Huey Cai
Research Scientist of Ophthalmology and Visual ScienceCards
About
Research
Publications
2026
Circulating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study
Zheng Y, Yang J, Gupta D, Herrington D, Yu B, Nguyen N, Pinto R, Tzoulaki I, Cai H, Cai Q, Lipworth L, Shu X, Zheng W, Yu D. Circulating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study. PLOS Medicine 2026, 23: e1004750. PMID: 41843497, PMCID: PMC12994840, DOI: 10.1371/journal.pmed.1004750.Peer-Reviewed Original ResearchConceptsIncident coronary heart diseaseBody mass indexCoronary heart diseaseFollow-up timeOdds ratioMulti-Ethnic StudyShanghai Women's Health StudyHeart diseaseShanghai Men's Health StudyMetabolic disease historyHealth StudyAssociated with incident coronary heart diseaseMicrobial metabolitesWomen's Health StudySouthern Community Cohort StudyPlasma metabolite profilesCoronary heart disease developmentMen's Health StudyRisk of coronary heart diseaseConditional logistic regressionHuman cardiometabolic healthMulti-Ethnic Study of AtherosclerosisCommunity Cohort StudyGut microbial metabolismCoronary heart disease diagnosisDynamics of the association between circulating levels of miRNA and pancreatic cancer risk through the years prior to pancreatic cancer diagnosis
Cai H, Setiawan V, Guo X, Wu J, Stolzenberg‐Solomon R, Gao Y, Berlin J, Ye F, Cai Q, Zheng W, Shu X. Dynamics of the association between circulating levels of miRNA and pancreatic cancer risk through the years prior to pancreatic cancer diagnosis. International Journal Of Cancer 2026 PMID: 41845595, DOI: 10.1002/ijc.70452.Peer-Reviewed Original ResearchPancreatic ductal adenocarcinomaCase-control differencesMiR-493-3pPancreatic ductal adenocarcinoma diagnosisAssociated with PDAC riskYears prior to cancer diagnosisCancer diagnosisPre-diagnostic plasma samplesPancreatic cancer riskEarly diagnosisConditional logistic regressionCancer-free controlsProspective cohort studyHigh-risk individualsMiR-493Levels of miRNAsBiology of pancreatic ductal adenocarcinomaEarly diagnosis of pancreatic ductal adenocarcinomaDiagnosis of pancreatic ductal adenocarcinomaPancreatic cancer diagnosisCancer riskPancreatic ductal adenocarcinoma casesMiR-155Risk surveillanceCohort studyEstrogen metabolism-related lifestyle score and risk of postmenopausal breast, endometrial, and ovarian cancers: findings from two large prospective cohort studies.
Yuan F, Shu X, Long J, Huang W, Lipworth L, Xu X, Khankari N, Watts E, Tao R, Cai H, Moore S, Zheng W. Estrogen metabolism-related lifestyle score and risk of postmenopausal breast, endometrial, and ovarian cancers: findings from two large prospective cohort studies. Cancer Prevention Research 2026, of1-of10. PMID: 41808586, DOI: 10.1158/1940-6207.capr-25-0382.Peer-Reviewed Original ResearchRisk of postmenopausal breastLifestyle scoreAssociated with lower riskRisk of breastPostmenopausal breastLifestyle patternsShanghai Women's Health StudyEstrogen metabolitesHazard ratioOvarian Screening TrialLower risk of breastWomen's Health StudyConfidence intervalsOvarian cancerEndometrial cancerParent estrogensEtiology of hormone-related cancersProspective cohort studyER-negative breast cancerEstrogen receptor (ER)-positiveLow riskCox proportional hazards modelsHormone-related cancersProportional hazards modelHealth Study
2025
Association of physical activity with gut microbiome among low-income black American adults in the Southern Community Cohort Study
Shi J, Nguyen S, Yu D, Wang L, Liu L, Cai H, Wu J, Long J, Cai Q, Shrubsole M, Zheng W, Shu X. Association of physical activity with gut microbiome among low-income black American adults in the Southern Community Cohort Study. Gut Microbes Reports 2025, 2: 2589861. PMID: 41909911, PMCID: PMC12940208, DOI: 10.1080/29933935.2025.2589861.Peer-Reviewed Original ResearchModerate-vigorous PASouthern Community Cohort StudyPhysical activityCommunity Cohort StudyGut microbiomeAmerican adultsBlack American adultsA-diversityAbundance of individual speciesMetabolic pathwaysAssociation of physical activityShotgun metagenomic sequencingCohort studyBray-Curtis dissimilarityMicrobial metabolic pathwaysGeneralized linear regression modelsMetagenomic sequencingXyloglucan degradationBacterial speciesMicrobial compositionPA dataIndividual speciesBacteroides speciesCohort enrollmentLinear regression modelsHigher lung cancer risk among female never-smokers than males in a large married couple study
Cai H, Shu X, Wu S, Gao Y, Lan Q, Rothman N, Zheng W, Yang G. Higher lung cancer risk among female never-smokers than males in a large married couple study. Lung Cancer 2025, 210: 108836. PMID: 41237664, DOI: 10.1016/j.lungcan.2025.108836.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosAge-standardized incidence rateLung cancer riskHazard ratioCancer riskIncidence rateHigher lung cancer riskAge-standardized ratesIncident lung cancerIntensity of cigarette smokingFemale never-smokersDual-smoker couplesEver smokingNever smokersRate ratiosCox regression modelsNever-smokersCohort studyMultivariable adjustmentCigarette smokingLung cancerSex differencesRegression modelsCohortSmokingAssessment of Adipokine and Inflammation Biomarkers with Cancer Risk among Chinese Men: A Prospective Cohort Study.
DeMoulin D, Cai H, Cai Q, Zheng W, Shu X. Assessment of Adipokine and Inflammation Biomarkers with Cancer Risk among Chinese Men: A Prospective Cohort Study. Cancer Epidemiology Biomarkers & Prevention 2025, 34: 2104-2116. PMID: 40900641, PMCID: PMC12477761, DOI: 10.1158/1055-9965.epi-25-0342.Peer-Reviewed Original ResearchAssociated with colorectal cancerAssociated with lung cancerCancer riskColorectal cancerShanghai Men's Health StudyChinese menAssociated with cancer riskCancer risk factorsConfidence intervalsC-reactive proteinMen's Health StudyProspective cohort studyHigh-risk individualsPlasminogen activator inhibitor type 1Monocyte chemoattractant protein-1Health StudyTargeted interventionsLung cancerCox regression modelsCohort studyHazard ratioInterleukin-8Obesity biomarkersRisk factorsInflammation biomarkersAssociations of prediagnostic serum liver enzyme levels with lung cancer risk in predominantly low-income African and European Americans
Xu S, Cai H, Wu J, Shi J, Courtney R, Yoon H, Shu X, Blot W, Zheng W, Cai Q. Associations of prediagnostic serum liver enzyme levels with lung cancer risk in predominantly low-income African and European Americans. Carcinogenesis 2025, 46: bgaf052. PMID: 40879454, PMCID: PMC12504949, DOI: 10.1093/carcin/bgaf052.Peer-Reviewed Original ResearchLC riskOdds ratioSouthern Community Cohort StudyIncident LC casesAfrican AmericansConfidence intervalsCommunity Cohort StudyLung cancer riskSerum ALT levelsPotential effect modifiersConditional logistic regressionLiver enzyme levelsEuropean AmericansMatched ControlsALT levelsCancer riskInverse associationLow-incomeEffect modifiersStudy participantsBaseline serum alanine aminotransferaseBaseline serum alkaline phosphataseLowest tertileMedian follow-up timeCohort studySex‐Specific Aging Patterns of Gut Microbiota in Urban Chinese Adults: Guild‐Based Analysis and Implications for Healthy Aging
Fu J, Xu W, Yu D, Jiang Y, Wang L, Cai H, Xia Q, Shu X, Zheng W. Sex‐Specific Aging Patterns of Gut Microbiota in Urban Chinese Adults: Guild‐Based Analysis and Implications for Healthy Aging. Aging Cell 2025, 24: e70192. PMID: 40757475, PMCID: PMC12507401, DOI: 10.1111/acel.70192.Peer-Reviewed Original ResearchPatterns of gut microbiotaGut microbiotaBray-CurtisRRNA gene sequencesEcological indicatorsGroup of bacteriaMicrobial agingBray-Curtis distanceGene sequencesShanghai MePielou's evennessHealthy lifestyleMicrobial guildsChinese adultsChao1 indexHigher risk of type 2 diabetesHealthy lifestyle behaviorsMicrobiotaRisk of type 2 diabetesWomen's Health StudyUrban Chinese adultsCoherent groupsGuildsHigh riskLifestyle behaviorsAlcohol intake and pancreatic cancer risk: An analysis from 30 prospective studies across Asia, Australia, Europe, and North America
Naudin S, Wang M, Dimou N, Ebrahimi E, Genkinger J, Adami H, Albanes D, Babic A, Barnett M, Bogumil D, Cai H, Chen C, Eliassen A, Freudenheim J, Gierach G, Giovannucci E, Gunter M, Håkansson N, Hirabayashi M, Hou T, Huang B, Huang W, Jayasekara H, Jones M, Katzke V, Koh W, Lacey J, Lagerros Y, Larsson S, Liao L, Lo K, Loftfield E, MacInnis R, Männistö S, McCullough M, Miller A, Milne R, Moore S, Mucci L, Neuhouser M, Patel A, Platz E, Prizment A, Robien K, Rohan T, Sacerdote C, Sandin S, Sawada N, Schoemaker M, Shu X, Sinha R, Snetselaar L, Stampfer M, Stolzenberg-Solomon R, Thomson C, Tjønneland A, Um C, van den Brandt P, Visvanathan K, Wang S, Wang R, Weiderpass E, Weinstein S, White E, Willett W, Woslk A, Wolpin B, Yaun S, Yuan C, Yuan J, Zheng W, Brennan P, Smith-Warner S, Ferrari P. Alcohol intake and pancreatic cancer risk: An analysis from 30 prospective studies across Asia, Australia, Europe, and North America. PLOS Medicine 2025, 22: e1004590. PMID: 40392909, PMCID: PMC12091891, DOI: 10.1371/journal.pmed.1004590.Peer-Reviewed Original ResearchConceptsPancreatic cancer riskAssociated with pancreatic cancer riskCancer riskAlcohol intakeSmoking statusSex-stratified Cox proportional hazards modelsIncident pancreatic cancer casesCategories of alcohol intakeLarge-scale pooled analysisHazard ratioCancer hazard ratioConfidence intervalsBaseline alcohol intakePancreatic cancer casesCox proportional hazards modelsBody mass indexIndividual-level dataAlcoholic beveragesEvidence of heterogeneityPhysical activityInternational expert panelProportional hazards modelProspective studyNever smokersCancer casesAssociation Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium
Lee S, Ahn C, Abe S, Rahman S, Islam R, Saito E, An S, Sawada N, Shu X, Koh W, Cai H, Hozawa A, Kanemura S, Nagata C, You S, Kang D, Kanehara R, Gao Y, Yuan J, Wen W, Sugawara Y, Wada K, Chen C, Yoo K, Ahsan H, Chia K, Shin A, Kim J, Lee J, Matsuo K, Rothman N, Qiao Y, Zheng W, Boffetta P, Inoue M, Park S. Association Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium. Journal Of Epidemiology 2025, 35: 321-329. PMID: 40368779, PMCID: PMC12162181, DOI: 10.2188/jea.je20240362.Peer-Reviewed Original ResearchAsia Cohort ConsortiumCardiovascular disease mortalityAll-CauseHazard ratioCardiometabolic multimorbidityCohort ConsortiumPremature mortalityCardiovascular diseaseAge- and sex-adjusted hazard ratioSex-adjusted hazard ratioCardiometabolic diseasesRisk of premature mortalityCohort studyConfidence intervalsIndividual cardiometabolic diseasesProspective cohort studyBody mass indexHigh-risk conditionsPersonalized management strategiesAsian cohort studiesMultimorbiditySmoking statusIschemic heart diseaseMortality riskCox hazard regression
Get In Touch
Contacts
Email