2022
Neuroimmunoendocrinology of Tourette Syndrome
Martino D, Johnson I, Escobar A, Leckman J. Neuroimmunoendocrinology of Tourette Syndrome. 2022, 257-276. DOI: 10.1093/med/9780197543214.003.0016.Peer-Reviewed Original ResearchTourette syndromeImmune-modulatory interventionsImmune competent cellsGeneration of ticsCortico-subcortical circuitsNormal brain developmentNeuroimmune interactionsKey molecular pathwaysGut dysbiosisAllergic illnessHigh riskImmune pathwaysPostnatal lifeTherapeutic interventionsImmune primingImmune systemRelated disordersNeural circuitsBrain developmentNeurodevelopmental disordersDisordersMolecular pathwaysSyndromeDate summaryMolecular mechanisms
2019
What does immunology have to do with brain development and neuropsychiatric disorders?
Leckman J, Alvarenga P, Ravagnani B, Johnson I. What does immunology have to do with brain development and neuropsychiatric disorders? Revista De Medicina 2019, 98: 241-253. DOI: 10.11606/issn.1679-9836.v98i4p241-253.Peer-Reviewed Original ResearchImmune systemNormal brain developmentBrain developmentNeuropsychiatric disordersNeural circuitsGut-brain axisRelevant review articlesAutism spectrum disorderObsessive-compulsive disorderBody of evidenceImmune cellsMood disordersValid biomarkersSubset of individualsTourette syndromeNovel interventionsNeurodegenerative disordersPersonalized approachLiterature searchDisordersMultiple biological systemsPathobiologyNeural developmentTraditional literature searchIndividual microbiomes
1998
A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome
Peterson BS, Skudlarski P, Anderson AW, Zhang H, Gatenby JC, Lacadie CM, Leckman JF, Gore JC. A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome. JAMA Psychiatry 1998, 55: 326-333. PMID: 9554428, DOI: 10.1001/archpsyc.55.4.326.Peer-Reviewed Original ResearchConceptsTic suppressionTourette syndromeTic symptomsBasal gangliaPathogenesis of ticsVoluntary tic suppressionMagnetic resonance imaging studyResonance imaging studyFunctional magnetic resonance imaging studySubcortical neural circuitsFunctional magnetic resonance imagingMagnetic resonance imagingConnected cortical regionsRegional signal changesImpaired modulationSignal changesFunctional debilityNeuronal activityResonance imagingAdult subjectsImaging studiesCortical regionsNeuropsychiatric disordersNeural circuitsSyndrome