2020
Stac protein regulates release of neuropeptides
Hsu IU, Linsley JW, Zhang X, Varineau JE, Berkhoudt DA, Reid LE, Lum MC, Orzel AM, Leflein A, Xu H, Collins CA, Hume RI, Levitan ES, Kuwada JY. Stac protein regulates release of neuropeptides. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 29914-29924. PMID: 33168737, PMCID: PMC7703553, DOI: 10.1073/pnas.2009224117.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedBehavior Observation TechniquesBehavior, AnimalCalcium ChannelsDrosophila melanogasterDrosophila ProteinsFemaleIntracellular Signaling Peptides and ProteinsIntravital MicroscopyLarvaMaleModels, AnimalMotor NeuronsMuscle, SkeletalNeuromuscular JunctionNeuropeptidesOptical ImagingPatch-Clamp TechniquesPresynaptic TerminalsConceptsSTAC proteinsRelease of neuropeptidesVertebrate skeletal muscleSubset of neuronsMolecular regulationGenetic manipulationKey regulatorMotor neuronsCytosolic CaNumerous neural functionsSmall familyCentral nervous systemExcitation-contraction couplingGenesSkeletal muscleL-type CaProteinNeuropeptide releaseNervous systemNeural functionDrosophilaNeuropeptidesVertebratesNeuronsRegulator
2018
Dstac is required for normal circadian activity rhythms in Drosophila
Hsu IU, Linsley JW, Varineau JE, Shafer OT, Kuwada JY. Dstac is required for normal circadian activity rhythms in Drosophila. Chronobiology International 2018, 35: 1016-1026. PMID: 29621409, PMCID: PMC6103890, DOI: 10.1080/07420528.2018.1454937.Peer-Reviewed Original ResearchConceptsPigment Dispersing FactorS-LNSmall ventrolateral neuronsBrain of DrosophilaL-type voltage-gated CaCircadian activityNovel genesAdaptor proteinCircadian locomotionVoltage-gated CaActivity rhythmsDrosophilaDmca1DGenesVentrolateral neuronsCircadian activity rhythmsVertebratesSTAC3ProteinBindsCACHActivity
2015
Huntingtin-Associated Protein 1 Interacts with Breakpoint Cluster Region Protein to Regulate Neuronal Differentiation
Huang PT, Chen CH, Hsu IU, Salim S, Kao SH, Cheng CW, Lai CH, Lee CF, Lin YF. Huntingtin-Associated Protein 1 Interacts with Breakpoint Cluster Region Protein to Regulate Neuronal Differentiation. PLOS ONE 2015, 10: e0116372. PMID: 25671650, PMCID: PMC4324908, DOI: 10.1371/journal.pone.0116372.Peer-Reviewed Original ResearchConceptsBreakpoint cluster region proteinMicrotubule-dependent traffickingNeuronal differentiationRho GTPase regulatorsRegion proteinsProtein 1 interactsNeuro-2a cellsExtracellular signalsBrain-enriched proteinProteomic analysisGTPase regulatorDownstream effectorsPostnatal lethalityHAP1Neuronal cellsWild-type mouse brainProtein 1TraffickingNeurite outgrowthTropomyosin-related kinaseProteinKinaseNeurodegenerative diseasesDifferentiationMicrotubules