2014
Pediatric Acute-Onset Neuropsychiatric Syndrome
Murphy TK, Gerardi DM, Leckman JF. Pediatric Acute-Onset Neuropsychiatric Syndrome. Psychiatric Clinics Of North America 2014, 37: 353-374. PMID: 25150567, DOI: 10.1016/j.psc.2014.06.001.Peer-Reviewed Original ResearchConceptsPediatric acute-onset neuropsychiatric syndromeNeuropsychiatric syndromePediatric autoimmune neuropsychiatric disordersAutoimmune neuropsychiatric disordersAutoimmune processClinical presentationObsessive-compulsive disorderNeuropsychiatric disordersSyndromeDisordersChildrenPathophysiologySymptoms
2007
The role of abnormal neural oscillations in the pathophysiology of co-occurring Tourette syndrome and attention-deficit/hyperactivity disorder
Sukhodolsky DG, Leckman JF, Rothenberger A, Scahill L. The role of abnormal neural oscillations in the pathophysiology of co-occurring Tourette syndrome and attention-deficit/hyperactivity disorder. European Child & Adolescent Psychiatry 2007, 16: 51-59. PMID: 17665283, DOI: 10.1007/s00787-007-1007-3.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderTourette syndromeAbnormal neural oscillationsOscillatory activityHyperactivity disorderAbnormal oscillatory activityThalamo-cortical circuitsSymptoms of ADHDNeural oscillationsNeural oscillatory activityBasal gangliaFunctional abnormalitiesNormal brainThalamocortical regionsThalamocortical oscillationsCortical regionsTransient hyperpolarizationPrefrontal cortexNeural activityNeural communicationPathophysiologyMotor controlSyndromeBrainDisordersFrontal dopaminergic abnormality in Tourette syndrome: A postmortem analysis
Yoon DY, Gause CD, Leckman JF, Singer HS. Frontal dopaminergic abnormality in Tourette syndrome: A postmortem analysis. Journal Of The Neurological Sciences 2007, 255: 50-56. PMID: 17337006, DOI: 10.1016/j.jns.2007.01.069.Peer-Reviewed Original ResearchConceptsTourette syndromeDopamine transporterReceptor densityPathophysiology of TSAlpha-adrenergic receptorsSex-matched controlsD2 receptor densityPostmortem brain tissueFrontal regionsDopaminergic dysfunctionNeurochemical abnormalitiesDopaminergic abnormalitiesNeurochemical markersTS patientsFrontal cortexSemiquantitative immunoblottingFrontal lobeBrain tissueTS subjectsTerminal markersOccipital regionAbnormalitiesVesicular dockingPathophysiologySyndrome
1990
Beyond the serotonin hypothesis: a role for dopamine in some forms of obsessive compulsive disorder?
Goodman WK, McDougle CJ, Price LH, Riddle MA, Pauls DL, Leckman JF. Beyond the serotonin hypothesis: a role for dopamine in some forms of obsessive compulsive disorder? The Journal Of Clinical Psychiatry 1990, 51 Suppl: 36-43; discussion 55-8. PMID: 2199433.Peer-Reviewed Original Research