2015
Genes and environment in neonatal intraventricular hemorrhage
Ment LR, Ådén U, Bauer CR, Bada HS, Carlo WA, Kaiser JR, Lin A, Cotten CM, Murray J, Page G, Hallman M, Lifton RP, Zhang H, Network O. Genes and environment in neonatal intraventricular hemorrhage. Seminars In Perinatology 2015, 39: 592-603. PMID: 26516117, PMCID: PMC4668116, DOI: 10.1053/j.semperi.2015.09.006.Peer-Reviewed Original ResearchConceptsIntraventricular hemorrhagePreterm neonatesLow birth weight preterm neonatesSevere intraventricular hemorrhageWeight preterm neonatesNeonatal intraventricular hemorrhageCerebral blood flowBlood flowVascular pathwaysCandidate gene studiesGenetic factorsComplex disorderHemorrhageNeonatesAngiogenesisGene studiesGenome-wide association studiesCluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms
Esplin MS, Manuck TA, Varner MW, Christensen B, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J. Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms. American Journal Of Obstetrics And Gynecology 2015, 213: 429.e1-429.e9. PMID: 26070700, PMCID: PMC4556543, DOI: 10.1016/j.ajog.2015.06.011.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthDecidual hemorrhagePlacental dysfunctionProspective case-control multicenter studyCase-control multicenter studyPremature membrane ruptureGroup of womenCommon biologic pathwaysMaternal comorbiditiesPreterm singletonsPreterm birthWeeks' gestationMulticenter studyMaternal stressSecondary analysisBiologic pathwaysFamilial factorsGenetic factorsWomenPhenotypic profileGestationInfectionMembrane ruptureCommon mechanismPhenotypeGenetic susceptibility to diffuse large B‐cell lymphoma in a pooled study of three Eastern Asian populations
Bassig BA, Cerhan JR, Au WY, Kim HN, Sangrajrang S, Hu W, Tse J, Berndt S, Zheng T, Zhang H, Pornsopone P, Lee JJ, Kim HJ, Skibola CF, Vijai J, Burdette L, Yeager M, Brennan P, Shin MH, Liang R, Chanock S, Lan Q, Rothman N. Genetic susceptibility to diffuse large B‐cell lymphoma in a pooled study of three Eastern Asian populations. European Journal Of Haematology 2015, 95: 442-448. PMID: 25611436, DOI: 10.1111/ejh.12513.Peer-Reviewed Original ResearchConceptsLarge B-cell lymphomaNon-Hodgkin lymphomaB-cell lymphomaDLBCL riskSimilar genetic risk factorsCommon NHL subtypesEuropean ancestryRisk of DLBCLGenetic risk factorsGenome-wide association studiesPooled studiesAggressive subtypeRisk factorsNHL subtypesStudy populationSignificant associationDLBCL casesGenetic susceptibilityGenome-wide significanceLymphomaAsian populationsPooled seriesDLBCLGenetic factorsEastern Asian populations
2010
The Impact of Environmental and Genetic Factors on Neonatal Late-Onset Sepsis
Bizzarro MJ, Jiang Y, Hussain N, Gruen JR, Bhandari V, Zhang H. The Impact of Environmental and Genetic Factors on Neonatal Late-Onset Sepsis. The Journal Of Pediatrics 2010, 158: 234-238.e1. PMID: 20850766, PMCID: PMC3008342, DOI: 10.1016/j.jpeds.2010.07.060.Peer-Reviewed Original ResearchMeSH KeywordsAge of OnsetBirth WeightBlood-Borne PathogensCohort StudiesConfidence IntervalsCross InfectionEnvironmental ExposureFemaleGenetic Predisposition to DiseaseHospital MortalityHumansInfant, NewbornIntensive Care Units, NeonatalLogistic ModelsMalePrognosisRetrospective StudiesSepsisSurvival RateTime FactorsTwinsTwins, DizygoticTwins, MonozygoticConceptsLate-onset sepsisNewborn intensive care unitIntensive care unitCare unitBirth weightIntensive care unit populationNeonatal late-onset sepsisRetrospective cohort analysisTotal parenteral nutritionRespiratory distress syndromeGenetic factorsLogistic regression analysisMixed-effects logistic regressionNongenetic factorsMixed-effects logistic regression analysisSignificant genetic susceptibilityDistress syndromeParenteral nutritionGestational ageCohort analysisSepsisUnit populationConcordance rateGenetic susceptibilityLogistic regression
2009
The familial aggregation of cannabis use disorders
Merikangas KR, Li JJ, Stipelman B, Yu K, Fucito L, Swendsen J, Zhang H. The familial aggregation of cannabis use disorders. Addiction 2009, 104: 622-629. PMID: 19335660, PMCID: PMC2794246, DOI: 10.1111/j.1360-0443.2008.02468.x.Peer-Reviewed Original ResearchConceptsSpouses of probandsFirst-degree relativesCannabis use disorderLife-time historyUse disordersAnxiety disordersAlcohol abuse/dependenceFamilial aggregationAbuse/dependenceFirst-degree adult relativesComorbid moodElevated riskFamily-based approachPsychiatric clinicAffective disordersAlcohol dependencePsychiatric conditionsFamily study methodDrug abuseFamilial factorsDisordersAdult relativesCannabisFamilial transmissionGenetic factorsGenetic Contribution to Patent Ductus Arteriosus in the Premature Newborn
Bhandari V, Zhou G, Bizzarro MJ, Buhimschi C, Hussain N, Gruen JR, Zhang H. Genetic Contribution to Patent Ductus Arteriosus in the Premature Newborn. Pediatrics 2009, 123: 669-673. PMID: 19171636, PMCID: PMC3161726, DOI: 10.1542/peds.2008-1117.Peer-Reviewed Original ResearchConceptsPatent ductus arteriosusDuctus arteriosusRespiratory distress syndromeGestational ageDistress syndromePostmenstrual agePremature newbornsGenetic factorsPreterm patent ductus arteriosusCommon congenital heart diseaseWeeks postmenstrual ageWeeks gestational ageCongenital heart diseaseMixed-effects logistic regressionTwin pairsAntenatal steroidsBronchopulmonary dysplasiaPreterm newbornsSignificant morbidityRetrospective studyOxygen supplementationHeart diseaseMonozygotic twin pairsPremature twinsArteriosus
1998
Familial Transmission of Substance Use Disorders
Merikangas KR, Stolar M, Stevens DE, Goulet J, Preisig MA, Fenton B, Zhang H, O'Malley SS, Rounsaville BJ. Familial Transmission of Substance Use Disorders. JAMA Psychiatry 1998, 55: 973-979. PMID: 9819065, DOI: 10.1001/archpsyc.55.11.973.Peer-Reviewed Original ResearchConceptsSubstance use disordersAdult first-degree relativesFirst-degree relativesDrug disordersRisk factorsUse disordersPredominant drugFamilial aggregationPotent risk factorRelatives of probandsAntisocial personality disorderFamily history interviewSubstance disordersFamily historyControl probandsDiagnostic InterviewOpioidsPersonality disorderDisordersFamilial transmissionGenetic factorsProbandsCocaineDrugsCannabis
1997
Strategies to Identify Genes for Complex Diseases
Zhang H, Zhao H, Merikangas K. Strategies to Identify Genes for Complex Diseases. Annals Of Medicine 1997, 29: 493-498. PMID: 9562515, DOI: 10.3109/07853899709007473.Peer-Reviewed Original ResearchConceptsComplex diseasesNumerous human diseasesDisease-susceptible genesComplex human disordersHuman genomeGenetic basisHuman disordersHuman diseasesMolecular biologyGenesGenetic epidemiological studiesGenetic factorsComplex patternsDisease pathophysiologyGenomeBiologyTraitsInheritanceMultiple sclerosisBreast cancerEpidemiological studies