2024
Characteristics of Patients With Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences
Guh A, Li R, Korhonen L, Winston L, Parker E, Czaja C, Johnston H, Basiliere E, Meek J, Olson D, Fridkin S, Wilson L, Perlmutter R, Holzbauer S, D’Heilly P, Phipps E, Flores K, Dumyati G, Pierce R, Ocampo V, Wilson C, Watkins J, Gerding D, McDonald L. Characteristics of Patients With Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences. Open Forum Infectious Diseases 2024, 11: ofae127. PMID: 38577028, PMCID: PMC10993058, DOI: 10.1093/ofid/ofae127.Peer-Reviewed Original ResearchRecurrent Clostridioides difficile infectionClostridioides difficile infectionInitial CDINitrofurantoin useMultiple recurrent Clostridioides difficile infectionsPositive testPositive C. difficile testMultiple CDI recurrencesMultivariate logistic regression analysisPrevent further recurrenceAssociated with increased riskIntervention study designProportion of patientsTime of presentationCharacteristics of patientsLogistic regression analysisClinical decision makingCDI recurrenceChronic hemodialysisAdjunctive therapyIncreased riskMultivariate analysisStudy designPatientsClinical setting
2022
Early Release - Economic Burden of Reported Lyme Disease in High-Incidence Areas, United States, 2014–2016 - Volume 28, Number 6—June 2022 - Emerging Infectious Diseases journal - CDC
Hook S, Jeon S, Niesobecki S, Hansen A, Meek J, Bjork J, Dorr F, Rutz H, Feldman K, White J, Backenson P, Shankar M, Meltzer M, Hinckley A. Early Release - Economic Burden of Reported Lyme Disease in High-Incidence Areas, United States, 2014–2016 - Volume 28, Number 6—June 2022 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2022, 28: 1170-1179. PMID: 35608612, PMCID: PMC9155891, DOI: 10.3201/eid2806.211335.Peer-Reviewed Original ResearchConceptsTotal societal costsSocietal costsLyme diseasePatient costsInfectious Diseases journal - CDCMean patient costMean societal costLyme disease endemic stateTotal patient costsCost-effectiveness analysisDisseminated diseaseProspective studyEarly diagnosisIncidence areaDiseaseEffective preventionProbable diseaseDemographic factorsPrevention methodsComprehensive economic evaluationEconomic evaluationPatientsVaccineIllnessDiagnosis
2016
Increased Antiviral Treatment Among Hospitalized Children and Adults With Laboratory-Confirmed Influenza, 2010–2015
Appiah GD, Chaves SS, Kirley PD, Miller L, Meek J, Anderson E, Oni O, Ryan P, Eckel S, Lynfield R, Bargsten M, Zansky SM, Bennett N, Lung K, McDonald-Hamm C, Thomas A, Brady D, Lindegren ML, Schaffner W, Hill M, Garg S, Fry AM, Campbell AP. Increased Antiviral Treatment Among Hospitalized Children and Adults With Laboratory-Confirmed Influenza, 2010–2015. Clinical Infectious Diseases 2016, 64: 364-367. PMID: 28013261, PMCID: PMC5480237, DOI: 10.1093/cid/ciw745.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntiviral AgentsChildChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornInfluenza A Virus, H1N1 SubtypeInfluenza, HumanLength of StayLongitudinal StudiesMaleMiddle AgedOseltamivirPandemicsProspective StudiesRetrospective StudiesSeasonsUnited StatesYoung AdultPrevalence of Respiratory Viral Pathogen Testing and Co-Detections Among Patients Hospitalized With Influenza, 2012–2015
Cohen J, Anderson E, Lindegren M, Kirley P, Zansky S, Thomas A, Lynfield R, Miller L, Bargsten M, Meek J, Bennett N, Collins J, Monroe M, Reed G, Tatham L, Fry A, Garg S. Prevalence of Respiratory Viral Pathogen Testing and Co-Detections Among Patients Hospitalized With Influenza, 2012–2015. Open Forum Infectious Diseases 2016, 3: 1744. PMCID: PMC7117592, DOI: 10.1093/ofid/ofw194.124.Peer-Reviewed Original Research
2015
Pneumonia among adults hospitalized with laboratory-confirmed seasonal influenza virus infection—United States, 2005–2008
Garg S, Jain S, Dawood FS, Jhung M, Pérez A, D’Mello T, Reingold A, Gershman K, Meek J, Arnold KE, Farley MM, Ryan P, Lynfield R, Morin C, Baumbach J, Hancock EB, Zansky S, Bennett N, Thomas A, Schaffner W, Finelli L. Pneumonia among adults hospitalized with laboratory-confirmed seasonal influenza virus infection—United States, 2005–2008. BMC Infectious Diseases 2015, 15: 369. PMID: 26307108, PMCID: PMC4550040, DOI: 10.1186/s12879-015-1004-y.Peer-Reviewed Original ResearchConceptsIntensive care unit admissionSeasonal influenza virus infectionICD-9-CM codesCertain underlying conditionsEmerging Infections ProgramCare unit admissionLaboratory-confirmed influenzaInfluenza virus infectionCause of deathCXR infiltrateUnit admissionICU admissionOlder patientsMechanical ventilationMultivariable analysisUnderlying conditionInfections ProgramChest radiographsVirus infectionPneumoniaSummary diagnosisInfectious diseasesInfluenzaPatientsAdultsObesity not associated with severity among hospitalized adults with seasonal influenza virus infection
Braun ES, Crawford FW, Desai MM, Meek J, Kirley PD, Miller L, Anderson EJ, Oni O, Ryan P, Lynfield R, Bargsten M, Bennett NM, Lung KL, Thomas A, Mermel E, Lindegren ML, Schaffner W, Price A, Chaves SS. Obesity not associated with severity among hospitalized adults with seasonal influenza virus infection. Infection 2015, 43: 569-575. PMID: 26148927, DOI: 10.1007/s15010-015-0802-x.Peer-Reviewed Original ResearchConceptsSeasonal influenza virus infectionMultivariate logistic regression modelSeasonal influenza severityLaboratory-confirmed influenzaRisk of pneumoniaInfluenza virus infectionLogistic regression modelsHospitalized adultsICU admissionObese patientsSevere obesityInfluenza severityArtificial ventilationVirus infectionWeight categoriesObesityPneumoniaSeverityRegression modelsAdultsUnderweightPatientsAdmissionInfectionInfluenza
2014
Lyme Disease Testing by Large Commercial Laboratories in the United States
Hinckley A, Connally N, Meek J, Johnson B, Kemperman M, Feldman K, White J, Mead P. Lyme Disease Testing by Large Commercial Laboratories in the United States. Clinical Infectious Diseases 2014, 59: 676-681. PMID: 24879782, PMCID: PMC4646413, DOI: 10.1093/cid/ciu397.Peer-Reviewed Original ResearchConceptsNumber of infectionsLarge commercial laboratoriesSource patientsLyme diseaseLyme disease testingFrequency of infectionTotal direct costsTwo-tiered testingCommercial laboratoriesPositive testPatientsDisease testingDiagnostic recommendationsVolume of testingLD testingInfectionDirect costsExposure historyLD testLaboratory resultsLaboratory testingUnited StatesAlternative testingTotal numberVital signs: improving antibiotic use among hospitalized patients.
Fridkin S, Baggs J, Fagan R, Magill S, Pollack LA, Malpiedi P, Slayton R, Khader K, Rubin MA, Jones M, Samore MH, Dumyati G, Dodds-Ashley E, Meek J, Yousey-Hindes K, Jernigan J, Shehab N, Herrera R, McDonald L, Schneider A, Srinivasan A. Vital signs: improving antibiotic use among hospitalized patients. MMWR Morbidity And Mortality Weekly Report 2014, 63: 194-200. PMID: 24598596, PMCID: PMC4584728.Peer-Reviewed Original ResearchConceptsClostridium difficile infectionAntibiotic prescribingAntibiotic useIncidence of CDIInpatient antibiotic useDays of therapyNational administrative databaseBroad-spectrum antibioticsHealth care providersAntibiotic-resistant infectionsHospitalized patientsSurgical wardsDifficile infectionImproved prescribingAdministrative databasesAntibiotic exposureIncorrect prescribingPrescribingPatientsHospitalPatient recordsPatient safetyU.S. hospitalsAntibiotic resistanceAntibiotics
2013
Effectiveness of Nonadjuvanted Monovalent Influenza A(H1N1)pdm09 Vaccines for Preventing Reverse Transcription Polymerase Chain Reaction–Confirmed Pandemic Influenza Hospitalizations: Case-Control Study of Children and Adults at 10 US Influenza Surveillance Network Sites
Thompson M, Sokolow L, Almendares O, Openo K, Farley M, Meek J, Ray J, Kirley P, Reingold A, Aragon D, Hancock E, Baumbach J, Schaffner W, Thomas A, Lynfield R, Ryan P, Monroe M, Cheng P, Fry A, Shay D. Effectiveness of Nonadjuvanted Monovalent Influenza A(H1N1)pdm09 Vaccines for Preventing Reverse Transcription Polymerase Chain Reaction–Confirmed Pandemic Influenza Hospitalizations: Case-Control Study of Children and Adults at 10 US Influenza Surveillance Network Sites. Clinical Infectious Diseases 2013, 57: 1587-1592. PMID: 23956169, PMCID: PMC7314184, DOI: 10.1093/cid/cit551.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed pandemic influenzaCommunity-matched controlsCase-control studyReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionInfluenza hospitalizationsMonovalent influenzaPandemic influenzaSingle dosePolymerase chain reactionVirus infectionInfluenzaChain reactionHospitalizationVaccinePatientsInfectionDose
2008
Performance of an Algorithm for Assessing Smallpox Risk among Patients with Rashes That May Be Confused with Smallpox
Hutchins S, Sulemana I, Heilpern K, Schaffner W, Wax G, Lerner E, Watson B, Baltimore R, Waltenburg R, Aronsky D, Coffin S, Ng G, Craig A, Behrman A, Meek J, Sherman E, Chavez S, Harpaz R, Schmid S. Performance of an Algorithm for Assessing Smallpox Risk among Patients with Rashes That May Be Confused with Smallpox. Clinical Infectious Diseases 2008, 46: s195-s203. PMID: 18284359, DOI: 10.1086/524383.Peer-Reviewed Original Research
2002
Superoxide Anion Production during Anaplasma phagocytophila Infection
Wang T, Malawista SE, Pal U, Grey M, Meek J, Akkoyunlu M, Thomas V, Fikrig E. Superoxide Anion Production during Anaplasma phagocytophila Infection. The Journal Of Infectious Diseases 2002, 186: 274-280. PMID: 12134266, DOI: 10.1086/341451.Peer-Reviewed Original ResearchConceptsChronic granulomatous diseaseRespiratory burstA. phagocytophilaRespiratory burst inhibitionNitroblue tetrazoliumPopulation of neutrophilsSuperoxide anion productionInfected miceGranulomatous diseaseMouse modelUse of assaysPolymorphonuclear leukocytesUninfected animalsAnaplasma phagocytophilaAnion productionNeutrophilsInfectionHL-60 cellsIndividual cell basisAssaysCell basisCellsPatientsLeukocytesDisease
2001
Retrospective validation of a surveillance system for unexplained illness and death: New Haven County, Connecticut.
Kluger M, Sofair A, Heye C, Meek J, Sodhi R, Hadler J. Retrospective validation of a surveillance system for unexplained illness and death: New Haven County, Connecticut. American Journal Of Public Health 2001, 91: 1214-9. PMID: 11499106, PMCID: PMC1446748, DOI: 10.2105/ajph.91.8.1214.Peer-Reviewed Original ResearchConceptsActive prospective surveillanceInfectious causesUnexplained illnessProspective surveillanceRetrospective surveillanceRetrospective validationProspective surveillance systemHospital discharge dataSurveillance systemSuch patientsAnnual incidenceStudy criteriaMedical recordsNew Haven CountyComputerized searchIllnessLess labor-intensive alternativeDeathLabor-intensive alternativePatientsReference populationSurveillanceCauseDischarge dataStudy counties