2020
Robustness of the Comparative Observational Evidence Supporting Class I and II Cardiac Surgery Procedures
Gaudino M, Hameed I, Robinson NB, Naik A, Weidenmann V, Ruan Y, Tam D, Girardi LN, Fremes S. Robustness of the Comparative Observational Evidence Supporting Class I and II Cardiac Surgery Procedures. Journal Of The American Heart Association 2020, 9: e016964. PMID: 32815427, PMCID: PMC7660761, DOI: 10.1161/jaha.120.016964.Peer-Reviewed Original ResearchConceptsBilateral internal thoracic arteryValve-sparing root replacementSingle internal thoracic arteryInternal thoracic arteryThoracic arteryBentall procedureRoot replacementMV repairObservational studyClass IEffect estimatesCardiac surgery proceduresImproved clinical outcomesMitral valve repairUnmeasured confoundingEffect sizeObserved effect estimatesMV replacementSurgery guidelinesClinical outcomesValve repairRisk ratioArterySurgery proceduresObserved associationsAssociation of Radial Artery Graft vs Saphenous Vein Graft With Long-term Cardiovascular Outcomes Among Patients Undergoing Coronary Artery Bypass Grafting
Gaudino M, Benedetto U, Fremes S, Ballman K, Biondi-Zoccai G, Sedrakyan A, Nasso G, Raman J, Buxton B, Hayward PA, Moat N, Collins P, Webb C, Peric M, Petrovic I, Yoo KJ, Hameed I, Di Franco A, Moscarelli M, Speziale G, Puskas JD, Girardi LN, Hare DL, Taggart DP. Association of Radial Artery Graft vs Saphenous Vein Graft With Long-term Cardiovascular Outcomes Among Patients Undergoing Coronary Artery Bypass Grafting. JAMA 2020, 324: 179-187. PMID: 32662861, PMCID: PMC7361649, DOI: 10.1001/jama.2020.8228.Peer-Reviewed Original ResearchConceptsCoronary artery bypassSaphenous vein graftsComposite of deathRadial artery graftArtery bypassVein graftsRadial arteryMyocardial infarctionArtery graftCardiovascular outcomesClinical outcomesSaphenous veinLong-term cardiovascular outcomesPatient-level pooled analysisCoronary Artery Bypass GraftingArtery Bypass GraftingIndividual participant dataBypass GraftingAdult patientsComposite outcomeSecondary outcomesPrimary outcomeRandomized trialsPooled analysisObservational study
2019
Disagreement Between Randomized and Observational Evidence on the Use of Bilateral Internal Thoracic Artery Grafting: A Meta‐Analytic Approach
Gaudino M, Rahouma M, Hameed I, Khan FM, Taggart DP, Flather M, Biondi‐Zoccai G, Fremes SE. Disagreement Between Randomized and Observational Evidence on the Use of Bilateral Internal Thoracic Artery Grafting: A Meta‐Analytic Approach. Journal Of The American Heart Association 2019, 8: e014638. PMID: 31752642, PMCID: PMC6912987, DOI: 10.1161/jaha.119.014638.Peer-Reviewed Original ResearchConceptsInternal thoracic arteryObservational studyThoracic arterySurvival dataBilateral Internal Thoracic Artery GraftingBilateral internal thoracic artery groupBilateral internal thoracic arteryCox regression hazardPropensity-matched studyLong-term outcomesMost observational studiesArtery GraftingArtery groupImproved survivalControl armImproved outcomesControl groupSurvival curvesArteryBeneficial effectsMeta-analytic approachSurvivalPatientsExperimental groupOutcomesThe RADial artery International ALliance (RADIAL) extended follow-up study: rationale and study protocol
Gaudino M, Benedetto U, Fremes S, Ballman K, Biondi-Zoccai G, Sedrakyan A, Nasso G, Raman J, Buxton B, Hayward PA, Moat N, Collins P, Webb C, Peric M, Petrovic I, Yoo KJ, Hameed I, Di Franco A, Moscarelli M, Speziale G, Girardi LN, Hare DL, Taggart DP, Investigators R. The RADial artery International ALliance (RADIAL) extended follow-up study: rationale and study protocol. European Journal Of Cardio-Thoracic Surgery 2019, 56: 1025-1030. PMID: 31535147, DOI: 10.1093/ejcts/ezz247.Peer-Reviewed Original ResearchConceptsPatency ratesSaphenous veinGood mid-term patency ratesMid-term patency ratesCoronary artery bypass surgeryRadial artery graftArtery bypass surgeryEvent-free survivalSaphenous vein graftsLong-term outcomesImproved patency ratesRA armArtery graftPostoperative yearRepeat revascularizationBypass surgeryCardiac eventsVein graftsClinical correlatesStudy protocolObservational studyRole of RasGraftTrialsSurvival