Sex‐related differences in outcomes after coronary artery bypass surgery—A patient‐level pooled analysis of randomized controlled trials: rationale and study protocol
Gaudino M, Alexander JH, Egorova N, Kurlansky P, Lamy A, Bakaeen F, Hameed I, Di Franco A, Demetres M, Robinson NB, Chikwe J, Lawton JS, Devereaux PJ, Taggart DP, Flather M, Reents W, Boening A, Diegeler A, Girardi LN, Fremes SE, Benedetto U. Sex‐related differences in outcomes after coronary artery bypass surgery—A patient‐level pooled analysis of randomized controlled trials: rationale and study protocol. Journal Of Cardiac Surgery 2020, 35: 2754-2758. PMID: 32720394, DOI: 10.1111/jocs.14903.Peer-Reviewed Original ResearchConceptsSex-related differencesPooled analysisSystematic reviewPatient-level pooled analysisCoronary artery bypass surgeryMultiple arterial graftsArtery bypass surgeryCoronary artery bypassLong-term followSex-related outcomesTreatment effectsPreferred Reporting ItemsSystematic literature searchPeer-reviewed scientific journalsImpact of sexDifferential treatment effectsCABG studiesArtery bypassCause mortalityPrimary endpointBypass surgeryArterial graftsMyocardial infarctionStudy protocolProspective RegisterCharacteristics of Contemporary Randomized Clinical Trials and Their Association With the Trial Funding Source in Invasive Cardiovascular Interventions
Gaudino M, Hameed I, Rahouma M, Khan FM, Tam DY, Biondi-Zoccai G, Demetres M, Charlson ME, Ruel M, Crea F, Falk V, Girardi LN, Fremes S, Chikwe J. Characteristics of Contemporary Randomized Clinical Trials and Their Association With the Trial Funding Source in Invasive Cardiovascular Interventions. JAMA Internal Medicine 2020, 180: 993-1001. PMID: 32478821, PMCID: PMC7265124, DOI: 10.1001/jamainternmed.2020.1670.Peer-Reviewed Original ResearchConceptsPrimary end pointInvasive cardiovascular interventionsPrimary outcomeClinical trialsEnd pointCardiovascular interventionsSignificant differencesComposite primary end pointContemporary Randomized Clinical TrialsStructural interventional cardiologyTrial funding sourceCardiac surgical proceduresRandomized clinical trialsNumber of patientsCross-sectional studyExperimental interventionReporting of trialsTreatment effectsMedian sample sizeLarge treatment effectsContemporary RCTsGuideline recommendationsEvidence-based practiceTrial sponsorshipFavorable outcome