2023
684. Characteristics of Patients with Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences
Guh A, Li R, Korhonen L, Winston L, Parker E, Czaja C, Johnston H, Basiliere E, Meek J, Olson D, Fridkin S, Wilson L, Perlmutter R, Holzbauer S, D’Heilly P, Phipps E, Flores K, Dumyati G, Pierce R, Ocampo V, Wilson C, Watkins J, Gerding D, McDonald L. 684. Characteristics of Patients with Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences. Open Forum Infectious Diseases 2023, 10: ofad500.746. PMCID: PMC10677783, DOI: 10.1093/ofid/ofad500.746.Peer-Reviewed Original ResearchEmerging Infections ProgramClostridioides difficile infectionInitial Clostridioides difficile infectionInitial CDICharacteristics of patientsRecurrent CDIPositive testNitrofurantoin useRecent hospitalizationDifficile infectionPrevention's Emerging Infections ProgramRecurrent Clostridioides difficile infectionMultivariable logistic regression modelMultiple recurrent CDIPrevious positive testTime of presentationFull chart reviewGrant/research supportPrior positive testLogistic regression modelsRace/ethnicityChronic hemodialysisAdjunctive therapyChart reviewConclusions Patients
2022
2314. Hospitalizations and Antibiotic Use in the Year Prior to an Incident C. difficile Infection for Medicare Beneficiaries in Four States, 2016–2018
Hatfield K, Baggs J, Reddy S, Aranmolate R, Meek J, Fridkin S, Szydlowski J, Hatwar T, Dumyati G, Watkins J, Wilson C, McDonald L, Jernigan J, Guh A. 2314. Hospitalizations and Antibiotic Use in the Year Prior to an Incident C. difficile Infection for Medicare Beneficiaries in Four States, 2016–2018. Open Forum Infectious Diseases 2022, 9: ofac492.146. PMCID: PMC9752406, DOI: 10.1093/ofid/ofac492.146.Peer-Reviewed Original ResearchOutpatient antibiotic useEmerging Infections ProgramClostridioides difficile infectionAntibiotic useCDI casesDifficile infectionRisk factorsMedicare beneficiariesPrevention's Emerging Infections ProgramAntibiotic classesPrior yearAntibiotic stewardship effortsC. difficile infectionMultiple risk factorsInpatient hospitalization dataMedicare Provider AnalysisTiming of hospitalizationGrant/research supportDifferent antibiotic classesAntibiotic prescriptionsCase patientsMedian lengthOutpatient antibioticsCDI surveillanceCDI diagnosis
2021
Association between Socioeconomic Status and Incidence of Community-Associated Clostridioides difficile Infection — United States, 2014–2015
Skrobarcek K, Mu Y, Ahern J, Basiliere E, Beldavs Z, Brousseau G, Dumyati G, Fridkin S, Holzbauer S, Johnston H, Kainer M, Meek J, Ocampo V, Parker E, Perlmutter R, Phipps E, Winston L, Guh A. Association between Socioeconomic Status and Incidence of Community-Associated Clostridioides difficile Infection — United States, 2014–2015. Clinical Infectious Diseases 2021, 73: 722-725. PMID: 33462596, PMCID: PMC8286972, DOI: 10.1093/cid/ciab042.Peer-Reviewed Original Research
2018
482. Association between Socioeconomic Status Factors and Incidence of Community-Associated Clostridium difficile Infection Utilizing Factor Analysis—United States, 2014–2015
Skrobarcek K, Mu Y, Ahern J, Beldavs Z, Brousseau G, Dumyati G, Farley M, Holzbauer S, Kainer M, Meek J, Perlmutter R, Phipps E, Winston L, Guh A. 482. Association between Socioeconomic Status Factors and Incidence of Community-Associated Clostridium difficile Infection Utilizing Factor Analysis—United States, 2014–2015. Open Forum Infectious Diseases 2018, 5: s179-s179. PMCID: PMC6253049, DOI: 10.1093/ofid/ofy210.491.Peer-Reviewed Original ResearchClostridium difficile infectionEmerging Infections ProgramSocioeconomic status factorsCDC's Emerging Infections ProgramCA-CDI casesCDI risk factorsSES variablesDays of hospitalizationHealthcare-associated infectionsLow-income areasStatus factorsLow incomeMultivariable analysisCA-CDICDI surveillanceDifficile infectionRisk factorsIncidence rateInfections ProgramPositive testPrevention strategiesCensus tractsHealth disparitiesSocial determinantsHealth resources492. Long-Term Outcomes of Clostridium difficile Infection Among Medicare Beneficiaries
Hatfield K, Baggs J, Winston L, Parker E, Martin B, Meek J, Olson D, Farley M, Revis A, Holzbauer S, Bye M, Wilson L, Perlmutter R, Phipps E, Pierce R, Ocampo V, Kainer M, Smith M, McDonald L, Jernigan J, Guh A. 492. Long-Term Outcomes of Clostridium difficile Infection Among Medicare Beneficiaries. Open Forum Infectious Diseases 2018, 5: s182-s182. PMCID: PMC6253260, DOI: 10.1093/ofid/ofy210.501.Peer-Reviewed Original ResearchClostridium difficile infectionEmerging Infections ProgramDifficile infectionInclusion criteriaCommon healthcare-associated infectionsPrevention's Emerging Infections ProgramMultivariable logistic regression modelICD-9-CM codesOlder adultsDifficile stool testMedicaid Services beneficiariesNumber of hospitalizationsHealthcare-associated infectionsSkilled nursing facilitiesLong-term riskLogistic regression modelsSame catchment areaExcess morbidityHospitalization statusStool testPoor outcomeTerm outcomesAdjusted oddsCDI casesChronic conditions
2016
Burden of Nursing Home-Onset Clostridium difficile Infection in the United States: Estimates of Incidence and Patient Outcomes
Hunter J, Mu Y, Dumyati G, Farley M, Winston L, Johnston H, Meek J, Perlmutter R, Holzbauer S, Beldavs Z, Phipps E, Dunn J, Cohen J, Avillan J, Stone N, Gerding D, McDonald L, Lessa F. Burden of Nursing Home-Onset Clostridium difficile Infection in the United States: Estimates of Incidence and Patient Outcomes. Open Forum Infectious Diseases 2016, 3: ofv196. PMID: 26798767, PMCID: PMC4719744, DOI: 10.1093/ofid/ofv196.Peer-Reviewed Original ResearchClostridium difficile infectionDifficile infectionPatient outcomesPopulation-based surveillanceAcute care settingAppropriate antibiotic useEstimates of incidenceMedian ageSubstantial morbidityPositive stoolsMedical recordsRisk factorsAdvanced ageAntibiotic useInfection preventionAntibiotic exposureHome residentsNational incidenceCare settingsPositive specimenNational estimatesIncidenceSpecimen collectionAgeStool
2015
Identification of population at risk for future Clostridium difficile infection following hospital discharge to be targeted for vaccine trials
Baggs J, Yousey-Hindes K, Ashley ED, Meek J, Dumyati G, Cohen J, Wise ME, McDonald LC, Lessa FC. Identification of population at risk for future Clostridium difficile infection following hospital discharge to be targeted for vaccine trials. Vaccine 2015, 33: 6241-6249. PMID: 26450660, PMCID: PMC4702247, DOI: 10.1016/j.vaccine.2015.09.078.Peer-Reviewed Original ResearchConceptsEmerging Infections ProgramHigh-risk groupRisk groupsRisk scoreIndex hospitalizationHospital dischargeDerivation cohortVaccine trialsValidation cohortDifficile infectionCox proportional hazards modelRisk of CDIAcute care hospitalizationIdentification of patientsClostridium difficile infectionHospital discharge dataNumber of hospitalizationsLow-risk groupProportional hazards modelLarge academic centerAdmission diagnosisPrimary outcomeInpatient stayPatient populationPharmacy dataAssociation Between Outpatient Antibiotic Prescribing Practices and Community-Associated Clostridium difficile Infection
Dantes R, Mu Y, Hicks L, Cohen J, Bamberg W, Beldavs Z, Dumyati G, Farley M, Holzbauer S, Meek J, Phipps E, Wilson L, Winston L, McDonald L, Lessa F. Association Between Outpatient Antibiotic Prescribing Practices and Community-Associated Clostridium difficile Infection. Open Forum Infectious Diseases 2015, 2: ofv113. PMID: 26509182, PMCID: PMC4551478, DOI: 10.1093/ofid/ofv113.Peer-Reviewed Original ResearchClostridium difficile infectionCA-CDI ratesOutpatient antibiotic prescribingAntibiotic useAntibiotic prescribingDifficile infectionCommunity-Associated Clostridium difficile InfectionIMS Health Xponent databaseOutpatient antibiotic prescribing practicesAmoxicillin/clavulanic acidCA-CDI casesSurveillance area residentAntibiotic prescribing ratesAntibiotic prescription ratesAntibiotic prescribing practicesCourse of antibioticsOral antibiotic prescriptionsLaboratory-based surveillance dataOutpatient antibiotic useCDI preventionAntibiotic prescriptionsPrescribing ratesHospital admissionPrescription ratesPrescribing practicesBurden of Clostridium difficile Infection in the United States
Lessa F, Mu Y, Bamberg W, Beldavs Z, Dumyati G, Dunn J, Farley M, Holzbauer S, Meek J, Phipps E, Wilson L, Winston L, Cohen J, Limbago B, Fridkin S, Gerding D, McDonald L. Burden of Clostridium difficile Infection in the United States. New England Journal Of Medicine 2015, 372: 825-834. PMID: 25714160, PMCID: PMC10966662, DOI: 10.1056/nejmoa1408913.Peer-Reviewed Original ResearchConceptsClostridium difficile infectionDifficile infectionFirst recurrenceHealth care-associated infectionsCommunity-associated infectionsC. difficile infectionCare-associated infectionsPersons 65 yearsLaboratory-based surveillanceType 1 strainsNumber of deathsNational incidenceMolecular typingC. difficileInfectionIncidenceDeathUnited StatesRecurrenceGeographic areasSample of casesEstimated numberRegression modelsActive populationHealth
2014
Clostridium difficile Infection Among Children Across Diverse US Geographic Locations
Wendt J, Cohen J, Mu Y, Dumyati G, Dunn J, Holzbauer S, Winston L, Johnston H, Meek J, Farley M, Wilson L, Phipps E, Beldavs Z, Gerding D, McDonald L, Gould C, Lessa F. Clostridium difficile Infection Among Children Across Diverse US Geographic Locations. Pediatrics 2014, 133: 651-658. PMID: 24590748, PMCID: PMC10932476, DOI: 10.1542/peds.2013-3049.Peer-Reviewed Original ResearchConceptsClostridium difficile infectionAge groupsCDI incidenceDifficile infectionCommunity-associated casesProportion of casesYears of ageHealth care facilitiesYoung childrenSimilar disease severityUnnecessary antimicrobial useUS geographic areasHospital admissionClinical presentationCDI surveillanceOutpatient settingCDI casesC difficileEtiologic roleClinical dataSevere diseaseStool collectionCare facilitiesDisease severityCA casesVital signs: improving antibiotic use among hospitalized patients.
Fridkin S, Baggs J, Fagan R, Magill S, Pollack LA, Malpiedi P, Slayton R, Khader K, Rubin MA, Jones M, Samore MH, Dumyati G, Dodds-Ashley E, Meek J, Yousey-Hindes K, Jernigan J, Shehab N, Herrera R, McDonald L, Schneider A, Srinivasan A. Vital signs: improving antibiotic use among hospitalized patients. MMWR Morbidity And Mortality Weekly Report 2014, 63: 194-200. PMID: 24598596, PMCID: PMC4584728.Peer-Reviewed Original ResearchConceptsClostridium difficile infectionAntibiotic prescribingAntibiotic useIncidence of CDIInpatient antibiotic useDays of therapyNational administrative databaseBroad-spectrum antibioticsHealth care providersAntibiotic-resistant infectionsHospitalized patientsSurgical wardsDifficile infectionImproved prescribingAdministrative databasesAntibiotic exposureIncorrect prescribingPrescribingPatientsHospitalPatient recordsPatient safetyU.S. hospitalsAntibiotic resistanceAntibiotics
2011
Clostridium difficile Infection in Outpatients, Maryland and Connecticut, USA, 2002–2007 - Volume 17, Number 10—October 2011 - Emerging Infectious Diseases journal - CDC
Hirshon JM, Thompson AD, Limbago B, McDonald LC, Bonkosky M, Heimer R, Meek J, Mai V, Braden C. Clostridium difficile Infection in Outpatients, Maryland and Connecticut, USA, 2002–2007 - Volume 17, Number 10—October 2011 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2011, 17: 1946-1949. PMID: 22000379, PMCID: PMC3310666, DOI: 10.3201/eid1710.110069.Peer-Reviewed Original Research