2022
Effect of an Active vs Expectant Management Strategy on Successful Resolution of Pregnancy Among Patients With a Persisting Pregnancy of Unknown Location: The ACT or NOT Randomized Clinical Trial
Barnhart K, Hansen K, Stephenson M, Usadi R, Steiner A, Cedars M, Jungheim E, Hoeger K, Krawetz S, Mills B, Alston M, Coutifaris C, Senapati S, Sonalkar S, Diamond M, Wild R, Rosen M, Sammel M, Santoro N, Eisenberg E, Huang H, Zhang H. Effect of an Active vs Expectant Management Strategy on Successful Resolution of Pregnancy Among Patients With a Persisting Pregnancy of Unknown Location: The ACT or NOT Randomized Clinical Trial. Obstetrical & Gynecological Survey 2022, 77: 24-26. DOI: 10.1097/01.ogx.0000805156.32421.70.Peer-Reviewed Original Research
2016
Testing Violations of the Exponential Assumption in Cancer Clinical Trials with Survival Endpoints
Han G, Schell MJ, Zhang H, Zelterman D, Pusztai L, Adelson K, Hatzis C. Testing Violations of the Exponential Assumption in Cancer Clinical Trials with Survival Endpoints. Biometrics 2016, 73: 687-695. PMID: 27669414, PMCID: PMC6093291, DOI: 10.1111/biom.12590.Peer-Reviewed Original ResearchAcupuncture and clomiphene for infertility in the polycystic ovary syndrome: a multicentre rondomized controlled trial
Wu X, Stener-Victorin E, Liu J, Wu T, Ng E, Legro R, Zhang H. Acupuncture and clomiphene for infertility in the polycystic ovary syndrome: a multicentre rondomized controlled trial. Fertility And Sterility 2016, 106: e375. DOI: 10.1016/j.fertnstert.2016.08.002.Peer-Reviewed Original Research
2015
Recruitment strategies in two reproductive medicine network infertility trials
Usadi RS, Diamond MP, Legro RS, Schlaff WD, Hansen KR, Casson P, Christman G, Bates G, Baker V, Seungdamrong A, Rosen MP, Lucidi S, Thomas T, Huang H, Santoro N, Eisenberg E, Zhang H, Alvero R, Network F. Recruitment strategies in two reproductive medicine network infertility trials. Contemporary Clinical Trials 2015, 45: 196-200. PMID: 26386293, PMCID: PMC4766588, DOI: 10.1016/j.cct.2015.09.010.Peer-Reviewed Original ResearchConceptsPPCOS IIMultiple Intrauterine GestationsPolycystic ovary syndromeRecruitment strategiesSuccessful recruitment strategiesInfertility trialsOvarian stimulationIntrauterine gestationOvary syndromeWhite patientsBlack patientsDifferent recruitment strategiesPhysician referralClinical trialsInfertile couplesTrial completionClinical sitesTrialsRecruitment methodsPatientsSimilar ratesPhysiciansWomenParticipantsSuccessful strategyMale obesity is an independent risk factor for treatment failure among couples with unexplained infertility in the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial
Polotsky A, Allshouse A, Krawetz S, Santoro N, Eisenberg E, Zhang H, Diamond M. Male obesity is an independent risk factor for treatment failure among couples with unexplained infertility in the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial. Fertility And Sterility 2015, 104: e78. DOI: 10.1016/j.fertnstert.2015.07.238.Peer-Reviewed Original ResearchUtility of sonohysterography for tubal patency assessment in the pregnancy in polycystic ovary syndrome II trial
Christianson M, Legro R, Jin S, Eisenberg E, Diamond M, Hansen K, Vitek W, Styer A, Casson P, Coutifaris C, Christman G, Alvero R, Puscheck E, Christy A, Zhang H, Polotsky A, Santoro N. Utility of sonohysterography for tubal patency assessment in the pregnancy in polycystic ovary syndrome II trial. Fertility And Sterility 2015, 104: e98-e99. DOI: 10.1016/j.fertnstert.2015.07.304.Peer-Reviewed Original Research
2013
Acupuncture and Clomiphene Citrate for Live Birth in Polycystic Ovary Syndrome: Study Design of a Randomized Controlled Trial
Kuang H, Li Y, Wu X, Hou L, Wu T, Liu J, Ng EH, Stener-Victorin E, Legro RS, Zhang H. Acupuncture and Clomiphene Citrate for Live Birth in Polycystic Ovary Syndrome: Study Design of a Randomized Controlled Trial. Evidence-based Complementary And Alternative Medicine 2013, 2013: 527303. PMID: 24023577, PMCID: PMC3762180, DOI: 10.1155/2013/527303.Peer-Reviewed Original ResearchPolycystic ovary syndromeControl acupuncturePCOS womenTrue acupunctureOvary syndromeLive birthsEfficacy of acupunctureLive birth rateFirst-line medicineSafety monitoring boardClomiphene citrateOngoing multicenterAdjuvant treatmentOvulation inductionControlled TrialsTreatment armsAlternative therapiesMonitoring boardAcupunctureFertility treatmentCentral mechanismsStudy designTrialsBirth rateWomen
2011
Recruitment challenges of a multicenter randomized controlled varicocelectomy trial
Trussell JC, Christman GM, Ohl DA, Legro RS, Krawetz SA, Snyder PJ, Patrizio P, Polotsky AJ, Diamond MP, Casson PR, Coutifaris C, Barnhart K, Brzyski RG, Schlaff WD, Meacham R, Shin D, Thomas T, Zhang M, Santoro N, Eisenberg E, Zhang H, Network R. Recruitment challenges of a multicenter randomized controlled varicocelectomy trial. Fertility And Sterility 2011, 96: 1299-1305. PMID: 22130101, PMCID: PMC3243664, DOI: 10.1016/j.fertnstert.2011.10.025.Peer-Reviewed Original ResearchConceptsReproductive Medicine NetworkPlacebo armInfertility evaluationIntrauterine inseminationMedicine NetworkSuboptimal recruitmentClinical trial enrollmentMale infertility studiesAscertain reasonsIUI cyclesInfertile womenTrial enrollmentSurgical interventionPatient educationMAIN OUTCOMEStudy recruitmentInfertile menMale infertilityStudy participantsInfertility studiesMale partnersRecruitment challengesTrialsInadequate recruitmentFertility interventionsIncreasing burden of institutional review in multicenter clinical trials of infertility: the Reproductive Medicine Network experience with the Pregnancy in Polycystic Ovary Syndrome (PPCOS) I and II studies
Schlaff WD, Zhang H, Diamond MP, Coutifaris C, Casson PR, Brzyski RG, Christman GM, Barnhart KT, Trussell JC, Krawetz SA, Snyder PJ, Ohl D, Santoro N, Eisenberg E, Huang H, Legro RS, Network R. Increasing burden of institutional review in multicenter clinical trials of infertility: the Reproductive Medicine Network experience with the Pregnancy in Polycystic Ovary Syndrome (PPCOS) I and II studies. Fertility And Sterility 2011, 96: 15-18. PMID: 21645894, PMCID: PMC3151556, DOI: 10.1016/j.fertnstert.2011.05.069.Peer-Reviewed Original ResearchConceptsPolycystic Ovary Syndrome IReproductive Medicine NetworkMulticenter clinical trialMulticenter trialClinical trialsSubstantial burdenInstitutional reviewClinical investigatorsMedicine NetworkSignificant increaseBurdenTrialsInstitutional review board requirementsObjective dataIRB submissionPregnancyInfertilityHuman research participantsYearsSignificant variability
2006
Longitudinal Effects of Coping on Outcome in a Randomized Controlled Trial of a Group Intervention for HIV-Positive Adults with AIDS-Related Bereavement
Hansen NB, Tarakeshwar N, Ghebremichael M, Zhang H, Kochman A, Sikkema KJ. Longitudinal Effects of Coping on Outcome in a Randomized Controlled Trial of a Group Intervention for HIV-Positive Adults with AIDS-Related Bereavement. Death Studies 2006, 30: 609-636. PMID: 16865824, DOI: 10.1080/07481180600776002.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdaptation, PsychologicalAdultBereavementEthnicityFemaleGriefHIV SeropositivityHumansLongitudinal StudiesMaleNew YorkPsychotherapy, GroupQuality of LifeRandomized Controlled Trials as TopicSexual BehaviorTime FactorsTreatment OutcomeUnited StatesWisconsinConceptsPsychiatric distressHIV-positive adultsHIV-positive participantsOutcome one yearCoping strategiesQuality of lifeMeasures of griefLongitudinal effectsControlled TrialsAvoidant coping strategiesIntervention participantsLongitudinal courseOne-yearGroup interventionOutcome variablesAvoidant copingGreater reductionInterventionAIDSDistressTrialsStudy conditionsCopingGriefParticipants