2019
Kundalini Yoga Meditation Versus the Relaxation Response Meditation for Treating Adults With Obsessive-Compulsive Disorder: A Randomized Clinical Trial
Shannahoff-Khalsa D, Fernandes RY, de B. Pereira C, March JS, Leckman JF, Golshan S, Vieira MSR, Polanczyk GV, Miguel EC, Shavitt RG. Kundalini Yoga Meditation Versus the Relaxation Response Meditation for Treating Adults With Obsessive-Compulsive Disorder: A Randomized Clinical Trial. Frontiers In Psychiatry 2019, 10: 793. PMID: 31780963, PMCID: PMC6859828, DOI: 10.3389/fpsyt.2019.00793.Peer-Reviewed Original ResearchY-BOCS scoresFirst-line therapyObsessive-compulsive disorderClinical trialsSecondary measuresY-BOCSShort Form-36 Health SurveyBaseline Y-BOCS scoresCompulsive ScaleGreater improvementRelative efficacyClinical Global ImpressionEffective treatment scheduleYale-Brown Obsessive Compulsive ScaleHigh psychosocial impairmentBeck Depression InventoryBeck Anxiety InventoryLife-long disorderObsessive Compulsive ScaleYale-Brown ObsessiveYoga meditationLine therapyPrimary outcomeTreat analysisReuptake inhibitors
2009
Dimensional predictors of response to SRI pharmacotherapy in obsessive–compulsive disorder
Landeros-Weisenberger A, Bloch MH, Kelmendi B, Wegner R, Nudel J, Dombrowski P, Pittenger C, Krystal JH, Goodman WK, Leckman JF, Coric V. Dimensional predictors of response to SRI pharmacotherapy in obsessive–compulsive disorder. Journal Of Affective Disorders 2009, 121: 175-179. PMID: 19577308, PMCID: PMC3974618, DOI: 10.1016/j.jad.2009.06.010.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSRI responseSymptom dimensionsOpen-label continuation phaseClinical Global Improvement ScaleGlobal Improvement ScaleCentral serotonin systemInitial positive responseYale-Brown ObsessiveContinuation phaseMinor symptomsOrdinal logistic regressionClinical trialsSerotonin systemTreatment responseSame patientImprovement ScaleSRI treatmentPatientsSignificant associationLogistic regressionCompulsive ScaleOCD patientsOCD subjectsSymptomsValidation of the University of São Paulo Sensory Phenomena Scale:Initial Psychometric Properties
Rosario MC, Prado HS, Borcato S, Diniz JB, Shavitt RG, Hounie AG, Mathis ME, Mastrorosa RS, Velloso P, Perin EA, Fossaluza V, Pereira CA, Geller D, Leckman J, Miguel E. Validation of the University of São Paulo Sensory Phenomena Scale:Initial Psychometric Properties. CNS Spectrums 2009, 14: 315-323. PMID: 19668122, DOI: 10.1017/s1092852900020319.Peer-Reviewed Original ResearchConceptsOpen clinical interviewClinical InterviewYale-Brown ObsessiveObsessive-compulsive disorderFourth Edition Axis I DisordersEarly-onset OCD patientsYale Global Tic Severity ScaleSensory phenomenaCompulsive ScaleOCD patientsOCD subjectsAxis I DisordersTic Severity ScaleSão Paulo Sensory Phenomena ScaleSignificant differencesBeck Depression InventoryBeck Anxiety InventorySeverity scoreI disordersInter-rater reliabilityInitial psychometric propertiesSeverity ScalePremonitory urgesPatientsDepression Inventory
2001
Adults With Early-Onset Obsessive-Compulsive Disorder
Rosario-Campos MC, Leckman JF, Mercadante MT, Shavitt RG, Prado HS, Sada P, Zamignani D, Miguel EC. Adults With Early-Onset Obsessive-Compulsive Disorder. American Journal Of Psychiatry 2001, 158: 1899-1903. PMID: 11691698, DOI: 10.1176/appi.ajp.158.11.1899.Peer-Reviewed Original ResearchConceptsSymptom onsetObsessive-compulsive disorderSelective serotonin reuptake inhibitorsOCD patientsSerotonin reuptake inhibitorsEarlier symptom onsetEarly-onset groupLater symptom onsetOnset obsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleComorbid tic disordersAdult OCD patientsObsessive Compulsive ScaleReuptake inhibitorsAdult outpatientsTic disordersTreatment outcomesOCD symptom onsetBimodal ageEarly onsetHeterogeneous disorderCompulsive ScaleDisordersAgePatients
1997
Obsessive-compulsive disorder with and without tics in an epidemiological sample of adolescents
Zohar AH, Pauls DL, Ratzoni G, Apter A, Dycian A, Binder M, King R, Leckman JF, Kron S, Cohen DJ. Obsessive-compulsive disorder with and without tics in an epidemiological sample of adolescents. American Journal Of Psychiatry 1997, 154: 274-276. PMID: 9016283, DOI: 10.1176/ajp.154.2.274.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderEpidemiological sampleObsessive-compulsive spectrum disordersYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleYale-Brown scaleSpectrum disorderSexual imagesCompulsive ScaleChild psychiatristsDiagnostic InterviewAdolescentsComorbid ticsSex differencesDisordersTourette syndromeInterviewsGilles deAdulthoodObsessionGirlsBoysScale
1994
"Just right" perceptions associated with compulsive behavior in Tourette's syndrome
Leckman JF, Walker DE, Goodman WK, Pauls DL, Cohen DJ. "Just right" perceptions associated with compulsive behavior in Tourette's syndrome. American Journal Of Psychiatry 1994, 151: 675-680. PMID: 8166308, DOI: 10.1176/ajp.151.5.675.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetAgedAwarenessBasal GangliaChildComorbidityCompulsive BehaviorCross-Sectional StudiesFemaleHumansMaleMiddle AgedObsessive BehaviorObsessive-Compulsive DisorderPerceptionPersonality InventoryPsychiatric Status Rating ScalesSensationSeverity of Illness IndexTourette SyndromeConceptsTic disordersObsessive-compulsive disorderTourette syndromeObsessive-compulsive symptomsCompulsive behaviorsCross-sectional studyYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleTic symptomsChronic disordersPhonic ticsChildhood onsetEpidemiological studiesSyndromeAdult subjectsBrain regionsSymptomsCompulsive ScaleDisordersSensorimotor informationSubjectsThree-quartersCompulsive actsPathobiologySeverity