2024
Women with endometriosis in the United States: National Survey of Family Growth, 2011–2019
Al-Lami R, Taha S, Jalloul R, Taylor H. Women with endometriosis in the United States: National Survey of Family Growth, 2011–2019. Journal Of Endometriosis And Uterine Disorders 2024, 8: 100081. DOI: 10.1016/j.jeud.2024.100081.Peer-Reviewed Original ResearchNational Survey of Family GrowthAssociated with infertilityFamily GrowthRates of functional impairmentQuality of lifeNational surveyWeighted prevalencePrevalence of infertilityPain associated with endometriosisLongitudinal population-based studyAssociated with endometriosisPrevalence of endometriosisFunctional impairmentNationally representative samplePopulation-based studyDiminished quality of lifeLogistic regression analysisSample of womenCross-sectional studyCharacteristics of womenInfertile womenEndometriosisReproductive factorsU.S. womenAnalytic sampleTET3-overexpressing macrophages promote endometriosis
Lv H, Liu B, Dai Y, Li F, Bellone S, Zhou Y, Mamillapalli R, Zhao D, Venkatachalapathy M, Hu Y, Carmichael G, Li D, Taylor H, Huang Y. TET3-overexpressing macrophages promote endometriosis. Journal Of Clinical Investigation 2024, 134: e181839. PMID: 39141428, PMCID: PMC11527447, DOI: 10.1172/jci181839.Peer-Reviewed Original ResearchDisease-associated macrophagesTET3 overexpressionHuman endometriosis lesionsPathophysiology of endometriosisPro-inflammatory cytokine productionChronic inflammatory diseaseReproductive age womenEndometriosis lesionsE3 ubiquitin ligasePathogenic macrophagesCytokine productionEndometriosisInflammatory diseasesTET3 knockdownEndometriosis progressionPathogenic contributorsLet-7 miRNA expressionAge womenMacrophagesMouse macrophagesTherapeutic targetUbiquitin ligaseTET3MiceDiseaseIs There an Association Between Endometriosis, Early Menopause, and Cardiovascular Disease?
Younis J, Taylor H. Is There an Association Between Endometriosis, Early Menopause, and Cardiovascular Disease? The Journal Of Clinical Endocrinology & Metabolism 2024, 109: e1946-e1949. PMID: 39083665, DOI: 10.1210/clinem/dgae508.Peer-Reviewed Original ResearchEarly menopauseEndometriotic cystectomyNatural menopauseCardiovascular riskCardiovascular diseaseEndometriosis-associated pelvic painIncreased risk of cardiovascular diseaseLaparoscopically diagnosed endometriosisRisk of cardiovascular diseaseEarly natural menopauseLarge-scale cohort studyPelvic painOvarian reserveBilateral casesMenopause onsetMultiple surgeriesEndometriosisCohort studyHazard ratioIncreased riskMenopauseCystectomyRisk factorsEstimates of associationConfounding factorsMedical Management of Endometriosis in Adolescent and Young Adult Women: A Review of 91 Cases of Biopsy-Confirmed Endometriosis
Li H, Esencan E, Song Y, Taylor H, Cho Y, Vash-Margita A. Medical Management of Endometriosis in Adolescent and Young Adult Women: A Review of 91 Cases of Biopsy-Confirmed Endometriosis. Journal Of Obstetrics And Gynaecology Canada 2024, 46: 102562. PMID: 38759792, DOI: 10.1016/j.jogc.2024.102562.Peer-Reviewed Original ResearchCombined oral contraceptivesBiopsy-proven endometriosisLNG-IUDManagement of endometriosisOral progestinInitial treatmentRetrospective chart review of womenChart review of womenMedical management of endometriosisProgestin-only formulationsLevonorgestrel intrauterine deviceReview of womenRetrospective chart reviewYoung adult patientsTertiary hospital systemPelvic painIntrauterine deviceOral contraceptivesTreatment regimensYounger patientsAdult patientsHormonal managementEndometriosisTreatment planningCurrent treatmentVilaprisan for the treatment of symptomatic endometriosis: results from a terminated phase 2b randomized controlled trial
Taylor H, Dong L, Haikonen J, Oppelt P, Tamussino K, Wenzl R, Faustmann T, Groettrup-Wolfers E, Ren X, Seitz C. Vilaprisan for the treatment of symptomatic endometriosis: results from a terminated phase 2b randomized controlled trial. F&S Reports 2024, 5: 189-196. PMID: 38983729, PMCID: PMC11228778, DOI: 10.1016/j.xfre.2024.03.002.Peer-Reviewed Original ResearchPelvic painSymptomatic endometriosisTreatment of symptomatic endometriosisEndometriosis-associated pelvic painBaseline to month 3Use of pain medicationAverage pain scoreMonths of treatmentPhase 2b randomized controlled trialAssess treatment effectsOutcome measures Primary outcomesPlacebo recipientsRandomized controlled trialsPain scoresMonth 3Pain medicationIncreased painVilaprisanPlaceboPrimary outcomeEndometriosisToxicity findingsIntervention participantsClinical relevanceBleeding intensity
2023
CHARACTERIZATION OF PROGESTERONE RESISTANCE IN A PROSPECTIVE COHORT OF SURGICALLY CONFIRMED PATIENTS WITH OR WITHOUT ENDOMETRIOSIS
Singh B, Courtright L, Brennan J, Chen L, Wu H, Patzkowsky K, Wang K, Simpson K, Wang T, Shih I, Cope L, Schepisi L, Taylor H, Segars J. CHARACTERIZATION OF PROGESTERONE RESISTANCE IN A PROSPECTIVE COHORT OF SURGICALLY CONFIRMED PATIENTS WITH OR WITHOUT ENDOMETRIOSIS. Fertility And Sterility 2023, 120: e224. DOI: 10.1016/j.fertnstert.2023.08.639.Peer-Reviewed Original ResearchClinical applications of gonadotropin-releasing hormone analogues: a broad impact on reproductive medicine
Saleh F, Taylor H. Clinical applications of gonadotropin-releasing hormone analogues: a broad impact on reproductive medicine. F&S Reports 2023, 4: 83-87. PMID: 37223759, PMCID: PMC10201293, DOI: 10.1016/j.xfre.2023.01.008.Peer-Reviewed Original ResearchHormone analogueGonadotropin-releasing hormone analogueOral GnRH antagonistCommon gynecologic conditionOvarian hormone productionClinical applicationGnRH antagonistPituitary responseGnRH activityGnRH analoguesGynecologic conditionsTreatment optionsGonadal axisReproductive axisRapid onsetGynecologic practiceHormone productionReproductive medicineReproductive technologiesDiverse clinical applicationsGonadotropinEndometriosisFibroidsGnRHAntagonist
2022
Endometriosis-associated infertility: From pathophysiology to tailored treatment
Bonavina G, Taylor H. Endometriosis-associated infertility: From pathophysiology to tailored treatment. Frontiers In Endocrinology 2022, 13: 1020827. PMID: 36387918, PMCID: PMC9643365, DOI: 10.3389/fendo.2022.1020827.Peer-Reviewed Original ResearchConceptsEndometriosis-associated infertilityRole of surgeryCurrent treatment optionsNon-invasive diagnostic toolLevel of impairmentInfertile womenRelated infertilityEndometrial receptivitySystemic diseaseTreatment optionsClinical managementDysfunctional alterationsEndometriosisSystemic effectsClinical situationsInfertilityPelvic anatomyClinical settingEndometriosis subtypesPrecise diagnosisPatient phenotypesReproductive technologiesDiagnostic toolTreatmentPhenotype
2012
A polymorphism in a let‐7 microRNA binding site of KRAS in women with endometriosis
Grechukhina O, Petracco R, Popkhadze S, Massasa E, Paranjape T, Chan E, Flores I, Weidhaas JB, Taylor HS. A polymorphism in a let‐7 microRNA binding site of KRAS in women with endometriosis. EMBO Molecular Medicine 2012, 4: 206-217. PMID: 22307873, PMCID: PMC3376847, DOI: 10.1002/emmm.201100200.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsKRAS-variantCultured endometrial stromal cellsStromal cellsAbnormal endometrial growthDe novo endometriosisProgesterone receptor levelsRelatives of womenEndometrial xenograftsKRAS resultsLCS6 polymorphismEndometrial growthReproductive ageKRAS mutationsReceptor levelsMurine modelEndometriosisEndometriosis riskControl populationVariant allelesKRAS mRNAProtein expressionKRASWomenKRAS protein
2011
Novel Therapies Targeting Endometriosis
Taylor HS, Osteen KG, Bruner-Tran KL, Lockwood CJ, Krikun G, Sokalska A, Duleba AJ. Novel Therapies Targeting Endometriosis. Reproductive Sciences 2011, 18: 814-823. PMID: 21693775, PMCID: PMC4046304, DOI: 10.1177/1933719111410713.Peer-Reviewed Original ResearchConceptsNonhuman primate trialsAnti-inflammatory drugsProgesterone modulatorsEndometrial glandsPainful disordersNovel therapiesCommon causeSelective estrogenAntiangiogenic agentsWomen's qualityPotential therapyRodent modelsEndometriosisTherapyDiseaseStem cellsFurther testingPromising new developmentStatinsEstrogenInfertilityUterusStromaTrialsTreatment with Bazedoxifene, a Selective Estrogen Receptor Modulator, Causes Regression of Endometriosis in a Mouse Model
Kulak J, Fischer C, Komm B, Taylor HS. Treatment with Bazedoxifene, a Selective Estrogen Receptor Modulator, Causes Regression of Endometriosis in a Mouse Model. Endocrinology 2011, 152: 3226-3232. PMID: 21586552, PMCID: PMC3138238, DOI: 10.1210/en.2010-1010.Peer-Reviewed Original ResearchConceptsSelective estrogen receptor modulatorsRegression of endometriosisTreatment of endometriosisEstrogen receptor modulatorsReceptor modulatorsEstrogen-dependent disorderTissue-selective actionSignificant side effectsCD-1 miceEndometrial gene expressionCentral nervous systemEffective novel agentsExpression of PREndometrial stimulationGnRH agonistOvarian enlargementER expressionLIF mRNAExperimental endometriosisEstrogen antagonismER antagonistNovel agentsSERM bazedoxifeneEndometriosisMouse model
2008
Experimental Murine Endometriosis Induces DNA Methylation and Altered Gene Expression in Eutopic Endometrium1
Lee B, Du H, Taylor HS. Experimental Murine Endometriosis Induces DNA Methylation and Altered Gene Expression in Eutopic Endometrium1. Biology Of Reproduction 2008, 80: 79-85. PMID: 18799756, PMCID: PMC2804809, DOI: 10.1095/biolreprod.108.070391.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNA MethylationEndometriosisEndometriumFemaleGene Expression RegulationHomeobox A10 ProteinsHomeodomain ProteinsImmunohistochemistryInsulin-Like Growth Factor Binding Protein 1Integrin beta ChainsKruppel-Like Transcription FactorsMiceReceptors, ProgesteroneReverse Transcriptase Polymerase Chain ReactionRNA, MessengerConceptsEndometriosis groupEndometrial receptivityEutopic endometriumExperimental endometriosisAltered gene expressionInsulin-like growth factorInduction of endometriosisKruppel-like factor 9Expression of HOXA10Total progesterone receptorEndometrial gene expressionBeta3 mRNA expressionProtein-1 mRNAReal-time RT-PCRQuantitative real-time RT-PCRGene expressionMurine endometriosisNormal endometriumProgesterone receptorMethylation-specific PCREndometriosisEndometriumMRNA expressionEctopic locationsGrowth factor