Olanzapine for the Prevention of Postdischarge Nausea and Vomiting after Ambulatory Surgery: A Randomized Controlled Trial.
Hyman JB, Park C, Lin HM, Cole B, Rosen L, Fenske SS, Barr Grzesh RL, Blank SV, Polsky SB, Hartnett M, Taub PJ, Palvia V, DeMaria S, Ascher-Walsh C. Olanzapine for the Prevention of Postdischarge Nausea and Vomiting after Ambulatory Surgery: A Randomized Controlled Trial. Anesthesiology 2020, 132: 1419-1428. PMID: 32229754, DOI: 10.1097/aln.0000000000003286.Peer-Reviewed Original ResearchConceptsOlanzapine groupPlacebo groupAmbulatory surgeryPostdischarge nauseaSevere nauseaFemale patients 50 yearsStandard antiemetic prophylaxisPlacebo-controlled studyPlacebo-controlled trialPrimary composite outcomeSingle preoperative dosePatients 50 yearsRisk of nauseaAddition of olanzapineAntiemetic prophylaxisOlanzapine 10Preoperative doseComposite outcomeSecondary outcomesControlled TrialsPrimary outcomeOral olanzapineGeneral anesthesiaNauseaVomiting