2018
A multicenter examination and strategic revisions of the Yale Global Tic Severity Scale
McGuire JF, Piacentini J, Storch EA, Murphy TK, Ricketts EJ, Woods DW, Walkup JW, Peterson AL, Wilhelm S, Lewin AB, McCracken JT, Leckman JF, Scahill L. A multicenter examination and strategic revisions of the Yale Global Tic Severity Scale. Neurology 2018, 90: e1711-e1719. PMID: 29653992, PMCID: PMC5952973, DOI: 10.1212/wnl.0000000000005474.Peer-Reviewed Original ResearchConceptsTic symptom severityTic scoreTIC numbersYale Global Tic Severity Scale (YGTSS) scoresSymptom severityYale Global Tic Severity ScaleYGTSS total tic scoreTotal tic scoreSimilar clinical characteristicsInternal consistencySeverity Scale scoreCross-sectional studyTic Severity ScaleDelphi consensus processClinical characteristicsPhonic ticsTic disordersMulticenter examinationImpairment scoresGood internal consistencySeverity ScaleScale scoreSymptom ChecklistDiagnostic InterviewStrong internal consistency
2012
FAMILY ACCOMMODATION IN PEDIATRIC ANXIETY DISORDERS
Lebowitz ER, Woolston J, Bar‐Haim Y, Calvocoressi L, Dauser C, Warnick E, Scahill L, Chakir AR, Shechner T, Hermes H, Vitulano LA, King RA, Leckman JF. FAMILY ACCOMMODATION IN PEDIATRIC ANXIETY DISORDERS. Depression And Anxiety 2012, 30: 47-54. PMID: 22965863, PMCID: PMC3932435, DOI: 10.1002/da.21998.Peer-Reviewed Original ResearchConceptsChildhood anxiety disordersFamily Accommodation ScaleFamily accommodationAnxiety disordersMeasures of anxietyFamilies of childrenObsessive-compulsive disorderGood internal consistencyTwo-factor solutionAnxious childrenPediatric anxietyAccommodation ScaleSeparation anxietyGreater symptom severityAnxiety symptomsCompulsive disorderDivergent validityFamily routinesAnxietyDiagnostic InterviewPoor treatment outcomesInternal consistencySymptom severityMost parentsFactor analysis
2011
Coercive and disruptive behaviors in pediatric obsessive–compulsive disorder
Lebowitz ER, Omer H, Leckman JF. Coercive and disruptive behaviors in pediatric obsessive–compulsive disorder. Depression And Anxiety 2011, 28: 899-905. PMID: 21769998, PMCID: PMC4006629, DOI: 10.1002/da.20858.Peer-Reviewed Original Research
2009
Dimensional predictors of response to SRI pharmacotherapy in obsessive–compulsive disorder
Landeros-Weisenberger A, Bloch MH, Kelmendi B, Wegner R, Nudel J, Dombrowski P, Pittenger C, Krystal JH, Goodman WK, Leckman JF, Coric V. Dimensional predictors of response to SRI pharmacotherapy in obsessive–compulsive disorder. Journal Of Affective Disorders 2009, 121: 175-179. PMID: 19577308, PMCID: PMC3974618, DOI: 10.1016/j.jad.2009.06.010.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSRI responseSymptom dimensionsOpen-label continuation phaseClinical Global Improvement ScaleGlobal Improvement ScaleCentral serotonin systemInitial positive responseYale-Brown ObsessiveContinuation phaseMinor symptomsOrdinal logistic regressionClinical trialsSerotonin systemTreatment responseSame patientImprovement ScaleSRI treatmentPatientsSignificant associationLogistic regressionCompulsive ScaleOCD patientsOCD subjectsSymptomsValidation of the University of São Paulo Sensory Phenomena Scale:Initial Psychometric Properties
Rosario MC, Prado HS, Borcato S, Diniz JB, Shavitt RG, Hounie AG, Mathis ME, Mastrorosa RS, Velloso P, Perin EA, Fossaluza V, Pereira CA, Geller D, Leckman J, Miguel E. Validation of the University of São Paulo Sensory Phenomena Scale:Initial Psychometric Properties. CNS Spectrums 2009, 14: 315-323. PMID: 19668122, DOI: 10.1017/s1092852900020319.Peer-Reviewed Original ResearchConceptsOpen clinical interviewClinical InterviewYale-Brown ObsessiveObsessive-compulsive disorderFourth Edition Axis I DisordersEarly-onset OCD patientsYale Global Tic Severity ScaleSensory phenomenaCompulsive ScaleOCD patientsOCD subjectsAxis I DisordersTic Severity ScaleSão Paulo Sensory Phenomena ScaleSignificant differencesBeck Depression InventoryBeck Anxiety InventorySeverity scoreI disordersInter-rater reliabilityInitial psychometric propertiesSeverity ScalePremonitory urgesPatientsDepression InventoryPerfectionism and sensory phenomena: phenotypic components of obsessive-compulsive disorder
Lee JC, Prado HS, Diniz JB, Borcato S, da Silva CB, Hounie AG, Miguel EC, Leckman JF, do Rosário MC. Perfectionism and sensory phenomena: phenotypic components of obsessive-compulsive disorder. Comprehensive Psychiatry 2009, 50: 431-436. PMID: 19683613, DOI: 10.1016/j.comppsych.2008.11.007.Peer-Reviewed Original Research
2008
Four-Factor Structure of Obsessive-Compulsive Disorder Symptoms in Children, Adolescents, and Adults
Stewart SE, Rosario MC, Baer L, Carter AS, Brown TA, Scharf JM, Illmann C, Leckman JF, Sukhodolsky D, Katsovich L, Rasmussen S, Goodman W, Delorme R, Leboyer M, Chabane N, Jenike MA, Geller DA, Pauls DL. Four-Factor Structure of Obsessive-Compulsive Disorder Symptoms in Children, Adolescents, and Adults. Journal Of The American Academy Of Child & Adolescent Psychiatry 2008, 47: 763-772. PMID: 18520961, DOI: 10.1097/chi.0b013e318172ef1e.Peer-Reviewed Original ResearchConceptsConfirmatory factor analysisAdult age groupsAge groupsAge group samplesAdult groupFour-factor solutionOngoing translational researchSymptom dimensionsPrevious confirmatory factor analysisObsessive-compulsive disorder symptomsMultiple-group confirmatory factor analysisCategory-based modelComparable model fitOCD symptom dimensions
2007
Gender differences in obsessive–compulsive symptom dimensions
Labad J, Menchon JM, Alonso P, Segalas C, Jimenez S, Jaurrieta N, Leckman JF, Vallejo J. Gender differences in obsessive–compulsive symptom dimensions. Depression And Anxiety 2007, 25: 832-838. PMID: 17436312, DOI: 10.1002/da.20332.Peer-Reviewed Original Research
2006
The Dimensional Yale–Brown Obsessive–Compulsive Scale (DY-BOCS): an instrument for assessing obsessive–compulsive symptom dimensions
Rosario-Campos MC, Miguel EC, Quatrano S, Chacon P, Ferrao Y, Findley D, Katsovich L, Scahill L, King RA, Woody SR, Tolin D, Hollander E, Kano Y, Leckman JF. The Dimensional Yale–Brown Obsessive–Compulsive Scale (DY-BOCS): an instrument for assessing obsessive–compulsive symptom dimensions. Molecular Psychiatry 2006, 11: 495-504. PMID: 16432526, DOI: 10.1038/sj.mp.4001798.Peer-Reviewed Original Research
2004
Obsessive‐compulsive symptoms in parents of Tourette syndrome probands and autism spectrum disorder probands
KANO Y, OHTA M, NAGAI Y, PAULS DL, LECKMAN JF. Obsessive‐compulsive symptoms in parents of Tourette syndrome probands and autism spectrum disorder probands. Psychiatry And Clinical Neurosciences 2004, 58: 348-352. PMID: 15298645, DOI: 10.1111/j.1440-1819.2004.01266.x.Peer-Reviewed Original Research
2003
Development of the Yale Children’s Global Stress Index (YCGSI) and Its Application in Children and Adolescents With Tourette’s Syndrome and Obsessive-Compulsive Disorder
FINDLEY DB, LECKMAN JF, KATSOVICH L, LIN H, ZHANG H, GRANTZ H, OTKA J, LOMBROSO PJ, KING RA. Development of the Yale Children’s Global Stress Index (YCGSI) and Its Application in Children and Adolescents With Tourette’s Syndrome and Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2003, 42: 450-457. PMID: 12649632, DOI: 10.1097/01.chi.0000046816.95464.ef.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTourette syndromeDaily Life Stressors ScalePsychosocial stressAge-matched control subjectsClinician ratingsClinical rating instrumentGlobal clinician ratingsTime pointsGlobal Stress IndexCross-sectional ratingsEarly-onset obsessive-compulsive disorderPsychometric propertiesControl subjectsClinical severityObsessive-compulsive symptom severityStudy of childrenAcceptable psychometric propertiesStress indexSymptom severitySyndromePossible differential contributionInterrater reliabilityStressor ScaleDisorders
1999
The Tourette Syndrome Diagnostic Confidence Index
Robertson MM, Banerjee S, Kurlan R, Cohen DJ, Leckman JF, McMahon W, Pauls DL, Sandor P, van de Wetering B. The Tourette Syndrome Diagnostic Confidence Index. Neurology 1999, 53: 2108-2112. PMID: 10599790, DOI: 10.1212/wnl.53.9.2108.Peer-Reviewed Original ResearchConceptsDiagnostic Confidence IndexLifetime likelihoodRate symptom severityPsychometric propertiesClinical characteristicsConsecutive patientsTS clinicCase ascertainmentDiagnostic criteriaConsensus workshopSymptom severityClinical membersClinicPopulation of interestSeverityLifetime measuresPatientsExpert groupSymptomsLikelihood
1997
Symptoms of obsessive-compulsive disorder
Leckman JF, Grice DE, Boardman J, Zhang H, Vitale A, Bondi C, Alsobrook J, Peterson BS, Cohen DJ, Rasmussen SA, Goodman WK, McDougle CJ, Pauls DL. Symptoms of obsessive-compulsive disorder. American Journal Of Psychiatry 1997, 154: 911-917. PMID: 9210740, DOI: 10.1176/ajp.154.7.911.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMultiple psychological domainsYale-Brown Obsessive Compulsive Scale Symptom ChecklistTypes of obsessionsCompulsive Scale Symptom ChecklistSocial relatednessPsychological domainSymptom dimensionsPrincipal component factor analysisCorrelational relationshipsSymptom ChecklistDiverse motor behaviorsMotor behaviorFactor analysisExploratory analysisVarimax rotationTreatment response studiesObsessionDisordersIndependent groupsEmotionsCognitionPerceptionSymptomsCompulsion
1992
K-ABC profiles in children with fragile X syndrome, Down syndrome, and nonspecific mental retardation.
Hodapp RM, Leckman JF, Dykens EM, Sparrow SS, Zelinsky DG, Ort SI. K-ABC profiles in children with fragile X syndrome, Down syndrome, and nonspecific mental retardation. American Journal On Intellectual And Developmental Disabilities 1992, 97: 39-46. PMID: 1386742.Peer-Reviewed Original Research
1987
Strengths and weaknesses in the intellectual functioning of males with fragile X syndrome.
Dykens EM, Hodapp RM, Leckman JF. Strengths and weaknesses in the intellectual functioning of males with fragile X syndrome. American Journal On Intellectual And Developmental Disabilities 1987, 92: 234-6. PMID: 3434594.Peer-Reviewed Original ResearchConceptsShort-term memoryKaufman Assessment BatteryFragile X syndromePerceptual closureAchievement domainsArithmetic skillsIntellectual functioningAssessment BatteryX syndromeIntellectual strengthsSequential processingPrevious researchOverall levelMemoryFunctioningSkillsSignificant strengthImpairment