2021
Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis
Chandran RR, Xie Y, Gallardo-Vara E, Adams T, Garcia-Milian R, Kabir I, Sheikh AQ, Kaminski N, Martin KA, Herzog EL, Greif DM. Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis. Nature Communications 2021, 12: 7179. PMID: 34893592, PMCID: PMC8664937, DOI: 10.1038/s41467-021-27499-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationDisease Models, AnimalDown-RegulationExtracellular MatrixFemaleFibroblastsFibrosisHumansKruppel-Like Factor 4LungLung InjuryMaleMesenchymal Stem CellsMiceMice, Inbred C57BLMyofibroblastsReceptor, Platelet-Derived Growth Factor betaRespiratory Tract DiseasesSignal TransductionTransforming Growth Factor betaConceptsMesenchymal cell typesPlatelet-derived growth factor receptorSmooth muscle actinLung fibrosisKruppel-like factor 4Forkhead box M1Growth factor receptorCell transitionCell typesExtracellular matrixDistinct rolesKLF4Box M1C chemokine ligandMesenchymal cell subtypesFactor receptorPro-fibrotic effectsFactor 4PDGFRMesenchymeCellsMacrophage accumulationKLF4 levelsChemokine ligandLung fibrogenesis
2015
All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity[S]
Ding T, Kabir I, Li Y, Lou C, Yazdanyar A, Xu J, Dong J, Zhou H, Park T, Boutjdir M, Li Z, Jiang XC. All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity[S]. Journal Of Lipid Research 2015, 56: 537-545. PMID: 25605874, PMCID: PMC4340302, DOI: 10.1194/jlr.m054627.Peer-Reviewed Original ResearchConceptsCeramide phosphoethanolamineCPE levelsSynthase activityObvious phenotypic alterationsSynthase gene familySf9 insect cellsQuantitative MS analysisGene familyCeramide homeostasisInsect cellsCritical regulatorNBD-ceramideSMS2 activityPhenotypic alterationsSMS1SMS1 deficiencySphingolipid levelsSMS2Ceramide levelsCell functionKO miceCell studiesMS analysisFamily membersCells