2018
Dstac is required for normal circadian activity rhythms in Drosophila
Hsu IU, Linsley JW, Varineau JE, Shafer OT, Kuwada JY. Dstac is required for normal circadian activity rhythms in Drosophila. Chronobiology International 2018, 35: 1016-1026. PMID: 29621409, PMCID: PMC6103890, DOI: 10.1080/07420528.2018.1454937.Peer-Reviewed Original ResearchConceptsPigment Dispersing FactorS-LNSmall ventrolateral neuronsBrain of DrosophilaL-type voltage-gated CaCircadian activityNovel genesAdaptor proteinCircadian locomotionVoltage-gated CaActivity rhythmsDrosophilaDmca1DGenesVentrolateral neuronsCircadian activity rhythmsVertebratesSTAC3ProteinBindsCACHActivity
2016
Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3
Linsley JW, Hsu IU, Groom L, Yarotskyy V, Lavorato M, Horstick EJ, Linsley D, Wang W, Franzini-Armstrong C, Dirksen RT, Kuwada JY. Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 114: e228-e236. PMID: 28003463, PMCID: PMC5240691, DOI: 10.1073/pnas.1619238114.Peer-Reviewed Original ResearchConceptsEC couplingDihydropyridine receptorNative American myopathySarcoplasmic reticulumExcitation-contraction couplingSkeletal muscle contractionVoltage-sensing dihydropyridine receptorCaffeine-induced CaRyanodine receptor 1Receptor 1Muscle contractionInternal storesMuscle Ca2Muscle fibersSTAC3Luminal CaMyopathyTransverse tubule membranesTubule membranesCaffeine sensitivityHuman myopathiesCoupling apparatusHuman diseasesDynamic imagingCritical role