Mechanistic Investigation of Human DPP9 Deficiency
Xiao T, Brewer J, Zhou L, Han A, Takabe Y, Carlino M, Blackburn H, Flavell R. Mechanistic Investigation of Human DPP9 Deficiency. Blood 2024, 144: 5699-5699. DOI: 10.1182/blood-2024-211123.Peer-Reviewed Original ResearchHuman HSPCsDevelopment of human immune systemHuman NLRP1Loss of hematopoietic cellsHumanized mouse modelHuman hematopoietic stemStem cells in vivoSensors of infectionLaboratory mouse strainsCells in vivoHuman immune systemMouse genomeHematopoietic stemHuman hematopoiesisHematopoietic cellsCellular stressNegative regulatorPancytopeniaProgenitor cellsMouse strainsRegulatory pathwaysMouse modelHSPCsImmune systemDeletion