2020
Autoantibody Biomarkers for Basal Ganglia Encephalitis in Sydenham Chorea and Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infections
Chain JL, Alvarez K, Mascaro-Blanco A, Reim S, Bentley R, Hommer R, Grant P, Leckman JF, Kawikova I, Williams K, Stoner JA, Swedo SE, Cunningham MW. Autoantibody Biomarkers for Basal Ganglia Encephalitis in Sydenham Chorea and Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infections. Frontiers In Psychiatry 2020, 11: 564. PMID: 32670106, PMCID: PMC7328706, DOI: 10.3389/fpsyt.2020.00564.Peer-Reviewed Original ResearchPediatric autoimmune neuropsychiatric disordersAnti-neuronal autoantibodiesSerum autoantibody titersAutoimmune neuropsychiatric disordersSydenham's choreaAutoantibody titersEnzyme-linked immunosorbent assayCerebrospinal fluidNeuronal autoantigensNeuropsychiatric disordersPANDAS patientsPANDAS subjectsStreptococcal infectionHealthy controlsAcute symptomatic phaseBasal ganglia encephalitisGroup of autoantibodiesHealthy control subjectsCaMKII activationAttention deficit hyperactivity disorderHuman neuronal cellsDeficit hyperactivity disorderGroup of childrenAutoantibody biomarkersObsessive-compulsive disorder
2017
Longitudinal outcomes of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS)
Leon J, Hommer R, Grant P, Farmer C, D’Souza P, Kessler R, Williams K, Leckman JF, Swedo S. Longitudinal outcomes of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS). European Child & Adolescent Psychiatry 2017, 27: 637-643. PMID: 29119300, DOI: 10.1007/s00787-017-1077-9.Peer-Reviewed Original ResearchConceptsPediatric autoimmune neuropsychiatric disordersAutoimmune neuropsychiatric disordersIntravenous immunoglobulinStreptococcal infectionDose of IVIGNeuropsychiatric disordersPlacebo-controlled trialSignificant obsessive-compulsive symptomsPopulation of childrenCognitive behavioral therapySubacute illnessSydenham's choreaBlinded infusionChronic coursePsychiatric medicationsTreatment modalitiesSpecific symptomsChildhood-onset OCDLongitudinal courseNatural historyObsessive-compulsive symptomsBehavioral therapyExacerbationParents of participantsTelephone interviews
2013
Brain Human Monoclonal Autoantibody from Sydenham Chorea Targets Dopaminergic Neurons in Transgenic Mice and Signals Dopamine D2 Receptor: Implications in Human Disease
Cox CJ, Sharma M, Leckman JF, Zuccolo J, Zuccolo A, Kovoor A, Swedo SE, Cunningham MW. Brain Human Monoclonal Autoantibody from Sydenham Chorea Targets Dopaminergic Neurons in Transgenic Mice and Signals Dopamine D2 Receptor: Implications in Human Disease. The Journal Of Immunology 2013, 191: 5524-5541. PMID: 24184556, PMCID: PMC3848617, DOI: 10.4049/jimmunol.1102592.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, BacterialAutoantibodiesBasal GangliaChildChoreaCross ReactionsDopamineDopaminergic NeuronsG(M1) GangliosideHEK293 CellsHumansImmunoglobulin GMiceMice, Inbred C57BLMice, TransgenicReceptors, Dopamine D2Recombinant Fusion ProteinsRheumatic FeverSignal TransductionStreptococcal InfectionsTransgenesConceptsSydenham's choreaDopamine D2 receptorsDopaminergic neuronsD2 receptorsTransgenic micePediatric autoimmune neuropsychiatric disordersDose-dependent inhibitoryMain neurologic manifestationsAutoimmune neuropsychiatric disordersBehavioral disordersHuman monoclonal autoantibodiesBrain AgsNeurologic manifestationsRheumatic feverChoreiform movementsTg miceBasal gangliaHuman dopamine D2 receptorAb reactivityTyrosine hydroxylaseAutoantibodiesB cellsMonoclonal autoantibodiesNeuropsychiatric disordersD2R
2012
Behavioral, Pharmacological, and Immunological Abnormalities after Streptococcal Exposure: A Novel Rat Model of Sydenham Chorea and Related Neuropsychiatric Disorders
Brimberg L, Benhar I, Mascaro-Blanco A, Alvarez K, Lotan D, Winter C, Klein J, Moses AE, Somnier FE, Leckman JF, Swedo SE, Cunningham MW, Joel D. Behavioral, Pharmacological, and Immunological Abnormalities after Streptococcal Exposure: A Novel Rat Model of Sydenham Chorea and Related Neuropsychiatric Disorders. Neuropsychopharmacology 2012, 37: 2076-2087. PMID: 22534626, PMCID: PMC3398718, DOI: 10.1038/npp.2012.56.Peer-Reviewed Original ResearchConceptsSydenham's choreaNeuropsychiatric disordersStreptococcal exposureImmunological abnormalitiesMotor symptomsRat modelAnimal modelsSelective serotonin reuptake inhibitor paroxetineGroup A streptococcal infectionsSerotonin reuptake inhibitor paroxetineSK-N-SH neuronal cellsMale Lewis ratsNovel rat modelNew animal modelCalcium/calmodulin-dependent protein kinase IIRelated neuropsychiatric disordersStreptococcal infectionLewis ratsAntibody depositionBasal gangliaCalmodulin-dependent protein kinase IIDopamine D1GAS antigensGlutamate levelsD2 receptors
2010
The Immunobiology of Tourette's Disorder, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus, and Related Disorders: A Way Forward
Murphy TK, Kurlan R, Leckman J. The Immunobiology of Tourette's Disorder, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus, and Related Disorders: A Way Forward. Journal Of Child And Adolescent Psychopharmacology 2010, 20: 317-331. PMID: 20807070, PMCID: PMC4003464, DOI: 10.1089/cap.2010.0043.Peer-Reviewed Original ResearchConceptsGroup A StreptococcusObsessive-compulsive disorderSydenham's choreaTourette's disorderRheumatic feverNeuropsychiatric symptomsPediatric Autoimmune Neuropsychiatric Disorder AssociatedPediatric autoimmune neuropsychiatric disordersA StreptococcusCommon anatomic areasNeuropsychiatric Disorder AssociatedAutoimmune neuropsychiatric disordersAttention-deficit/hyperactivity symptomsImmune dysfunctionUnknown etiologyBasal gangliaChildhood obsessive-compulsive disorderSudden onsetDisorders AssociatedMotor ticsVocal ticsTherapeutic aspectsThalamic sitesReference listsAnatomic areas
2009
Children with Tourette's Syndrome May Suffer Immunoglobulin A Dysgammaglobulinemia: Preliminary Report
Kawikova I, Grady BP, Tobiasova Z, Zhang Y, Vojdani A, Katsovich L, Richmand BJ, Park TW, Bothwell AL, Leckman JF. Children with Tourette's Syndrome May Suffer Immunoglobulin A Dysgammaglobulinemia: Preliminary Report. Biological Psychiatry 2009, 67: 679-683. PMID: 20006327, PMCID: PMC3974615, DOI: 10.1016/j.biopsych.2009.09.034.Peer-Reviewed Original ResearchConceptsUpper respiratory tract infectionEnzyme-linked immunosorbent assayControl subjectsOCD patientsSex-matched control subjectsRespiratory tract infectionsAntineuronal antibodiesSpecific IgATract infectionsHealthy ageSydenham's choreaTotal IgAMultiple sclerosisObsessive-compulsive disorderSpecific IgGTotal immunoglobulinImmune deficiencyPostinfectious autoimmunityTourette syndromePatientsImmunosorbent assayIgAChoreaSyndromeAntigen
2000
The Psychiatric Symptoms of Rheumatic Fever
Mercadante MT, Busatto GF, Lombroso PJ, Prado L, Rosário-Campos MC, do Valle R, Marques-Dias MJ, Kiss MH, Leckman JF, Miguel EC. The Psychiatric Symptoms of Rheumatic Fever. American Journal Of Psychiatry 2000, 157: 2036-2038. PMID: 11097972, DOI: 10.1176/appi.ajp.157.12.2036.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderRheumatic feverSydenham's choreaTic disordersHigh riskComparison groupFever groupMajor depressive disorderDeficit hyperactivity disorderObsessive-compulsive disorderDepressive disorderRisk factorsPsychiatric symptomsPsychiatric disordersChoreaFeverNeuropsychiatric disordersObsessive-compulsive symptomsRating ScaleHyperactivity disorderSymptomsDisordersADHD symptomsChildrenSemistructured interviews