1998
Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats
Jacobs H, Bogue C, Pinter E, Wilson C, Warshaw J, Gross I. Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats. Pediatric Research 1998, 44: 99-104. PMID: 9667378, DOI: 10.1203/00006450-199807000-00016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsButyratesButyric AcidDiabetes Mellitus, ExperimentalEmbryonic and Fetal DevelopmentFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxGestational AgeHistone Deacetylase InhibitorsLungOrgan Culture TechniquesPregnancyPregnancy in DiabeticsRatsRats, Sprague-DawleyRNA, MessengerTranscription, GeneticConceptsLung developmentLung explantsSurfactant apoproteinExperimental animalsLung mRNA levelsElevated levelsEffect of diabetesFetal rat lung explantsLungs of fetusesRat lung explantsEffect of butyrateAntenatal exposureMaternal diabetesMetabolic abnormalitiesStreptozotocin treatmentLower incidenceNormal ratsDiabetesDexamethasoneLevel of expressionRatsTreatment of explantsSodium butyrateMRNA levelsAlters expression
1996
Retinoic acid increases surfactant protein mRNA in fetal rat lung in culture
Bogue CW, Jacobs HC, Dynia DW, Wilson CM, Gross I. Retinoic acid increases surfactant protein mRNA in fetal rat lung in culture. American Journal Of Physiology 1996, 271: l862-l868. PMID: 8944731, DOI: 10.1152/ajplung.1996.271.5.l862.Peer-Reviewed Original Research
1994
Butyrate modulates surfactant protein mRNA in fetal rat lung by altering mRNA transcription and stability
Peterec S, Nichols K, Dynia D, Wilson C, Gross I. Butyrate modulates surfactant protein mRNA in fetal rat lung by altering mRNA transcription and stability. American Journal Of Physiology 1994, 267: l9-l15. PMID: 8048547, DOI: 10.1152/ajplung.1994.267.1.l9.Peer-Reviewed Original ResearchConceptsFetal rat lungButyric acid analogueMRNA concentrationsRat lungNa-butyrateSP-A levelsDiabetic pregnanciesMaternal diabetesPulmonary maturationLung maturationMRNA transcriptionBiphasic effectSurfactant protein mRNAsProtein mRNASP-B mRNAAcid analoguesButyrate treatmentLungExposure of explantsFetusesInitial decreaseMRNAGene expressionButyrateMaturationIdentification of Hox genes in newborn lung and effects of gestational age and retinoic acid on their expression
Bogue CW, Gross I, Vasavada H, Dynia DW, Wilson CM, Jacobs HC. Identification of Hox genes in newborn lung and effects of gestational age and retinoic acid on their expression. American Journal Of Physiology 1994, 266: l448-l454. PMID: 7909996, DOI: 10.1152/ajplung.1994.266.4.l448.Peer-Reviewed Original ResearchConceptsGestational ageReverse transcription-polymerase chain reactionNewborn mouse lungRat lung explantsMouse lungRetinoic acidMRNA levelsLung explantsRat lungFetal rat lung explantsEffects of RATranscription-polymerase chain reactionM retinoic acidTime-dependent increaseNewborn lungRA treatmentFetal miceLungRodent lungsSignificant doseHigher mRNA levelsFetal tissuesDivergent homeobox gene HexGene expressionPattern of expression
1992
Surfactant protein C: hormonal control of SP-C mRNA levels in vitro
Veletza S, Nichols K, Gross I, Lu H, Dynia D, Floros J. Surfactant protein C: hormonal control of SP-C mRNA levels in vitro. American Journal Of Physiology 1992, 262: l684-l687. PMID: 1319687, DOI: 10.1152/ajplung.1992.262.6.l684.Peer-Reviewed Original ResearchMeSH Keywords8-Bromo Cyclic Adenosine MonophosphateAnalysis of VarianceAnimalsBase SequenceBucladesineCell NucleusCloning, MolecularDexamethasoneFetusGene LibraryHumansKineticsLungMolecular Sequence DataOligonucleotide ProbesOrgan Culture TechniquesProteolipidsPulmonary SurfactantsRatsRNA, MessengerTranscription, GeneticConceptsSP-C mRNA levelsSP-C mRNAMRNA levelsHormonal regulationSurfactant protein CSurfactant protein mRNAsTranscriptional assaysThyroid hormone T3Transcriptional stepNorthern blotCDNA probeProtein mRNACyclic monophosphateCAMP analogSpHormone T3Hormonal controlMRNASurfactant proteinsRegulationLung explantsDose-dependent increaseRat lung explantsExplantsProtein C
1991
Comparison of theMaclura pomifera lectin-binding glycoprotein in late fetal and adult rat lung
Kresch M, Lwebuga-Mukasa J, Wilson C, Gross I. Comparison of theMaclura pomifera lectin-binding glycoprotein in late fetal and adult rat lung. Lung 1991, 169: 139-151. PMID: 1895777, DOI: 10.1007/bf02714150.Peer-Reviewed Original ResearchConceptsCell membraneMaclura pomifera agglutininTwo-dimensional peptide mapsSame apparent molecular weightAdult lungCell surface glycoproteinApparent molecular weightDodecylsulfate-polyacrylamide gel electrophoresisSodium dodecylsulfate-polyacrylamide gel electrophoresisAdult proteinKD proteinResidues of glycoproteinsAmino acid analysisLung cell membranesPeptide mapsApical surfaceHormonal Effects on the Surfactant Protein B (SP-B) mRNA in Cultured Fetal Rat Lung
Floros J, Gross I, Nichols K, Veletza S, Dynia D, Lu H, Wilson C, Peterec S. Hormonal Effects on the Surfactant Protein B (SP-B) mRNA in Cultured Fetal Rat Lung. American Journal Of Respiratory Cell And Molecular Biology 1991, 4: 449-454. PMID: 1850607, DOI: 10.1165/ajrcmb/4.5.449.Peer-Reviewed Original Research
1990
Regulation of surfactant protein A mRNA by hormones and butyrate in cultured fetal rat lung
Nichols K, Floros J, Dynia D, Veletza S, Wilson C, Gross I. Regulation of surfactant protein A mRNA by hormones and butyrate in cultured fetal rat lung. American Journal Of Physiology 1990, 259: l488-l495. PMID: 2175559, DOI: 10.1152/ajplung.1990.259.6.l488.Peer-Reviewed Original Research8-Bromo Cyclic Adenosine MonophosphateAnimalsBucladesineButyratesButyric AcidDexamethasoneFetusGene Expression RegulationGlycoproteinsLungOrgan Culture TechniquesPhospholipidsProteolipidsPulmonary Surfactant-Associated Protein APulmonary Surfactant-Associated ProteinsPulmonary SurfactantsRatsRNA ProbesRNA, MessengerTriiodothyronine
1989
Initiation of Fetal Rat Lung Phospholipid and Surfactant-Associated Protein A mRNA Synthesis
Gross I, Wilson C, Floros J, Dynia D. Initiation of Fetal Rat Lung Phospholipid and Surfactant-Associated Protein A mRNA Synthesis. Pediatric Research 1989, 25: 239-244. PMID: 2704589, DOI: 10.1203/00006450-198903000-00004.Peer-Reviewed Original ResearchConceptsRU 486Lung tissueGlucocorticoid agonist activityRat lung phospholipidsAntagonist RU 486Steroid antagonist RU 486Surfactant-associated protein AFetal rat lungGlucocorticoid antagonistSurfactant associated proteinsLung phospholipidsSurfactant-associated proteinsFetal lungRat lungSurfactant productionComponents of surfactantSignificant increaseGlucocorticoidsLungControl explantsSpecific cytoplasmicPhosphatidylcholine synthesisSame extentPhospholipid productionTissue
1988
Activities of enzymes of phospholipid and fatty acid synthesis in fetal and adult rat type II pneumocytes
Kresch M, Smart D, Wilson C, Gross I, Rooney S. Activities of enzymes of phospholipid and fatty acid synthesis in fetal and adult rat type II pneumocytes. Biochimica Et Biophysica Acta 1988, 962: 173-177. PMID: 2844273, DOI: 10.1016/0005-2760(88)90156-7.Peer-Reviewed Original Research
1987
Culture of differentiated and undifferentiated type II cells from fetal rat lung
Kresch M, Dynia D, Gross I. Culture of differentiated and undifferentiated type II cells from fetal rat lung. Biochimica Et Biophysica Acta 1987, 930: 19-32. PMID: 3620509, DOI: 10.1016/0167-4889(87)90151-0.Peer-Reviewed Original Research
1986
Glucocorticoid stimulation of choline-phosphate cytidylyltransferase activity in fetal rat lung: Receptor-response relationships
Rooney S, Dynia D, Smart D, Chu A, Ingleson L, Wilson C, Gross I. Glucocorticoid stimulation of choline-phosphate cytidylyltransferase activity in fetal rat lung: Receptor-response relationships. Biochimica Et Biophysica Acta 1986, 888: 208-216. PMID: 3017448, DOI: 10.1016/0167-4889(86)90023-6.Peer-Reviewed Original ResearchConceptsEffect of dexamethasoneDexamethasone bindingCholine-phosphate cytidylyltransferase activitySpecific dexamethasone bindingFetal lung maturationFetal rat lung explantsCholine-phosphate cytidylyltransferaseSpecific nuclear bindingCytidylyltransferase activityRat lung explantsReceptor-mediated processSupernatant fractionFetal rat lungDose-response curveDexamethasone-treated culturesLung maturationGlucocorticoid bindingGlucocorticoid actionDe novo phosphatidylcholine synthesisLung explantsRat lungDexamethasoneGlucocorticoid stimulationStimulatory effectCholine incorporation
1985
Influence of Theophylline on Fetal Rat Lung Phosphatidylcholine Synthesis in vivo
Moya F, Gross I. Influence of Theophylline on Fetal Rat Lung Phosphatidylcholine Synthesis in vivo. Neonatology 1985, 8: 9-16. PMID: 3987490, DOI: 10.1159/000457017.Peer-Reviewed Original ResearchConceptsSerum levelsFetal lung surfactant productionInfluence of theophyllineLung tissue concentrationsElevated serum levelsDoses of theophyllineLung surfactant productionPhosphatidylcholine synthesisMaternal ratioPregnant ratsIntraperitoneal administrationTissue concentrationsRate of incorporationSurfactant productionTheophyllineVivoFetusesRatsAdministrationDosesDelayed Pulmonary Maturation in the Fetus of the Streptozotocin-Diabetic Rat
Gewolb I, Rooney S, Barrett C, Ingleson L, Light D, Wilson C, Smith G, Gross I, Warshaw J. Delayed Pulmonary Maturation in the Fetus of the Streptozotocin-Diabetic Rat. Experimental Lung Research 1985, 8: 141-151. PMID: 4029093, DOI: 10.3109/01902148509057518.Peer-Reviewed Original ResearchConceptsStreptozotocin-diabetic ratsDiabetic groupPulmonary maturationDay 21Lung developmentDelayed pulmonary maturationAlveolar lining cellsEffects of hyperglycemiaFetal lung developmentDays of gestationObserved developmental delayType II cellsControl lungsMaturational delayCholinephosphate cytidylyltransferase activityIntravenous injectionRat gestationDiabetic fetusesLining cellsDay 22Day 20FetusesActivity of enzymesDevelopmental delayDecreased number
1984
Corticosteroid binding by fetal rat and rabbit lung in organ culture
Ballard P, Ballard R, Gonzales L, Huemmelink R, Wilson C, Gross I. Corticosteroid binding by fetal rat and rabbit lung in organ culture. The Journal Of Steroid Biochemistry And Molecular Biology 1984, 21: 117-126. PMID: 6482426, DOI: 10.1016/0022-4731(84)90371-6.Peer-Reviewed Original ResearchConceptsRabbit lungsFetal ratsDexamethasone binding capacityConcentrations of dexamethasoneFetal lung cellsHalf-maximal stimulationGlucocorticoid effectsPhosphatidylcholine synthesisActive glucocorticoidsCorticosteroid metabolismDexamethasone bindingGlucocorticoid actionReceptor concentrationRabbit fetusesReceptor capacityFetal developmentRat lungLungBinding capacityFemale rabbitsLung cellsDexamethasoneCholine incorporationPhysiologic activityPrior exposure
1983
Fetal rat lung maturation: initiation and modulation
Gross I, Wilson C. Fetal rat lung maturation: initiation and modulation. Journal Of Applied Physiology 1983, 55: 1725-1732. PMID: 6662763, DOI: 10.1152/jappl.1983.55.6.1725.Peer-Reviewed Original ResearchConceptsFetal lung maturationGestational ageLung maturationCholine incorporationEquivalent gestational ageFetal rat lungGlucocorticoid bindingDays gestationLung tissueFetal lungRat lungBiochemical markersLung developmentMorphological maturationDSPC contentMesenchymal tissueMaturational processesMarked increaseHormoneSimilar increaseLungLate modulationPhosphatidylcholine synthesisAgeMaturation
1982
Fetal lung in organ culture. IV. Supra-additive hormone interactions
Gross I, Wilson C. Fetal lung in organ culture. IV. Supra-additive hormone interactions. Journal Of Applied Physiology 1982, 52: 1420-1425. PMID: 6286561, DOI: 10.1152/jappl.1982.52.6.1420.Peer-Reviewed Original ResearchConceptsFetal lung maturationLung maturationSupra-additive interactionOrgan cultureCombination of dexamethasoneRate of incorporationFetal rat lungVivo animal studiesHormone administrationFetal lungAnimal studiesRat lungSupra-additive stimulationThyroid hormonesNM dexamethasoneDexamethasone concentrationsMaximal stimulationLungDexamethasoneNM triiodothyroninePulmonary surfactantSignificant increaseStimulationPrecursor incorporationCyclic monophosphate
1981
Organotypic Culture of Fetal Rat Lung: Evaluation and Comparison with Organ Culture1–3
Gross I, Freedman R, Wilson C, Lindsey S. Organotypic Culture of Fetal Rat Lung: Evaluation and Comparison with Organ Culture1–3. American Journal Of Respiratory And Critical Care Medicine 1981, 123: 313-9. PMID: 7224342, DOI: 10.1164/arrd.1981.123.3.313.Peer-Reviewed Original Research
1980
Insulin antagonism of dexamethasone-induced stimulation of cholinephosphate cytidylyltransferase in fetal rat lung in organ culture
Rooney S, Ingleson L, Wilson C, Gross I. Insulin antagonism of dexamethasone-induced stimulation of cholinephosphate cytidylyltransferase in fetal rat lung in organ culture. Lung 1980, 158: 151-155. PMID: 6255261, DOI: 10.1007/bf02713717.Peer-Reviewed Original ResearchThe Influence of Hormones on the Biochemical Development of Fetal Rat Lung in Organ Culture. II. Insulin
Gross I, Walker Smith G, Wilson C, Maniscalco W, Ingleson L, Brehier A, Rooney S. The Influence of Hormones on the Biochemical Development of Fetal Rat Lung in Organ Culture. II. Insulin. Pediatric Research 1980, 14: 834-838. PMID: 6995921, DOI: 10.1203/00006450-198006000-00012.Peer-Reviewed Original ResearchConceptsFetal rat lungRat lungCholine incorporationSignificant decreasePhospholipid fractionInfluence of insulinEffect of insulinInfluence of hormonesPercentage of radioactivityType II cellsLung cell growthLung cell differentiationLung maturationOrgan culture systemInsulin treatmentMorphologic evidencePhospholipid radioactivityInsulinMorphologic maturationSurfactant phospholipidsGlycogen contentII cellsOrgan cultureBiochemical developmentLamellar bodies