Featured Publications
Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data
Gaudino M, Di Franco A, Alexander JH, Bakaeen F, Egorova N, Kurlansky P, Boening A, Chikwe J, Demetres M, Devereaux PJ, Diegeler A, Dimagli A, Flather M, Hameed I, Lamy A, Lawton JS, Reents W, Robinson NB, Audisio K, Rahouma M, Serruys PW, Hara H, Taggart DP, Girardi LN, Fremes SE, Benedetto U. Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data. European Heart Journal 2021, 43: 18-28. PMID: 34338767, PMCID: PMC8851663, DOI: 10.1093/eurheartj/ehab504.Peer-Reviewed Original ResearchConceptsCoronary artery bypassIndividual patient dataMyocardial infarctionArtery bypassCause mortalityWorse outcomesMultiple arterial graftingPatient dataOff-pump surgeryOutcomes of womenCABG trialBaseline characteristicsPatients 75Secondary outcomesPrimary outcomeArterial graftingCox regressionPooled analysisSurgical techniqueHigh riskHigh incidenceSimilar mortalitySystematic reviewRisk adjustmentMortality
2023
Mild aortic insufficiency following transcatheter aortic valve replacement: A systematic review and meta‐analysis
Hameed I, Ahmed A, Kumar A, Li E, Candelario K, Khan S, Kannan A, Latif N, Amabile A, Geirsson A, Williams M. Mild aortic insufficiency following transcatheter aortic valve replacement: A systematic review and meta‐analysis. Catheterization And Cardiovascular Interventions 2023, 102: 166-175. PMID: 37172208, DOI: 10.1002/ccd.30674.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementMild aortic insufficiencyAortic insufficiencyAortic valve replacementPooled incidenceMidterm mortalityValve replacementIncidence of AIModerate-severe aortic insufficiencyHartung-Knapp adjustmentPooled incidence rateLong-term outcomesLonger life expectancyAI incidenceTAVR volumeSecondary outcomesPrimary outcomeYounger patientsFemale patientsMean agePooled analysisIncidence rateTAVR valvePatientsSystematic review
2021
Comparison of SYNTAX score strata effects of percutaneous and surgical revascularization trials: A meta-analysis
Gaudino M, Hameed I, Di Franco A, Naik A, Demetres M, Biondi-Zoccai G, Bangalore S. Comparison of SYNTAX score strata effects of percutaneous and surgical revascularization trials: A meta-analysis. Journal Of Thoracic And Cardiovascular Surgery 2021, 165: 1405-1413.e13. PMID: 34176619, PMCID: PMC8805094, DOI: 10.1016/j.jtcvs.2021.05.036.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionCoronary artery bypassIncidence rate ratiosCoronary interventionArtery bypassCerebrovascular eventsSYNTAX scoreMultivessel diseaseCause mortalityStatistical heterogeneityRate ratioSystematic reviewCardiac Surgery (SYNTAX) scoreSYNTAX score tertilesCochrane Library databasesMain analysisSignificant statistical heterogeneityRandom-effects modelRevascularization TrialScore tertilesSecondary outcomesSurgery scoreRisk stratificationLibrary databasesNonsignificant increase
2020
Treatment strategies in ischaemic left ventricular dysfunction: a network meta-analysis
Gaudino M, Hameed I, Khan FM, Tam DY, Rahouma M, Yongle R, Naik A, Di Franco A, Demetres M, Petrie MC, Jolicoeur EM, Girardi LN, Fremes SE. Treatment strategies in ischaemic left ventricular dysfunction: a network meta-analysis. European Journal Of Cardio-Thoracic Surgery 2020, 59: 293-301. PMID: 33085752, DOI: 10.1093/ejcts/ezaa319.Peer-Reviewed Original ResearchPercutaneous coronary interventionIschemic left ventricular systolic dysfunctionMedical therapyCardiac deathMyocardial infarctionRevascularization strategyHigh mortalityLeft ventricular systolic dysfunctionIschemic left ventricular dysfunctionLeft ventricular ejection fractionBest revascularization strategyLower cardiac deathOptimal revascularization strategyCoronary artery bypassVentricular systolic dysfunctionLeft ventricular dysfunctionVentricular ejection fractionDrug-eluting stentsRelative treatment effectsArtery bypassSystolic dysfunctionVentricular dysfunctionCoronary interventionSecondary outcomesEjection fractionAssociation of Radial Artery Graft vs Saphenous Vein Graft With Long-term Cardiovascular Outcomes Among Patients Undergoing Coronary Artery Bypass Grafting
Gaudino M, Benedetto U, Fremes S, Ballman K, Biondi-Zoccai G, Sedrakyan A, Nasso G, Raman J, Buxton B, Hayward PA, Moat N, Collins P, Webb C, Peric M, Petrovic I, Yoo KJ, Hameed I, Di Franco A, Moscarelli M, Speziale G, Puskas JD, Girardi LN, Hare DL, Taggart DP. Association of Radial Artery Graft vs Saphenous Vein Graft With Long-term Cardiovascular Outcomes Among Patients Undergoing Coronary Artery Bypass Grafting. JAMA 2020, 324: 179-187. PMID: 32662861, PMCID: PMC7361649, DOI: 10.1001/jama.2020.8228.Peer-Reviewed Original ResearchConceptsCoronary artery bypassSaphenous vein graftsComposite of deathRadial artery graftArtery bypassVein graftsRadial arteryMyocardial infarctionArtery graftCardiovascular outcomesClinical outcomesSaphenous veinLong-term cardiovascular outcomesPatient-level pooled analysisCoronary Artery Bypass GraftingArtery Bypass GraftingIndividual participant dataBypass GraftingAdult patientsComposite outcomeSecondary outcomesPrimary outcomeRandomized trialsPooled analysisObservational studyOpen Repair of Descending Thoracic and Thoracoabdominal Aortic Aneurysms: A Meta-Analysis
Khan FM, Naik A, Hameed I, Robinson NB, Spadaccio C, Rahouma M, Yongle R, Demetres M, Chen H, Chang M, Girardi LN, Gaudino M. Open Repair of Descending Thoracic and Thoracoabdominal Aortic Aneurysms: A Meta-Analysis. The Annals Of Thoracic Surgery 2020, 110: 1941-1949. PMID: 32504596, DOI: 10.1016/j.athoracsur.2020.04.069.Peer-Reviewed Original ResearchConceptsThoracoabdominal aortic aneurysmsCerebrospinal fluid drainsOpen repairOperative mortalitySpinal cord injuryAortic aneurysmLate mortalityRespiratory failureRenal failureCord injuryMyocardial infarctionGeneric inverse variance methodFluid drainsHigh operative mortalityLow operative mortalityInverse variance methodThoracic aortic aneurysmSystematic literature searchPostoperative strokeOperative deathsPerioperative complicationsPostoperative outcomesSecondary outcomesPrimary outcomePooled rateSpinal cord injury after open and endovascular repair of descending thoracic and thoracoabdominal aortic aneurysms: A meta-analysis
Gaudino M, Khan FM, Rahouma M, Naik A, Hameed I, Spadaccio C, Robinson NB, Ruan Y, Demetres M, Oakley CT, Gambardella I, Iannacone EM, Lau C, Girardi LN. Spinal cord injury after open and endovascular repair of descending thoracic and thoracoabdominal aortic aneurysms: A meta-analysis. Journal Of Thoracic And Cardiovascular Surgery 2020, 163: 552-564. PMID: 32561196, DOI: 10.1016/j.jtcvs.2020.04.126.Peer-Reviewed Original ResearchConceptsThoracoabdominal aortic aneurysmsPooled rateTAAA repairOperative mortalityEndovascular repairAneurysm repairAortic aneurysmSpinal cord injury ratesGeneric inverse variance methodCrawford extent ILong-term mortalityEndovascular aneurysm repairSpinal cord injuryInverse variance methodDrain-related complicationsSystematic literature searchPostoperative strokeLate mortalitySecondary outcomesOpen repairPrimary outcomeRelated complicationsThoracic aneurysmCord injuryInjury ratesComparison of the effects of hemodialysis and hemodiafiltration on left ventricular hypertrophy in end‐stage renal disease patients: A systematic review and meta‐analysis
Hameed I, Gaudino M, Naik A, Rahouma M, Robinson NB, Ruan Y, Demetres M, Bossola M. Comparison of the effects of hemodialysis and hemodiafiltration on left ventricular hypertrophy in end‐stage renal disease patients: A systematic review and meta‐analysis. Seminars In Dialysis 2020, 33: 120-126. PMID: 32159258, DOI: 10.1111/sdi.12864.Peer-Reviewed Original ResearchConceptsLeft ventricular mass indexEjection fractionMean differenceVentricular hypertrophySubgroup analysisConventional hemodialysisEnd-stage renal disease patientsLonger dialysis durationVentricular mass indexPooled mean differenceRenal disease patientsEffect of hemodialysisLeft ventricular hypertrophySystematic literature searchDialysis durationPrimary outcomeSecondary outcomesMass indexDisease patientsHemodialysisSystematic reviewHemodiafiltrationLowest mean differenceLiterature searchPatients
2019
Effect of atrial pacing on post-operative atrial fibrillation following coronary artery bypass grafting: Pairwise and network meta-analyses
Ruan Y, Robinson NB, Naik A, Silva M, Hameed I, Rahouma M, Oakley C, Di Franco A, Zamvar V, Girardi LN, Gaudino M. Effect of atrial pacing on post-operative atrial fibrillation following coronary artery bypass grafting: Pairwise and network meta-analyses. International Journal Of Cardiology 2019, 302: 103-107. PMID: 31837901, DOI: 10.1016/j.ijcard.2019.12.009.Peer-Reviewed Original ResearchConceptsPost-operative atrial fibrillationCoronary artery bypassBiA pacingAtrial pacingArtery bypassSecondary outcomesAtrial fibrillationIncidence of POAFGeneric inverse variance methodRight atrial pacingInverse variance methodLargest risk reductionSystematic literature searchPOAF incidenceOperative mortalityPostoperative bleedingPrimary outcomePacing modalitiesClinical trialsLower incidencePacingLiterature searchIncidenceFibrillationRisk reductionThree‐Dimensional Echocardiography for Transcatheter Aortic Valve Replacement Sizing: A Systematic Review and Meta‐Analysis
Rong LQ, Hameed I, Salemi A, Rahouma M, Khan FM, Wijeysundera HC, Angiolillo DJ, Shore‐Lesserson L, Biondi‐Zoccai G, Girardi LN, Fremes SE, Gaudino M. Three‐Dimensional Echocardiography for Transcatheter Aortic Valve Replacement Sizing: A Systematic Review and Meta‐Analysis. Journal Of The American Heart Association 2019, 8: e013463. PMID: 31549579, PMCID: PMC6806040, DOI: 10.1161/jaha.119.013463.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisEchocardiography, Three-DimensionalFemaleHeart Valve ProsthesisHumansMaleMultidetector Computed TomographyObserver VariationPredictive Value of TestsProsthesis DesignRadiographic Image Interpretation, Computer-AssistedReproducibility of ResultsSeverity of Illness IndexTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve replacementParavalvular aortic regurgitationAortic regurgitationPrimary outcomeAnnular diameterAnnular perimeterTranscatheter aortic valve replacement sizingSystematic reviewSevere symptomatic aortic stenosisVentricular outflow tract areaBackground Transcatheter aortic valve replacementMean annular diameterOutflow tract areaPre-TAVR planningSymptomatic aortic stenosisAortic valve replacementStandard of careRandom-effects modelSystematic literature searchAnnular areaThree-dimensional echocardiographyContrast exposureRenal dysfunctionAortic stenosisSecondary outcomesCharacteristics and anatomic distribution of early vs late stroke after cardiac surgery
Ivascu NS, Khan FM, Rahouma M, Hameed I, Abouarab A, Segal AZ, Gaudino MFL, Girardi LN. Characteristics and anatomic distribution of early vs late stroke after cardiac surgery. Journal Of Cardiac Surgery 2019, 34: 684-689. PMID: 31212394, DOI: 10.1111/jocs.14121.Peer-Reviewed Original ResearchConceptsLate strokeOperative mortalityCardiac surgeryEarly strokePerioperative strokeOpen cardiac surgeryTime of presentationOpen heart surgeryImpact of strokeWeill Cornell MedicinePerioperative variablesAdult patientsAnterior circulationEmbolic eventsSecondary outcomesCardiopulmonary bypassLikely etiologyAnatomic distributionHeart surgeryRisk factorsAnatomic locationHigh incidencePatientsSurgeryStrokeCerebral protection strategies in aortic arch surgery: A network meta-analysis
Hameed I, Rahouma M, Khan FM, Wingo M, Demetres M, Tam DY, Lau C, Iannacone EM, Di Franco A, Palaniappan A, Anderson H, Fremes SE, Girardi LN, Gaudino M. Cerebral protection strategies in aortic arch surgery: A network meta-analysis. Journal Of Thoracic And Cardiovascular Surgery 2019, 159: 18-31. PMID: 30902473, DOI: 10.1016/j.jtcvs.2019.02.045.Peer-Reviewed Original ResearchDeep hypothermic circulatory arrestAntegrade cerebral perfusionRetrograde cerebral perfusionHypothermic circulatory arrestAortic arch surgeryCerebral perfusionCirculatory arrestArch surgeryPostoperative strokeSecondary outcomesPrimary outcomeBilateral antegrade cerebral perfusionGeneric inverse variance methodCerebral protection strategiesCirculatory arrest durationTransient neurologic deficitsOperative mortality rateBetter postoperative outcomesInverse variance methodSystematic literature searchCerebral protectionOperative mortalityRespiratory complicationsNeurologic deficitsPostoperative outcomes