2024
Dedifferentiated early postnatal lung myofibroblasts redifferentiate in adult disease
Chandran R, Adams T, Kabir I, Gallardo-Vara E, Kaminski N, Gomperts B, Greif D. Dedifferentiated early postnatal lung myofibroblasts redifferentiate in adult disease. Frontiers In Cell And Developmental Biology 2024, 12: 1335061. PMID: 38572485, PMCID: PMC10987733, DOI: 10.3389/fcell.2024.1335061.Peer-Reviewed Original ResearchRNA sequencing analysisSMA+ myofibroblastsGene expression profilesLung myofibroblastsAdult lungSequence analysisResponse to lung injurySingle cell RNA sequencing analysisTissue remodeling genesSmooth muscle cell markersLung to hypoxiaExpression profilesRemodeling genesMuscle cell markersResponse to injuryCell typesSMA cellsLineage tracingLung injuryCell markersLineagesGenesAdult diseaseDrug bleomycinLung surface area
2016
Liver serine palmitoyltransferase activity deficiency in early life impairs adherens junctions and promotes tumorigenesis
Li Z, Kabir I, Jiang H, Zhou H, Libien J, Zeng J, Stanek A, Ou P, Li KR, Zhang S, Bui HH, Kuo M, Park T, Kim B, Worgall TS, Huan C, Jiang X. Liver serine palmitoyltransferase activity deficiency in early life impairs adherens junctions and promotes tumorigenesis. Hepatology 2016, 64: 2089-2102. PMID: 27642075, PMCID: PMC5115983, DOI: 10.1002/hep.28845.Peer-Reviewed Original ResearchConceptsAdherens junctionsSerine palmitoyltransferaseHepatocyte polaritySubunit 2 geneCanonical Wnt pathwaySphingolipid biosynthesisPlasma membraneKey enzymeMajor proteinsWnt pathwayRecombination approachHepatocyte plasma membraneCellular distributionΒ-cateninTumorigenesisCadherin phosphorylationSphingomyelin levelsActivity deficiencyCentral componentPalmitoyltransferaseMembraneCadherinBiosynthesisLiver regenerationGenes