity and Mortality Among Adults Experiencing Homelessness Hospitalized With COVID-19. The Journal Of Infectious Diseases 2021, 224: 425-430. PMID: 33993309, PMCID: PMC8194564, DOI: 10.1093/infdis/jiab261.Peer-Reviewed Original ResearchConceptsMechanical ventilationCOVID-19-associated hospitalizationNon-Hispanic black personsCOVID-19Population-based surveillance dataHealth conditionsChronic health conditionsCoronavirus disease 2019ICU admissionClinical characteristicsRespiratory supportClinical outcomesSevere illnessDisease 2019High riskSurveillance dataAdults Experiencing HomelessnessAnalytic sampleEthnic minority groupsHousing statusBlack personsVentilationDeathOutcomesHospitalization
2019
Knowledge, attitudes, and behaviors regarding tick-borne disease prevention in endemic areas
Niesobecki S, Hansen A, Rutz H, Mehta S, Feldman K, Meek J, Niccolai L, Hook S, Hinckley A. Knowledge, attitudes, and behaviors regarding tick-borne disease prevention in endemic areas. Ticks And Tick-borne Diseases 2019, 10: 101264. PMID: 31431351, PMCID: PMC10948045, DOI: 10.1016/j.ttbdis.2019.07.008.Peer-Reviewed Original ResearchConceptsEndemic areasPrevalence of LDPrevention behaviorsShowering/bathingTick checksDisease preventionPerceived PrevalenceLyme disease vaccineLD endemic areasInsect repellentSelf-rated knowledgeUnadjusted analysesOdds ratioMultivariable modelFemale genderLD vaccineDisease vaccinePrevention optionsLocal prevalencePreventive behaviorsSociodemographic characteristicsPrevalenceMajority of respondentsOnly factorTick control
2017
Risk factors for tick exposure in suburban settings in the Northeastern United States
Mead P, Hook S, Niesobecki S, Ray J, Meek J, Delorey M, Prue C, Hinckley A. Risk factors for tick exposure in suburban settings in the Northeastern United States. Ticks And Tick-borne Diseases 2017, 9: 319-324. PMID: 29174449, DOI: 10.1016/j.ttbdis.2017.11.006.Peer-Reviewed Original Research
2016
Increased Antiviral Treatment Among Hospitalized Children and Adults With Laboratory-Confirmed Influenza, 2010–2015
Appiah GD, Chaves SS, Kirley PD, Miller L, Meek J, Anderson E, Oni O, Ryan P, Eckel S, Lynfield R, Bargsten M, Zansky SM, Bennett N, Lung K, McDonald-Hamm C, Thomas A, Brady D, Lindegren ML, Schaffner W, Hill M, Garg S, Fry AM, Campbell AP. Increased Antiviral Treatment Among Hospitalized Children and Adults With Laboratory-Confirmed Influenza, 2010–2015. Clinical Infectious Diseases 2016, 64: 364-367. PMID: 28013261, PMCID: PMC5480237, DOI: 10.1093/cid/ciw745.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntiviral AgentsChildChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornInfluenza A Virus, H1N1 SubtypeInfluenza, HumanLength of StayLongitudinal StudiesMaleMiddle AgedOseltamivirPandemicsProspective StudiesRetrospective StudiesSeasonsUnited StatesYoung AdultCase-Control Study of Vaccine Effectiveness in Preventing Laboratory-Confirmed Influenza Hospitalizations in Older Adults, United States, 2010–2011
Havers F, Sokolow L, Shay D, Farley M, Monroe M, Meek J, Kirley P, Bennett N, Morin C, Aragon D, Thomas A, Schaffner W, Zansky S, Baumbach J, Ferdinands J, Fry A. Case-Control Study of Vaccine Effectiveness in Preventing Laboratory-Confirmed Influenza Hospitalizations in Older Adults, United States, 2010–2011. Clinical Infectious Diseases 2016, 63: 1304-1311. PMID: 27486114, DOI: 10.1093/cid/ciw512.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed influenza hospitalizationsCase-control studyInfluenza hospitalizationsCase patientsAge groupsRecent hospitalizationRespiratory conditionsLower functional status scoresOlder adultsConditional logistic regression modelsAdjusted VE estimatesInfluenza-associated complicationsVaccine effectiveness dataChronic medical conditionsFunctional status scoresMonths of hospitalizationChronic health conditionsLogistic regression modelsPreventing LaboratoryInfluenza vaccinationVaccination statusVaccine effectivenessInfluenza seasonVE estimatesInfluenza infectionEffectiveness of Residential Acaricides to Prevent Lyme and Other Tick-borne Diseases in Humans
Hinckley A, Meek J, Ray J, Niesobecki S, Connally N, Feldman K, Jones E, Backenson P, White J, Lukacik G, Kay A, Miranda W, Mead P. Effectiveness of Residential Acaricides to Prevent Lyme and Other Tick-borne Diseases in Humans. The Journal Of Infectious Diseases 2016, 214: 182-188. PMID: 26740276, PMCID: PMC10874626, DOI: 10.1093/infdis/jiv775.Peer-Reviewed Original ResearchConceptsTick-borne diseasesHuman-tick encountersMajor public health concernPlacebo-controlled trialMedical record reviewHuman tick-borne diseasesReports of illnessPublic health concernPublic health authoritiesTick-borne diseaseRecord reviewTick biteTick exposureTreatment groupsHealth authoritiesDiseaseHealth concernQuesting ticksHuman outcomesTicksUse of acaricidesIllnessIncidenceTrialsWeeks
2015
Identification of population at risk for future Clostridium difficile infection following hospital discharge to be targeted for vaccine trials
Baggs J, Yousey-Hindes K, Ashley ED, Meek J, Dumyati G, Cohen J, Wise ME, McDonald LC, Lessa FC. Identification of population at risk for future Clostridium difficile infection following hospital discharge to be targeted for vaccine trials. Vaccine 2015, 33: 6241-6249. PMID: 26450660, PMCID: PMC4702247, DOI: 10.1016/j.vaccine.2015.09.078.Peer-Reviewed Original ResearchConceptsEmerging Infections ProgramHigh-risk groupRisk groupsRisk scoreIndex hospitalizationHospital dischargeDerivation cohortVaccine trialsValidation cohortDifficile infectionCox proportional hazards modelRisk of CDIAcute care hospitalizationIdentification of patientsClostridium difficile infectionHospital discharge dataNumber of hospitalizationsLow-risk groupProportional hazards modelLarge academic centerAdmission diagnosisPrimary outcomeInpatient stayPatient populationPharmacy dataImpact of Prompt Influenza Antiviral Treatment on Extended Care Needs After Influenza Hospitalization Among Community-Dwelling Older Adults
Chaves S, Pérez A, Miller L, Bennett N, Bandyopadhyay A, Farley M, Fowler B, Hancock E, Kirley P, Lynfield R, Ryan P, Morin C, Schaffner W, Sharangpani R, Lindegren M, Tengelsen L, Thomas A, Hill M, Bradley K, Oni O, Meek J, Zansky S, Widdowson M, Finelli L. Impact of Prompt Influenza Antiviral Treatment on Extended Care Needs After Influenza Hospitalization Among Community-Dwelling Older Adults. Clinical Infectious Diseases 2015, 61: 1807-1814. PMID: 26334053, DOI: 10.1093/cid/civ733.Peer-Reviewed Original ResearchConceptsIllness onsetCommunity-dwelling adultsAntiviral treatmentExtended careCare needsEarly treatmentInfluenza hospitalizationsHospital dischargeIntensive care unit admissionLaboratory-confirmed influenza hospitalizationsOlder adultsCommunity-dwelling older adultsInfluenza antiviral treatmentPrompt antiviral treatmentCare unit admissionImpact of influenzaLength of stayRisk survival analysisUnit admissionHospital lengthInfluenza seasonShortens hospitalizationNeurologic disordersRehabilitation facilityAntiviral agentsPneumonia among adults hospitalized with laboratory-confirmed seasonal influenza virus infection—United States, 2005–2008
Garg S, Jain S, Dawood FS, Jhung M, Pérez A, D’Mello T, Reingold A, Gershman K, Meek J, Arnold KE, Farley MM, Ryan P, Lynfield R, Morin C, Baumbach J, Hancock EB, Zansky S, Bennett N, Thomas A, Schaffner W, Finelli L. Pneumonia among adults hospitalized with laboratory-confirmed seasonal influenza virus infection—United States, 2005–2008. BMC Infectious Diseases 2015, 15: 369. PMID: 26307108, PMCID: PMC4550040, DOI: 10.1186/s12879-015-1004-y.Peer-Reviewed Original ResearchConceptsIntensive care unit admissionSeasonal influenza virus infectionICD-9-CM codesCertain underlying conditionsEmerging Infections ProgramCare unit admissionLaboratory-confirmed influenzaInfluenza virus infectionCause of deathCXR infiltrateUnit admissionICU admissionOlder patientsMechanical ventilationMultivariable analysisUnderlying conditionInfections ProgramChest radiographsVirus infectionPneumoniaSummary diagnosisInfectious diseasesInfluenzaPatientsAdultsObesity not associated with severity among hospitalized adults with seasonal influenza virus infection
Braun ES, Crawford FW, Desai MM, Meek J, Kirley PD, Miller L, Anderson EJ, Oni O, Ryan P, Lynfield R, Bargsten M, Bennett NM, Lung KL, Thomas A, Mermel E, Lindegren ML, Schaffner W, Price A, Chaves SS. Obesity not associated with severity among hospitalized adults with seasonal influenza virus infection. Infection 2015, 43: 569-575. PMID: 26148927, DOI: 10.1007/s15010-015-0802-x.Peer-Reviewed Original ResearchConceptsSeasonal influenza virus infectionMultivariate logistic regression modelSeasonal influenza severityLaboratory-confirmed influenzaRisk of pneumoniaInfluenza virus infectionLogistic regression modelsHospitalized adultsICU admissionObese patientsSevere obesityInfluenza severityArtificial ventilationVirus infectionWeight categoriesObesityPneumoniaSeverityRegression modelsAdultsUnderweightPatientsAdmissionInfectionInfluenzaDoes Influenza Vaccination Modify Influenza Severity? Data on Older Adults Hospitalized With Influenza During the 2012−2013 Season in the United States
Arriola C, Anderson E, Baumbach J, Bennett N, Bohm S, Hill M, Lindegren M, Lung K, Meek J, Mermel E, Miller L, Monroe M, Morin C, Oni O, Reingold A, Schaffner W, Thomas A, Zansky S, Finelli L, Chaves S. Does Influenza Vaccination Modify Influenza Severity? Data on Older Adults Hospitalized With Influenza During the 2012−2013 Season in the United States. The Journal Of Infectious Diseases 2015, 212: 1200-1208. PMID: 25821227, PMCID: PMC4683374, DOI: 10.1093/infdis/jiv200.Peer-Reviewed Original ResearchConceptsInfluenza vaccinationInfluenza severityDisease severityIntensive care unit admissionMultivariable logistic regression modelSevere influenza outcomesCare unit admissionLaboratory-confirmed influenzaMultivariable logistic regressionDiagnosis of pneumoniaLogistic regression modelsUnit admissionICU lengthVaccine effectivenessInfluenza seasonParametric survival modelsInfluenza outcomesVaccinated personsVaccinationPropensity scoreLogistic regressionOlder adultsPredominant strainSeverityInfluenzaBurden of Clostridium difficile Infection in the United States
Lessa F, Mu Y, Bamberg W, Beldavs Z, Dumyati G, Dunn J, Farley M, Holzbauer S, Meek J, Phipps E, Wilson L, Winston L, Cohen J, Limbago B, Fridkin S, Gerding D, McDonald L. Burden of Clostridium difficile Infection in the United States. New England Journal Of Medicine 2015, 372: 825-834. PMID: 25714160, PMCID: PMC10966662, DOI: 10.1056/nejmoa1408913.Peer-Reviewed Original ResearchConceptsClostridium difficile infectionDifficile infectionFirst recurrenceHealth care-associated infectionsCommunity-associated infectionsC. difficile infectionCare-associated infectionsPersons 65 yearsLaboratory-based surveillanceType 1 strainsNumber of deathsNational incidenceMolecular typingC. difficileInfectionIncidenceDeathUnited StatesRecurrenceGeographic areasSample of casesEstimated numberRegression modelsActive populationHealth
2014
Complications Among Adults Hospitalized With Influenza: A Comparison of Seasonal Influenza and the 2009 H1N1 Pandemic
Reed C, Chaves S, Perez A, D'Mello T, Kirley P, Aragon D, Meek J, Farley M, Ryan P, Lynfield R, Morin C, Hancock E, Bennett N, Zansky S, Thomas A, Lindegren M, Schaffner W, Finelli L. Complications Among Adults Hospitalized With Influenza: A Comparison of Seasonal Influenza and the 2009 H1N1 Pandemic. Clinical Infectious Diseases 2014, 59: 166-174. PMID: 24785230, PMCID: PMC7314251, DOI: 10.1093/cid/ciu285.Peer-Reviewed Original ResearchConceptsSeasonal influenzaMedical conditionsLower respiratory tract complicationsRevision discharge diagnosis codesPopulation-based surveillance systemCertain underlying medical conditionsYoung adultsInfluenza-associated complicationsInfluenza-related complicationsShock/sepsisTypical influenza seasonPattern of complicationsRespiratory tract complicationsUnderlying medical conditionsDischarge diagnosis codesChronic medical conditionsIntensive care unitAppropriate clinical managementSevere influenzaNeurologic complicationsInfluenza seasonOrgan failureCare unitMechanical ventilationClinical complications
2013
Effectiveness of Nonadjuvanted Monovalent Influenza A(H1N1)pdm09 Vaccines for Preventing Reverse Transcription Polymerase Chain Reaction–Confirmed Pandemic Influenza Hospitalizations: Case-Control Study of Children and Adults at 10 US Influenza Surveillance Network Sites
Thompson M, Sokolow L, Almendares O, Openo K, Farley M, Meek J, Ray J, Kirley P, Reingold A, Aragon D, Hancock E, Baumbach J, Schaffner W, Thomas A, Lynfield R, Ryan P, Monroe M, Cheng P, Fry A, Shay D. Effectiveness of Nonadjuvanted Monovalent Influenza A(H1N1)pdm09 Vaccines for Preventing Reverse Transcription Polymerase Chain Reaction–Confirmed Pandemic Influenza Hospitalizations: Case-Control Study of Children and Adults at 10 US Influenza Surveillance Network Sites. Clinical Infectious Diseases 2013, 57: 1587-1592. PMID: 23956169, PMCID: PMC7314184, DOI: 10.1093/cid/cit551.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed pandemic influenzaCommunity-matched controlsCase-control studyReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionInfluenza hospitalizationsMonovalent influenzaPandemic influenzaSingle dosePolymerase chain reactionVirus infectionInfluenzaChain reactionHospitalizationVaccinePatientsInfectionDose
2012
Guillain-Barré Syndrome During the 2009–2010 H1N1 Influenza Vaccination Campaign: Population-based Surveillance Among 45 Million Americans
Wise M, Viray M, Sejvar J, Lewis P, Baughman A, Connor W, Danila R, Giambrone G, Hale C, Hogan B, Meek J, Murphree R, Oh J, Reingold A, Tellman N, Conner S, Singleton J, Lu P, DeStefano F, Fridkin S, Vellozzi C, Morgan O. Guillain-Barré Syndrome During the 2009–2010 H1N1 Influenza Vaccination Campaign: Population-based Surveillance Among 45 Million Americans. American Journal Of Epidemiology 2012, 175: 1110-1119. PMID: 22582209, PMCID: PMC3888111, DOI: 10.1093/aje/kws196.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedChildChild, PreschoolFemaleGuillain-Barre SyndromeHealth PromotionHumansIncidenceInfantInfluenza A Virus, H1N1 SubtypeInfluenza VaccinesInfluenza, HumanMaleMiddle AgedPopulation SurveillanceProduct Surveillance, PostmarketingRisk AssessmentTime FactorsUnited StatesYoung AdultConceptsGuillain-Barré syndromePopulation-based surveillanceGBS casesPH1N1 vaccineInfluenza A (H1N1) 2009 monovalent vaccineRate of GBSEmerging Infections Program sitesSex-adjusted rate ratiosH1N1 influenza vaccineMedical record reviewVaccine coverage dataInfluenza vaccination campaignGBS incidencePH1N1 vaccinationInfluenza vaccineMonovalent vaccineRecord reviewIncident casesVaccine dosesExcess riskPatient interviewsGBS riskVaccine campaignVaccine historyVaccination campaignReduced Influenza Antiviral Treatment Among Children and Adults Hospitalized With Laboratory-Confirmed Influenza Infection in the Year After the 2009 Pandemic
Garg S, Chaves SS, Pérez A, D'Mello T, Gershman K, Meek J, Yousey-Hindes K, Arnold KE, Farley MM, Tengelsen L, Ryan P, Sharangpani R, Lynfield R, Morin C, Baumbach J, Hancock EB, Zansky S, Bennett NM, Fowler B, Bradley K, Thomas A, Cooper T, Schaffner W, Boulton R, Finelli L, Fry AM. Reduced Influenza Antiviral Treatment Among Children and Adults Hospitalized With Laboratory-Confirmed Influenza Infection in the Year After the 2009 Pandemic. Clinical Infectious Diseases 2012, 55: e18-e21. PMID: 22543024, DOI: 10.1093/cid/cis442.Peer-Reviewed Original Research
2011
Association Between Use of Statins and Mortality Among Patients Hospitalized With Laboratory-Confirmed Influenza Virus Infections: A Multistate Study
Vandermeer M, Thomas A, Kamimoto L, Reingold A, Gershman K, Meek J, Farley M, Ryan P, Lynfield R, Baumbach J, Schaffner W, Bennett N, Zansky S. Association Between Use of Statins and Mortality Among Patients Hospitalized With Laboratory-Confirmed Influenza Virus Infections: A Multistate Study. The Journal Of Infectious Diseases 2011, 205: 13-19. PMID: 22170954, DOI: 10.1093/infdis/jir695.Peer-Reviewed Original ResearchConceptsEmerging Infections ProgramLaboratory-confirmed influenzaInfluenza virus infectionVirus infectionPrevention's Emerging Infections ProgramMultivariable logistic regression modelInfluenza-related deathsChronic lung diseaseUse of statinsAdministration of statinsRisk of mortalityLogistic regression modelsProtective oddsHospitalized adultsInfluenza testsInfluenza vaccinationStatin useInfluenza seasonRenal diseaseAntiviral administrationImmunomodulatory effectsLung diseaseActive surveillanceInfections ProgramStatins
2010
Adult Hospitalizations for Laboratory-Positive Influenza during the 2005–2006 through 2007–2008 Seasons in the United States
Dao C, Kamimoto L, Nowell M, Reingold A, Gershman K, Meek J, Arnold K, Farley M, Ryan P, Lynfield R, Morin C, Baumbach J, Hancock E, Zansky S, Bennett N, Thomas A, Vandermeer M, Kirschke D, Schaffner W, Finelli L. Adult Hospitalizations for Laboratory-Positive Influenza during the 2005–2006 through 2007–2008 Seasons in the United States. The Journal Of Infectious Diseases 2010, 202: 881-888. PMID: 20677944, DOI: 10.1086/655904.Peer-Reviewed Original ResearchConceptsInfluenza-associated hospitalizationsInfluenza seasonEmerging Infections Program NetworkEmerging Infections Program sitesHospitalization discharge diagnosesInfections Program NetworkInfluenza-associated complicationsRate of hospitalizationLaboratory-positive casesAge-specific ratesTypes/subtypesAdult hospitalizationsHospitalization surveillanceClinical characteristicsInfluenza B.Discharge diagnosisMedical conditionsHospitalizationMetabolic diseasesIncreased circulationInfluenza virusOverall rateInfluenzaPredominant seasonsAge